Endoxifen

Product Name: Endoxifen
CAS No.: 112093-28-4
Chemical Name: Endoxifen
Synonyms: Avacopan;Endoxifen;Endoxifen(Z);(Z)-Endoxifen;Endoxifen (Z-isomer);salt CAS1032008-74-4;Tamoxifen Impurity 15;Endoxifen HCl Endoxifen Z-isomer;(Z)-4-Hydroxy-N-desmethyl Tamoxifen;Endoxifen (Z-isomer), 10 mM in DMSO
CBNumber: CB31872472
Molecular Formula: C25H27NO2
Formula Weight: 373.49
MOL File: 112093-28-4.mol

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Endoxifen Property

Melting point:: 127-129°C
Boiling point:: 519.3±50.0 °C(Predicted)
Density: 1.099±0.06 g/cm3(Predicted)
storage temp.: Amber Vial, -86°C Freezer, Under Inert Atmosphere
solubility: DMSO : 50 mg/mL (133.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 10.36±0.15(Predicted)
color: White to off-white
Stability:: Light Sensitive, Temperature Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Tocris

Product number: 3705
Product name: Endoxifen
Purity: ≥98%(HPLC)
Packaging: 10
Price: $221
Updated: 2021/12/16

Tocris

Product number: 3705
Product name: Endoxifen
Purity: ≥98%(HPLC)
Packaging: 50
Price: $909
Updated: 2021/12/16

Usbiological

Product number: 255247
Product name: Endoxifen
Packaging: 10mg
Price: $480
Updated: 2021/12/16

TRC

Product number: H938500
Product name: (Z)-4-Hydroxy-N-desmethylTamoxifen(containsupto10%Eisomer)
Packaging: 0.5mg
Price: $180
Updated: 2021/12/16

ApexBio Technology

Product number: B7481
Product name: Endoxifen
Packaging: 10mg
Price: $75
Updated: 2021/12/16

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Endoxifen Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pink Solid

Uses

A novel active metabolite of the anti-cancer drug Tamoxifen. It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast ca

Uses

A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.

Definition

ChEBI: 4-Hydroxy-N-desmethyltamoxifen is a stilbenoid.

Biological Activity

(Z)-Endoxifen (endoxifen) is an active tamoxifen metabolite generated via actions of cytochrome P450 (CYP) enzymes CYP3A4/5 and CYP2D6. Endoxifen is more potent than tamoxifen as a selective estrogen receptor modulator (SERM) both in vitro and in vivo with good pharmacokinetics and oral availability (∼80% MCF-7 tumor growth inhibition with 4-8 mg/kg/day endoxifen or 20 mg/kg/day tamoxifen in mice via p.o.). Endoxifen also exhibits 4-fold higher PKC inhibitory potency than tamoxifen and can overcome tamoxifen resistance due to cytochrome CYP2D6 polymorphism.

Endoxifen Preparation Products And Raw materials

Raw materials

Preparation Products

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Endoxifen Suppliers

Canada 1 China 84 India 3 United Kingdom 3 United States 12 Global 103

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

United States Biological

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Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

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View Lastest Price from Endoxifen manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Endoxifen 112093-28-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000KG
Release date: 2024-07-16

Career Henan Chemical Co

Product: Endoxifen 112093-28-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 90%-99.9%
Supply Ability: 10kg
Release date: 2019-07-04

112093-28-4, EndoxifenRelated Search:

Endoxifen HCl Tamoxifen Impurity 3 4-Benzyloxy β-Hydroxy TaMoxifen TaMoxifen DiMer 1-(4-(2-Dimethylamino)-2-ethoxyphenyl butanone N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture) 4Hydroxy Tamoxifen Tamoxifen EP Impurity D (E)-4-Alloxycarboxyl Tamoxifen desdimethyltamoxifen TAMOXIFEN-N-OXIDE Droloxifene (E)-4-Acetoxy Tamoxifen N-Desmethyl Tamoxifen Methanethiosulfonate 2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine alpha-[4-[2-(dimethylamino)ethoxy]phenyl]-beta-ethyl-alpha-phenylphenethyl alcohol (E)-4-Hydroxy-N-desmethyl Tamoxifen 4-HYDROXYTAMOXIFEN

(Z)-4-Hydroxy-N-desmethyl Tamoxifen

4-[(1Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol

Endoxifen

Phenol, 4-[(1Z)-1-[4-[2-(MethylaMino)ethoxy]phenyl]-2-phenyl-1-butenyl]-

(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer) see D292043

(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)

(Z)-4-Hydroxy-N-DesMethyl TaMoxifen (Endoxifen)

(Z)-Endoxifen

Endoxifen (Z-isomer)

Avacopan

4-[(1Z)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol

(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains 3% E isomer)

Endoxifen(Z)

salt CAS1032008-74-4

(Z)-4-Hydroxy-N-desmethyl Tamoxifen (mixture of isomers)

4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

(E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol

(Z)-4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

Endoxifen Z-isomer (contains 3% E isomer))

Phenol, 4-[(1Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-

Tamoxifen Citrate Impurity 17((Z)-4-Hydroxy-N-Desmethyl Tamoxifen)

Endoxifen HCl Endoxifen Z-isomer

Tamoxifen Impurity 15

Potassium Channel,Endoxifen (Z-isomer),Endoxifen (Zisomer),Endoxifen (Z isomer),Inhibitor,KcsA,inhibit,Estrogen Receptor/ERR

Endoxifen (Z-isomer), 10 mM in DMSO

112093-28-4

Inhibitors

Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

Aromatics

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals