ChemicalBook > CAS DataBase List > N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)

N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)

Product Name
N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
CAS No.
110025-28-0
Chemical Name
N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
Synonyms
CS-2602;4OHNDtam;E/Z Endoxifen;Endoxifen (Z/E=3:2);Endoxifen(EE/Z=1:1);Endoxifen（E/Z=1: 1）;4-Hydroxy Endoxifen;(E /Z) Endoxifen HCl;Tamoxifen Impurity 16;Endoxifen, 10 mM in DMSO
CBNumber
CB61176584
Molecular Formula
C25H27NO2
Formula Weight
373.49
MOL File
110025-28-0.mol
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N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) Property

Melting point:
63-72°C
Boiling point:
519.3±50.0 °C(Predicted)
Density 
1.099±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform, Dichloromethane, DMSO, Methanol
form 
Solid
pka
9.38±0.15(Predicted)
color 
Light Brown to Light Purple
InChI
InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3
InChIKey
MHJBZVSGOZTKRH-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(C(C2=CC=C(OCCNC)C=C2)=C(C2=CC=CC=C2)CC)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21502
Product name
(E/Z)-Endoxifen
Purity
≥98% (mixture of isomers)
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
21502
Product name
(E/Z)-Endoxifen
Purity
≥98% (mixture of isomers)
Packaging
5mg
Price
$177
Updated
2024/03/01
Cayman Chemical
Product number
21502
Product name
(E/Z)-Endoxifen
Purity
≥98% (mixture of isomers)
Packaging
10mg
Price
$330
Updated
2024/03/01
Cayman Chemical
Product number
21502
Product name
(E/Z)-Endoxifen
Purity
≥98% (mixture of isomers)
Packaging
25mg
Price
$765
Updated
2024/03/01
TRC
Product number
D292043
Product name
N-Desmethyl-4-hydroxyTamoxifen(approx.1:1E/ZMixture)
Packaging
25mg
Price
$580
Updated
2021/12/16
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N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) Chemical Properties,Usage,Production

Chemical Properties

Brown Foam

Uses

A novel active metabolite of the anti-cancer drug Tamoxifen. It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast ca

Uses

A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.

in vivo

Orally administered Endoxifen is rapidly absorbed and systemically available when tested in female rats. The Endoxifen-treated rats show 787% higher exposure (AUC0–∞) and 1,500% higher concentration (Cmax) levels of Endoxifen when compared with Tamoxifen. Oral Endoxifen administration once a day for 28 consecutive days at dosages 2, 4, and 8 mg/kg proves safe and results in progressive inhibition of the growth of the human mammary tumor xenografts in female mice[2].

IC 50

Aromatase; ERα

storage

Store at +4°C

N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) Suppliers

Canada 1 China 74 India 3 United States 9 Global 87
Beijing LAL Pharmaceutical Co., Ltd.
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110025-28-0, N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)Related Search:

4Hydroxy Tamoxifen Tamoxifen EP Impurity D (E)-4-Alloxycarboxyl Tamoxifen desdimethyltamoxifen TAMOXIFEN-N-OXIDE Droloxifene (E)-4-Acetoxy Tamoxifen N-Desmethyl Tamoxifen Methanethiosulfonate 2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine alpha-[4-[2-(dimethylamino)ethoxy]phenyl]-beta-ethyl-alpha-phenylphenethyl alcohol (E)-4-Hydroxy-N-desmethyl Tamoxifen 4-HYDROXYTAMOXIFEN N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture) 1-(4-(2-Dimethylamino)-2-ethoxyphenyl butanone TaMoxifen DiMer 4-Benzyloxy β-Hydroxy TaMoxifen Tamoxifen Impurity 3 Avacopan

  • 4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol
  • 4OHNDtam
  • E/Z Endoxifen
  • N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
  • 4-hydroxy-N-desmethyltamoxifen
  • 4-[(E)-1-[4-(2-methylaminoethoxy)phenyl]-2-phenyl-but-1-enyl]phenol
  • 4-[(Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol
  • N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) see H938500
  • (E /Z) Endoxifen HCl
  • Endoxifen (Z/E=3:2)
  • 4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
  • Endoxifen(EE/Z=1:1)
  • Endoxifen（E/Z=1: 1）
  • 4-Hydroxy-N-Desmethyl Tamoxifen ((E/Z)-Endoxifen)
  • Phenol,4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
  • CS-2602
  • (E/Z)-N-desmethyl-4-hydroxy Tamoxifen
  • 4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
  • 4-Hydroxy-N-Desmethyl Tamoxifen (Endoxifen) (Mixture of Z and E Isomers)
  • Tamoxifen Citrate Impurity 11 (4-Hydroxy-N-Desmethyl Tamoxifen) (Mixture of Z and E Isomers)
  • Tamoxifen Impurity 16
  • inhibit,Parasite,Aromatase,Endoxifen,Inhibitor,Drug Metabolite,Estrogen Receptor/ERR
  • 4-Hydroxy Endoxifen
  • Endoxifen, 10 mM in DMSO
  • Tamoxifen Citrate Impurity 10
  • 4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol(approx. 1:1 E/Z Mixture)
  • 4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenoll
  • 110025-28-0
  • Aromatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals