ChemicalBook > CAS DataBase List > DGAT-3
DGAT-3
- Product Name
- DGAT-3
- CAS No.
- 701232-20-4
- Chemical Name
- DGAT-3
- Synonyms
- DGAT-3;CS-120;T-863;T 863;trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid;trans-Cyclohexaneacetic-acid,-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl];trans-2-(4-(4-(4-aMino-7,7-diMethyl-7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid;Mino-7,7-diMethyl-2-((1r,4r)-4-(4-(4-a7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid;Cyclohexaneacetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans-;2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid;Diglyceride acyltransferase,inhibit,acyl-CoA:cholesterol acyltransferase,T 863,T-863,T863,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,Diacylglycerol acyltransferase
- CBNumber
- CB31872285
- Molecular Formula
- C22H26N4O3
- Formula Weight
- 394.47
- MOL File
- 701232-20-4.mol
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DGAT-3 Property
- Boiling point:
- 616.6±55.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL (clear solution)
- pka
- 4.72±0.10(Predicted)
- form
- powder
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0539
- Product name
- T863
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $142
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0539
- Product name
- T863
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $334.2
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 25807
- Product name
- T-863
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 25807
- Product name
- T-863
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $129
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 25807
- Product name
- T-863
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $236
- Updated
- 2024/03/01
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DGAT-3 Chemical Properties,Usage,Production
Uses
T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:
- to provide the opportunity to precisely control the DGAT inhibition
- to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
- to specifically block neutral?lipid synthesis?and lipid droplet formation in HT-1080 cells
- to block lipid droplet (LD) formation
Biological Activity
diacylglycerol acyltransferase (dgat1) inhibitor
Biochem/physiol Actions
T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.
DGAT-3 Preparation Products And Raw materials
Raw materials
Preparation Products
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