4Hydroxy Tamoxifen
- Product Name
- 4Hydroxy Tamoxifen
- CAS No.
- 82413-23-8
- Chemical Name
- 4Hydroxy Tamoxifen
- Synonyms
- 4’-hydroxy Tamoxifen;Tamoxifen Citrate Impurity 18;4'-Hydroxy TaMoxifen (contains up to 10% E isoMer);Tamoxifen Citrate Impurity 13 (4'-Hydroxytamoxifen);4-[(1Z)-1-[[4-[2-(Dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]phenol;Phenol, 4-[(1Z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-
- CBNumber
- CB41175806
- Molecular Formula
- C26H29NO2
- Formula Weight
- 387.51
- MOL File
- 82413-23-8.mol
4Hydroxy Tamoxifen Property
- Melting point:
- 150-153°C
- Boiling point:
- 514.4±50.0 °C(Predicted)
- Density
- 1.092±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform (Slightly), Dichloromethane, Methanol (Slightly)
- form
- Solid
- pka
- 10.32±0.15(Predicted)
- color
- White to Off-White
- Stability:
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- 19519
- Product name
- 4’-hydroxy Tamoxifen
- Purity
- ≥98% (may contain up to 10% of the (E) isomer)
- Packaging
- 1mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 19519
- Product name
- 4’-hydroxy Tamoxifen
- Purity
- ≥98% (may contain up to 10% of the (E) isomer)
- Packaging
- 5mg
- Price
- $513
- Updated
- 2024/03/01
- Product number
- H954730
- Product name
- 4’-HydroxyTamoxifen(containsupto10%Eisomer)
- Packaging
- 25mg
- Price
- $1695
- Updated
- 2021/12/16
- Product number
- C4624
- Product name
- 4’-hydroxyTamoxifen
- Packaging
- 1mg
- Price
- $187
- Updated
- 2021/12/16
- Product number
- C4624
- Product name
- 4’-hydroxyTamoxifen
- Packaging
- 5mg
- Price
- $584
- Updated
- 2021/12/16
4Hydroxy Tamoxifen Chemical Properties,Usage,Production
Description
4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen , a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity. With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. At 10-100 μM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines.
Chemical Properties
White Solid
Uses
A metabolite of Tamoxifen (T006000).
References
[1] ROLAND L?SER . In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen[J]. European Journal of Cancer and Clinical Oncology, 1985, 21 8: Pages 985-990. DOI: 10.1016/0277-5379(85)90119-1
[2] H KIM CREWE. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4’-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.[J]. Drug Metabolism and Disposition, 2002, 32 1: 869-874. DOI: 10.1124/dmd.30.8.869
[3] H SEEGER. Inhibition of human breast cancer cell proliferation with estradiol metabolites is as effective as with tamoxifen.[J]. Hormone and Metabolic Research, 2004, 36 5: 277-280. DOI: 10.1055/s-2004-814480
[4] MARIA E CUEVAS Tracey E L. In vitro cytotoxicity of 4’-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B.[J]. Oncology reports, 2015, 33 1: 464-470. DOI: 10.3892/or.2014.3565
[5] GIORGIA URBINATI. Therapeutic potential of new 4-hydroxy-tamoxifen-loaded pH-gradient liposomes in a multiple myeloma experimental model.[J]. Pharmaceutical Research, 2010, 27 2: 327-339. DOI: 10.1007/s11095-009-0023-z
4Hydroxy Tamoxifen Preparation Products And Raw materials
Raw materials
Preparation Products
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