tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate
- Product Name
- tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate
- CAS No.
- 305329-97-9
- Chemical Name
- tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate
- Synonyms
- N-Boc-3-Bromomethylpyrroline;Boc-3-Bromomethyl-pyrrolidine;N-BOC-3-BROMOMETHYLPYRROLIDINE;1-N-Boc-3-broMoMethylpyrrolidine;1-Boc-3-(broMoMethyl)pyrrolidine;REF DUPL: Boc-3-Bromomethyl-pyrrolidine;t-butyl-3-(bromomethyl)pyrrolidine-1-carboxylate;tert-butyl 3-(brommethyl)pyrrolidine-1-carboxylate;TERT-BUTYL 3-(BROMOMETHYL)PYRROLIDINE-1-CARBOXYLATE;3-BROMOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CBNumber
- CB3188484
- Molecular Formula
- C10H18BrNO2
- Formula Weight
- 264.16
- MOL File
- 305329-97-9.mol
tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate Property
- Boiling point:
- 300.1±15.0 °C(Predicted)
- Density
- 1.312±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.14±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B695283
- Product name
- tert-Butyl3-(Bromomethyl)pyrrolidine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 057308
- Product name
- tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 057308
- Product name
- tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate
- Purity
- 95%
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB56661
- Product name
- tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate
- Packaging
- 50mg
- Price
- $77
- Updated
- 2021/12/16
- Product number
- FB56661
- Product name
- tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate
- Packaging
- 100mg
- Price
- $123
- Updated
- 2021/12/16
tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Liquid
Synthesis
114214-69-6
305329-97-9
The general procedure for the synthesis of 1-Boc-3-(bromomethyl)pyrrolidine from 1-Boc-3-hydroxymethylpyrrolidine was as follows: 1,1-dimethylethyl-3-(hydroxymethyl)-1-pyrrolidine carboxylate (0.56 g, 2.8 mmol) was dissolved in dichloromethane (10 mL) under the protection of nitrogen and carbon tribromide (1.39 g, 4.2 mmol) was added. Subsequently, a solution of triphenylphosphine (0.73 g, 2.8 mmol) in dichloromethane (5 mL) was added slowly and dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in a 10% ethyl acetate/90% hexane solvent mixture, stirred and filtered. The filtrate was purified by silica gel column chromatography using a gradient elution of 0-25% ethyl acetate/hexane, and the target fraction was collected to give 1-Boc-3-(bromomethyl)pyrrolidine (0.41 g, 55% yield). Mass spectrum (electrospray positive ion mode) m/z 264 ([M+H]+).
References
[1] Patent: WO2007/58850, 2007, A2. Location in patent: Page/Page column 52-53
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 18, p. 5663 - 5679
[3] Patent: WO2008/121685, 2008, A1. Location in patent: Page/Page column 46
[4] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 1151 - 1175
tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate manufacturers
- Product
- tert-Butyl 3-(bromomethyl)pyrrolidine-1-carboxylate 305329-97-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25