BOC-8-AMINOCAPRYLIC ACID
- Product Name
- BOC-8-AMINOCAPRYLIC ACID
- CAS No.
- 30100-16-4
- Chemical Name
- BOC-8-AMINOCAPRYLIC ACID
- Synonyms
- BOC-8-AOC-OH;BOC-AOC(8)-OH;BOC-NH-(CH2)7-COOH;RARECHEM EM WB 0025;BOC-AMINOCAPRYLIC ACID;Boc-8-aminooctanoicaci;BOC-8-AMINOOCTANOIC ACID;BOC-8-AMINOCAPRYLIC ACID;8-(BOC-AMINO)OCTANOIC ACID;8-(BOC-AMINO)CAPRYLIC ACID
- CBNumber
- CB3201086
- Molecular Formula
- C13H25NO4
- Formula Weight
- 259.34
- MOL File
- 30100-16-4.mol
BOC-8-AMINOCAPRYLIC ACID Property
- Melting point:
- 56-59 °C
- Boiling point:
- 406.0±28.0 °C(Predicted)
- Density
- 1.036±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 4.78±0.10(Predicted)
- form
- Solid
- Appearance
- White to off-white Solid
- BRN
- 2268966
- InChI
- InChI=1S/C13H25NO4/c1-13(2,3)18-12(17)14-10-8-6-4-5-7-9-11(15)16/h4-10H2,1-3H3,(H,14,17)(H,15,16)
- InChIKey
- FPRZYWCRQHFPSX-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCCCCCCNC(OC(C)(C)C)=O
Safety
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29241990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B657178
- Product name
- Boc-8-Aoc-OH
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B657178
- Product name
- Boc-8-Aoc-OH
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 264967
- Product name
- Boc-8-aminocaprylic acid
- Packaging
- 1g
- Price
- $366
- Updated
- 2021/12/16
- Product number
- FB48262
- Product name
- Boc-8-aminocaprylic acid
- Packaging
- 10g
- Price
- $535.5
- Updated
- 2021/12/16
- Product number
- AAA0002954
- Product name
- 8-(BOC-AMINO)CAPRYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $702.24
- Updated
- 2021/12/16
BOC-8-AMINOCAPRYLIC ACID Chemical Properties,Usage,Production
Description
Boc-8-aoc-oh can be used as a PROTAC linker in the synthesis of PROTACs. Boc-8-aoc-oh is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties
White amorphous powder
Uses
Reagent to introduce a protected w-amino alkyl spacer. Longer spacer arms often impart increased activity to the substrate
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
1002-57-9
24424-99-5
30100-16-4
GENERAL METHOD: Di-tert-butyl dicarbonate ((Boc)2O, 11.0 mmol) was dissolved in acetone (5 mL) and slowly added dropwise to a stirred acetone-water mixture (v:v 1:1, 20 mL) of 8-aminooctanoic acid (10.0 mmol) and triethylamine (Et3N, 20.0 mmol). The reaction mixture was stirred continuously at room temperature for 4-8 hours until complete consumption of 8-aminooctanoic acid was confirmed by thin layer chromatography (TLC) detection. Subsequently, the organic solvent was removed under reduced pressure and the remaining aqueous phase was adjusted to pH 4-5 with dilute hydrochloric acid. the aqueous phase was extracted with ethyl acetate (EtOAc), and the combined organic phases were washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). Finally, the organic phase was concentrated under reduced pressure and the product was freeze-dried at -80 °C to obtain Boc-8-aminooctanoic acid.
References
[1] Journal of Asian Natural Products Research, 2017, vol. 19, # 3, p. 272 - 298
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 4, p. 402 - 407
[3] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 12, p. 1964 - 1972
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 2, p. 718 - 738
[5] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4696 - 4703
BOC-8-AMINOCAPRYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-8-AMINOCAPRYLIC ACID Suppliers
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- Germany
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View Lastest Price from BOC-8-AMINOCAPRYLIC ACID manufacturers
- Product
- BOC-8-AMINOCAPRYLIC ACID 30100-16-4
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-09
- Product
- FMOC-(S)-3-AMINO-5-HEXYNOIC ACID 30100-16-4
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-09