2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid

Product Name: 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
CAS No.: 116371-67-6
Chemical Name: 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
Synonyms: Gemcitabine Impurity 37;Gemcitabine Monophosphate;Gemcitabine-5′,-monophosphate;Gemcitibine monophosphate formate salt;Gemcitabine Monophosphate Formate Salt;Gemcitabine-5'-monophosphate Free acid;2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid;5'-Cytidylic acid, 2'-deoxy-2',2'-difluoro-;2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate;2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid ForMate
CBNumber: CB31873080
Molecular Formula: C9H12F2N3O7P
Formula Weight: 343.18
MOL File: 116371-67-6.mol

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2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Property

Melting point:: 151-153?C
Boiling point:: 618.3±65.0 °C(Predicted)
Density: 2.09
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: DMSO (Slightly), Water (Slightly)
form: Solid
pka: 1.86±0.10(Predicted)
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: G305005
Product name: GemcitabineMonophosphate
Packaging: 1mg
Price: $120
Updated: 2021/12/16

TRC

Product number: G305005
Product name: GemcitabineMonophosphate
Packaging: 5mg
Price: $330
Updated: 2021/12/16

Usbiological

Product number: 296171
Product name: Gemcitabine Monophosphate, Formate salt
Packaging: 5mg
Price: $708
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000579
Product name: GEMCITABINE MONOPHOSPHATE
Purity: 95.00%
Packaging: 1MG
Price: $750.75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NG16551
Product name: 2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate formate salt
Packaging: 25mg
Price: $800
Updated: 2021/12/16

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2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent.

Uses

Gemcitabine derivative. An antineoplastic agent

in vivo

Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis^[1].

Animal Model:	Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer^[1]
Dosage:	19.5 mg/kg, every other day, four injections
Administration:	Intravenous injection (i.v.)
Result:	Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis.

2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Suppliers

Canada 1 China 62 China Hong Kong 1 India 3 United Kingdom 1 United States 9 Global 77

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
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BeiJing TOP Science Bio-Technology Co., Ltd.

Tel: +86-13439059536 +86-15201677815
Email: 2638315663@qq.com
Country: China
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Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
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Shanghai Macklin Biochemical Co.,Ltd.

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Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
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Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
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Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@yongstandards.com
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Shanghai BetterBioChem Co., Ltd.

Tel: +86-18017644823
Fax: - QQ：1910610264
Email: sales@betterbiochem.com
Country: China
ProdList: 325
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116371-67-6, 2'-Deoxy-2',2'-difluoro-5'-cytidylic AcidRelated Search:

Gemcitabine

2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid

Gemcitabine Monophosphate

2',2'-Difluoro-2'-deoxycytidine 5'-phosphoric acid

2',2'-Difluoro-2'-deoxycytidine-5'-phosphoric acid

Gemcitabine Monophosphate Formate Salt

2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid ForMate

GeMcitabine Monophosphate disodiuM salt Monohydrate

2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate formate salt

Gemcitibine monophosphate formate salt

2'-Deoxy-2',2'-difluorocytidine monophosphate formate salt

5'-Cytidylic acid, 2'-deoxy-2',2'-difluoro-

((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate

Gemcitabine-5'-monophosphate Free acid

Gemcitabine Impurity 37

Gemcitabine-5&#8242,-monophosphate

2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate

116371-67-6

C9H12F2N3O7P

C9H12F2N3O7P25

C10H14F2N3O9P

Intermediates & Fine Chemicals

Pharmaceuticals

Phosphorylating and Phosphitylating Agents

Bases & Related Reagents

Nucleotides