ChemicalBook > CAS DataBase List > BOC-8-AMINOCAPRYLIC ACID

BOC-8-AMINOCAPRYLIC ACID

Product Name: BOC-8-AMINOCAPRYLIC ACID
CAS No.: 30100-16-4
Chemical Name: BOC-8-AMINOCAPRYLIC ACID
Synonyms: BOC-8-AOC-OH;BOC-AOC(8)-OH;BOC-NH-(CH2)7-COOH;RARECHEM EM WB 0025;BOC-AMINOCAPRYLIC ACID;Boc-8-aminooctanoicaci;BOC-8-AMINOOCTANOIC ACID;BOC-8-AMINOCAPRYLIC ACID;8-(BOC-AMINO)OCTANOIC ACID;8-(BOC-AMINO)CAPRYLIC ACID
CBNumber: CB3201086
Molecular Formula: C13H25NO4
Formula Weight: 259.34
MOL File: 30100-16-4.mol

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BOC-8-AMINOCAPRYLIC ACID Property

Melting point:: 56-59 °C
Boiling point:: 406.0±28.0 °C(Predicted)
Density: 1.036±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 4.78±0.10(Predicted)
form: Solid
Appearance: White to off-white Solid
BRN: 2268966
InChI: InChI=1S/C13H25NO4/c1-13(2,3)18-12(17)14-10-8-6-4-5-7-9-11(15)16/h4-10H2,1-3H3,(H,14,17)(H,15,16)
InChIKey: FPRZYWCRQHFPSX-UHFFFAOYSA-N
SMILES: C(O)(=O)CCCCCCCNC(OC(C)(C)C)=O

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Safety

WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: B657178
Product name: Boc-8-Aoc-OH
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B657178
Product name: Boc-8-Aoc-OH
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 264967
Product name: Boc-8-aminocaprylic acid
Packaging: 1g
Price: $366
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB48262
Product name: Boc-8-aminocaprylic acid
Packaging: 10g
Price: $535.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002954
Product name: 8-(BOC-AMINO)CAPRYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $702.24
Updated: 2021/12/16

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BOC-8-AMINOCAPRYLIC ACID Chemical Properties,Usage,Production

Description

Boc-8-aoc-oh can be used as a PROTAC linker in the synthesis of PROTACs. Boc-8-aoc-oh is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

White amorphous powder

Uses

Reagent to introduce a protected w-amino alkyl spacer. Longer spacer arms often impart increased activity to the substrate

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

1002-57-9

24424-99-5

30100-16-4

GENERAL METHOD: Di-tert-butyl dicarbonate ((Boc)2O, 11.0 mmol) was dissolved in acetone (5 mL) and slowly added dropwise to a stirred acetone-water mixture (v:v 1:1, 20 mL) of 8-aminooctanoic acid (10.0 mmol) and triethylamine (Et3N, 20.0 mmol). The reaction mixture was stirred continuously at room temperature for 4-8 hours until complete consumption of 8-aminooctanoic acid was confirmed by thin layer chromatography (TLC) detection. Subsequently, the organic solvent was removed under reduced pressure and the remaining aqueous phase was adjusted to pH 4-5 with dilute hydrochloric acid. the aqueous phase was extracted with ethyl acetate (EtOAc), and the combined organic phases were washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). Finally, the organic phase was concentrated under reduced pressure and the product was freeze-dried at -80 °C to obtain Boc-8-aminooctanoic acid.

References

[1] Journal of Asian Natural Products Research, 2017, vol. 19, # 3, p. 272 - 298
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 4, p. 402 - 407
[3] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 12, p. 1964 - 1972
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 2, p. 718 - 738
[5] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4696 - 4703

BOC-8-AMINOCAPRYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-8-AMINOCAPRYLIC ACID manufacturers

Career Henan Chemical Co

Product: BOC-8-AMINOCAPRYLIC ACID 30100-16-4
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-09

Career Henan Chemical Co

Product: FMOC-(S)-3-AMINO-5-HEXYNOIC ACID 30100-16-4
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-09

30100-16-4, BOC-8-AMINOCAPRYLIC ACIDRelated Search:

2-(2-Carboxyethyl)piperidine-1-carboxylic acid tert-butyl ester 8-Aminooctanoic acid BOC-8-AMINOCAPRYLIC ACID 4-(1-BOC-PIPERIDIN-3-YL)-BUTYRIC ACID (S)-N-4-FMOC-N-8-BOC-DIAMINOOCTANOIC ACID (1R,3R,4S,6S)-4-TERT-BUTOXYCARBONYLAMINO-4,7,7-TRIMETHYL-BICYCLO[4.1.0]HEPTANE-3-CARBOXYLIC ACID FMOC-D, L-TRANS-CHA(4-CH2NH-BOC) N-(BOC)-(3S,6S,9S)-2-OXO-3-AMINO-1-AZA-BICYCLO[4.3.0]-NONANE-9-CARBOXYLIC ACID 3-(1-(TERT-BUTOXYCARBONYL)PYRROLIDIN-3-YL)CYCLOHEXANECARBOXYLIC ACID TERT-BUTYL 3-(3-(ETHOXYCARBONYL)-2-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE 4-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)CYCLOHEXANECARBOXYLIC ACID 2-BOC-AMINOCYCLOHEPTANECARBOXYLIC ACID (S)-A-FMOC-8-BOCAMINO-OCTANOIC ACID (S)-TRANS-4-(T-BUTYLOXYCARBONYL-AMINOMETHYL)-CYCLOHEXYLALANINE L-TRANS-CHA(4-CH2NH-BOC)-HCL 4-(1-(TERT-BUTOXYCARBONYL)PYRROLIDIN-3-YL)CYCLOHEXANECARBOXYLIC ACID BOC-(5R)-INDOLIZIDIN-9-ONE AMINO ACID 2-(2-METHOXYCARBONYL-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

RARECHEM EM WB 0025

T-BUTOXYCARBONYL-8-AMINOCAPRYLIC ACID

T-BUTOXYCARBONYL-8-AMINOOCTANOIC ACID

N-TERT-BUTYLOXYCARBONYL-8-AMINO-OCTANOIC ACID

8-(BOC-AMINO)CAPRYLIC ACID

8-(BOC-AMINO)OCTANOIC ACID

BOC-NH-(CH2)7-COOH

BOC-AMINOCAPRYLIC ACID

BOC-AOC(8)-OH

BOC-8-AMINOCAPRYLIC ACID

BOC-8-AMINOOCTANOIC ACID

BOC-8-AOC-OH

N-T-BUTYLOXYCARBONYL-8-AMINO-OCTANOIC ACID

Boc-8-aminooctanoic acid (Boc-aminocaprylic acid)

8-(Boc-amino)caprylic acid, 8-(Boc-amino)octanoic acid

8-[[(1,1-dimethylethoxy)carbonyl]amino]Octanoic acid

N-Boc-8-amino-octanoic acid

Boc-8-aminocaprylic acid≥ 97% (HPLC)

(Tert-Butoxy)Carbonyl 8-Aoc-OH

Octanoicacid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-

Boc-8-aminooctanoicaci

BOC-8-AMINOCAPRYLIC ACID USP/EP/BP

Boc-8-Aoc-OH Boc-8-aminocaprylic acid

8-(tert-butoxycarbonylamino)octanoic acid - [B86430]

30100-16-4

30100-10-4

CH33CO2CNHCH27CO2H

Peptide Synthesis

Linear Core Amino Acids

Specialty Synthesis

Unnatural Amino Acid Derivatives

Amino Acids