2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
- Product Name
- 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
- CAS No.
- 116371-67-6
- Chemical Name
- 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
- Synonyms
- Gemcitabine Impurity 37;Gemcitabine Monophosphate;Gemcitabine-5′,-monophosphate;Gemcitibine monophosphate formate salt;Gemcitabine Monophosphate Formate Salt;Gemcitabine-5'-monophosphate Free acid;2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid;5'-Cytidylic acid, 2'-deoxy-2',2'-difluoro-;2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate;2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid ForMate
- CBNumber
- CB31873080
- Molecular Formula
- C9H12F2N3O7P
- Formula Weight
- 343.18
- MOL File
- 116371-67-6.mol
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Property
- Melting point:
- 151-153?C
- Boiling point:
- 618.3±65.0 °C(Predicted)
- Density
- 2.09
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- DMSO (Slightly), Water (Slightly)
- form
- Solid
- pka
- 1.86±0.10(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- G305005
- Product name
- GemcitabineMonophosphate
- Packaging
- 1mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- G305005
- Product name
- GemcitabineMonophosphate
- Packaging
- 5mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 296171
- Product name
- Gemcitabine Monophosphate, Formate salt
- Packaging
- 5mg
- Price
- $708
- Updated
- 2021/12/16
- Product number
- API0000579
- Product name
- GEMCITABINE MONOPHOSPHATE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $750.75
- Updated
- 2021/12/16
- Product number
- NG16551
- Product name
- 2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate formate salt
- Packaging
- 25mg
- Price
- $800
- Updated
- 2021/12/16
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent.
Uses
Gemcitabine derivative. An antineoplastic agent
in vivo
Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis[1].
| Animal Model: | Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer[1] |
| Dosage: | 19.5 mg/kg, every other day, four injections |
| Administration: | Intravenous injection (i.v.) |
| Result: | Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis. |
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Suppliers
- Tel
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- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
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