(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE

Product Name: (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE
CAS No.: 15295-77-9
Chemical Name: (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE
Synonyms: AKOS 354;l-(-)-à-amino-;H-L-Hse-lactone*HBr;HOMOSERINE LACTONE HBR;(3S)-3-aminooxolan-2-one;L-Homoserine lactone HBr;(S)-3-Aminodihydrofuran-2;2-(METHYLAMINO)ETHANOL, 98+%;Homoserine lactone (HBr Salt);L-HOMOSERINE LACTONE HYDROBROMIDE
CBNumber: CB3197778
Molecular Formula: C4H8BrNO2
Formula Weight: 182.02
MOL File: 15295-77-9.mol

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(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE Property

Melting point:: 225 °C (dec.)(lit.)
storage temp.: 2-8°C
solubility: Methanol (Slightly), Water (Slightly)
form: Liquid
color: Clear yellow to brownish, may darken on storage
optical activity: [α]20/D 21°, c = 1 in H2O
Sensitive: Hygroscopic
BRN: 3912375
CAS DataBase Reference: 15295-77-9(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 22-24/25-37/39-26
WGK Germany: 3
F: 3-10
HS Code: 29420000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 471429
Product name: (S)-(?)-α-Amino-γ-butyrolactone hydrobromide
Purity: 99%
Packaging: 5g
Price: $168
Updated: 2025/07/31

TRC

Product number: H615105
Product name: L-HomoserineLactoneHydrobromide
Packaging: 1g
Price: $55
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK225549
Product name: (S)-(-)-alpha-Amino-gamma-butyrolactonehydrobromide
Purity: 98%
Packaging: 1g
Price: $58
Updated: 2021/12/16

Adipogen Life Sciences

Product number: CDX-H0310-G005
Product name: L-Homoserinelactonehydrobromide
Purity: ≥95%(NMR)
Packaging: 5G
Price: $112
Updated: 2021/12/16

Matrix Scientific

Product number: 096964
Product name: (S)-3-Aminodihydrofuran-2(3H)-one hydrobromide
Purity: 98%
Packaging: 1g
Price: $114
Updated: 2021/12/16

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(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE Chemical Properties,Usage,Production

Chemical Properties

WHITE TO SLIGHTLY YELLOW CRYSTALLINE POWDER

Uses

L-Homoserine Lactone Hydrobromide is a reactant in the synthesis of tritium labeled and photoactivatable N-acyl-L-homoserine lactones.

Uses

Used to prepare pseudopeptide inhibitors for Ras farnesyl-protein transferase as well as selenomethionine.

Synthesis

63-68-3

6305-38-0

General procedure for the synthesis of α-amino-gamma-butyrolactone hydrobromide from L-methionine: Bromoacetic acid (46.0 kg), 2-propanol (69.0 kg), and acetic acid (69.0 kg) were sequentially added to an aqueous solution (69 kg) of L-methionine (46 kg) at ambient temperature. The resulting mixture was heated to reflux (85 °C to 95 °C) and stirred continuously at this temperature until the completion of the reaction was confirmed by 1H NMR. After completion of the reaction, the mixture was concentrated under reduced pressure and co-evaporated with 2-propanol. To the concentrated mixture was added 2-propanol (161.0 kg) followed by the slow addition of a 10 wt% HCl/dioxane solution (102 kg) at ambient temperature. The resulting slurry was heated to about 60°C and stirred for about 4 hours. Subsequently, the mixture was cooled to about 22°C and stirring was continued for about 2 hours. Filtration gave the product α-amino-γ-butyrolactone hydrobromide (Ma), which was was washed with two portions of 2-propanol (28 kg each) and dried under vacuum at 40 °C to give a white to off-white solid (39.3 kg, 70% yield).The 1H NMR (D2O) data were as follows: δ 4.79 (s, 2H), 4.61 (dd, 1H), 4.49-4.41 (m. 2H), 2.80 (m, 1H), 2.42 (m, 1H).

References

[1] Organic and Biomolecular Chemistry, 2013, vol. 11, # 6, p. 938 - 954
[2] Organic and Biomolecular Chemistry, 2005, vol. 3, # 2, p. 253 - 262
[3] Molecules, 2013, vol. 18, # 3, p. 3266 - 3278
[4] Journal of the American Chemical Society, 2018, vol. 140, # 9, p. 3242 - 3249
[5] Patent: US2010/256366, 2010, A1. Location in patent: Page/Page column 20

(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE Suppliers

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View Lastest Price from (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE manufacturers

R&D Scientific Inc.

Product: (S)-3-Aminodihydrofuran-2(3H)-one hydrobromide 15295-77-9
Price: US $380.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-02-21

Longyan Tianhua Biological Technology Co., Ltd

Product: (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACT 15295-77-9
Price: US $15.00/Kg/Bag
Min. Order: 25Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-11-03

15295-77-9, (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDERelated Search:

Gamma Butyrolactone Hydrogen bromide (-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE,ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE,D,L-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE 3-FURANAMINE, TETRAHYDRO- (S)-3-AMINOTETRAHYDROFURAN 3-AMINODIHYDRO-2(3H)-FURANONE HYDROIODIDE L-Homoserine lactone hydrochloride L-HOMOSERINE LACTONE, HYDROCHLORIDE

AKOS 354

L-HOMOSERINE LACTONE HYDROBROMIDE

L-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE

HOMOSERINE LACTONE HBR

(S)-(-)-2-AMINO-4-BUTYROLACTONE HYDROBROMIDE

(S)-2-AMINO-4-BUTYROLACTONE HYDROBROMIDE

(S)-(-)-alpha-Amino-gamma-butyrolactone hydrobromide 99%

L-(-)-ALPHA-AMINO--BUTYROLACTONE HYDROBROMIDE

H-L-Hse-lactone*HBr

L-Homoserine lactone, (S)-2-Amino-4-butyrolactone hydrobromide

Homoserine lactone (HBr Salt)

L-(-)-ɑ-Amino-γ-butyrolactone hydrobromide, 98%

L-(-)-^a-Amino-^y-butyrolactone hydrobromide, 98%

(S)-(-)-alpha-Amino-gamma-butyrolactone hydrobromide,98%

L-(-)-alpha-Amino-gamma-butyrolactone

(S)-()-α-Amino-γ-butyrolactone hydrobromide,L-Homoserine lactone hydrobromide

(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE

2-(METHYLAMINO)ETHANOL, 98+%

(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROIODIDE

(s)-(-)-α-amino-γ-butyrolactone hydrobromide

l-(-)-à-amino-

(3S)-3-aminooxolan-2-one

(S)-3-Aminodihydrofuran-2

L-Homoserine lactone HBr

(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HBR

2(3H)-Furanone, 3-aMinodihydro-, hydrobroMide, (3S)-

(S)-(-)-alpha-Aminobutyrolactone hydrobromide

(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACT

(S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE USP/EP/BP

(3S)-3-aMinooxolan-2-one hydrobromide

(S)-2-oxotetrahydrofuran-3-aminium bromide

L - (-) - α - amino - γ - butyrolactone hydrobromate

(S)-3-Aminodihydro-2(3H)-Furanonehydrobromide

3S-3-aminodihydrofuran-2(3H)-one hydrobromide

(<i>S</i>)-(?)-α-Amino-γ-butyrolactone hydrobromide

(S)-(?)-α-Amino-γ-butyrolactone hydrobromide

15295-77-9

Specialty Synthesis

Unnatural Amino Acid Derivatives

Peptide Synthesis

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Asymmetric Synthesis

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