ChemicalBook > CAS DataBase List > METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE

METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE

Product Name
METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE
CAS No.
53871-06-0
Chemical Name
METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE
Synonyms
METHYL 1-BENZHYDRYLAZETIDINE-3-CARBOXYLATE;BUTTPARK 37\04-18;Methyl 1-diphenylMethyl-a...;Methyl 1-(diphenylmethyl)-3-azetidinecarboxylate;METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE;N-BENZHYDRYLAZETIDINE-3-CARBOXYLIC ACID METHYL ESTER;1-BENZHYDRYL-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER;Methyl 1-diphenylmethyl-azetidine-3-carboxylate - [M1904];1-(Diphenylmethyl)azetidine-3-carboxylic acid methyl ester;3-AZETIDINECARBOXYLIC ACID, 1-(DIPHENYLMETHYL)-, METHYL ESTER
CBNumber
CB3199020
Molecular Formula
C18H19NO2
Formula Weight
281.35
MOL File
53871-06-0.mol
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METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE Property

Melting point:
67-70°C
Boiling point:
366℃
Density 
1.163
Flash point:
122℃
storage temp. 
Sealed in dry,Room Temperature
pka
6.41±0.10(Predicted)
Appearance
White to light brown Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
M218793
Product name
Methyl1-(Diphenylmethyl)azetidine-3-carboxylate
Packaging
500mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-3P
Product name
Methyl 1-(diphenylmethyl)azetidine-3-carboxylate
Packaging
1g
Price
$38
Updated
2021/12/16
Synthonix
Product number
M1904
Product name
Methyl1-diphenylmethyl-azetidine-3-carboxylate
Purity
97.0%
Packaging
5g
Price
$50
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-3P
Product name
Methyl 1-(diphenylmethyl)azetidine-3-carboxylate
Packaging
5G
Price
$58
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078988
Product name
METHYL-1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE
Purity
95.00%
Packaging
1G
Price
$130.2
Updated
2021/12/16
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METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

36476-87-6

74-88-4

53871-06-0

GENERAL STEPS: Potassium carbonate (6.53 g, 47.2 mmol) and iodomethane (0.976 mL, 15.7 mmol) were sequentially added to a solution of N,N-dimethylformamide (45 mL) of 1-diphenylmethylazetidine-3-carboxylic acid (4.20 g, 15.7 mmol) and the reaction was stirred at room temperature for 20.5 hours. After completion of the reaction, the reaction mixture was slowly poured into ice water and extracted with ethyl acetate (3 × 50 mL). The organic layers were combined, washed with saturated saline (50 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (elution gradient: heptane/ethyl acetate = 5:1 to 3:1). The fraction containing the target compound was collected and concentrated under reduced pressure to give methyl 1-diphenylmethylazetidine-3-carboxylate (3.57 g, 80.8% yield) as yellow crystals.1H NMR (400 MHz, CDCl3) δ: 3.26 (m, 2H), 3.31 (m, 1H), 3.44 (m, 2H), 3.69 (s, 3H), 4.38 (s, 1H), 7.16-7.16-7.16 1H), 7.16-7.20 (m, 2H), 7.25-7.28 (m, 4H), 7.39-7.41 (m, 4H). ESI-MS m/z: 282 [M + H]+.

References

[1] Patent: US2008/214815, 2008, A1. Location in patent: Page/Page column 14
[2] Patent: EP1889836, 2008, A1. Location in patent: Page/Page column 80

METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE manufacturers

Career Henan Chemical Co
Product
METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE 53871-06-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-02-13

53871-06-0, METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATERelated Search:

1-Diphenylmethylazetidine 1-ISOPROPYLAZETIDINE-3-CARBOXYLIC ACID 1-Benzhydrylazetidine-3-carboxylic acid 1-BENZHYDRYL-AZETIDINE-3-CARBOXYLIC ACID ETHYL ESTER METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE N-Benzyl-3-(hydroxymethyl)azetidine azetidine-3-carboxylic acid methyl ester 1-Benzyl-3-azetidinecarboxylic acid METHYL 3-(1-PHENYLETHYLAMINO)PROPANOATE 3-Azetidinecarboxylic acid Methyl N-benzylazetidine-3-carboxylate 1-(DIPHENYLMETHYL)-3-(HYDROXYMETHYL)AZETIDINE

  • 1-BENZHYDRYL-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER
  • METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE
  • BUTTPARK 37\04-18
  • METHYL 1-BENZHYDRYLAZETIDINE-3-CARBOXYLATE
  • N-BENZHYDRYLAZETIDINE-3-CARBOXYLIC ACID METHYL ESTER
  • Methyl 1-diphenylMethyl-a...
  • Methyl 1-benzhydrylazetidine-3-carboxylate, Methyl 1-benzhydrylazetane-3-carboxylate
  • 1-(Diphenylmethyl)azetidine-3-carboxylic acid methyl ester
  • 3-AZETIDINECARBOXYLIC ACID, 1-(DIPHENYLMETHYL)-, METHYL ESTER
  • Methyl 1-(diphenylmethyl)-3-azetidinecarboxylate
  • Methyl 1-diphenylmethyl-azetidine-3-carboxylate - [M1904]
  • 53871-06-0