ChemicalBook > CAS DataBase List > 1-BOC-5-AMINO-INDAZOLE

1-BOC-5-AMINO-INDAZOLE

Product Name
1-BOC-5-AMINO-INDAZOLE
CAS No.
129488-10-4
Chemical Name
1-BOC-5-AMINO-INDAZOLE
Synonyms
Besudil impurity 16;N-Boc-5-AMino-Indazole;1-BOC-5-AMINO-INDAZOLE;Belumosudil Impurity 18;1-Boc-5-Amino-1H-Indazole;5-Amino-N-Boc-1H-Indazole;N-(1)-BOC-5-AMINO-INDAZOLE;1H-Indazole-1-carboxylicacid;Impurity 21 of Besudil Mesylate;5-Amino-1H-indazole, N1-BOC protected
CBNumber
CB3201354
Molecular Formula
C12H15N3O2
Formula Weight
233.27
MOL File
129488-10-4.mol
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1-BOC-5-AMINO-INDAZOLE Property

Boiling point:
395.3±34.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
solid
pka
3.08±0.10(Predicted)
Appearance
Brown to red Solid
InChI
InChI=1S/C12H15N3O2/c1-12(2,3)17-11(16)15-10-5-4-9(13)6-8(10)7-14-15/h4-7H,13H2,1-3H3
InChIKey
LRSDPIIWOZRHNJ-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)C2=C(C=C(N)C=C2)C=N1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CVT00047
Product name
N-(1)-Boc-5-aminoindazole
Packaging
1g
Price
$259
Updated
2025/07/31
TRC
Product number
B689775
Product name
tert-Butyl5-Amino-1H-indazole-1-carboxylate
Packaging
1g
Price
$175
Updated
2021/12/16
Usbiological
Product number
265721
Product name
1-Boc-5-amino-indazole
Packaging
250mg
Price
$347
Updated
2021/12/16
Matrix Scientific
Product number
081499
Product name
tert-Butyl 5-amino-1H-indazole-1-carboxylate
Purity
95+%
Packaging
1g
Price
$27
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-A6
Product name
5-Amino-1H-indazole, N1-Boc protected
Packaging
100mg
Price
$32
Updated
2021/12/16
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1-BOC-5-AMINO-INDAZOLE Chemical Properties,Usage,Production

Uses

tert-Butyl 5-Amino-1H-indazole-1-carboxylate is an intermediate to prepare protein kinase inhibitors.

Synthesis

5401-94-5

129488-10-4

General procedure for the synthesis of 5-amino-N-tert-butoxycarbonylindazole from 5-nitroindazole: 10% Pd-C catalyst (0.054 g, 0.051 mmol in Pd) and the carbamate from Example 105 (2.647 g, 10.1 mmol) were suspended in 95% ethanol, and the system was degassed under reduced pressure and the reaction was carried out under hydrogen atmosphere. After 23 hours of reaction, the solvent was removed using a rotary evaporator. Ethyl acetate (20 mL) was added to the reaction mixture and after filtration, the filtrate was slowly concentrated on a rotary evaporator to give 2.335 g (100% yield) of brown solid product.LC-MS (ESI) m/z 134 [M-Boc + H]+.

References

[1] Patent: WO2006/135383, 2006, A2. Location in patent: Page/Page column 123-124
[2] Patent: WO2012/146724, 2012, A2
[3] Patent: US2014/57942, 2014, A1
[4] Patent: WO2014/68035, 2014, A1
[5] Asian Journal of Chemistry, 2014, vol. 26, # 22, p. 7539 - 7543

1-BOC-5-AMINO-INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-5-AMINO-INDAZOLE Suppliers

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View Lastest Price from 1-BOC-5-AMINO-INDAZOLE manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
tert-Butyl 5-amino-1H-indazole-1-carboxylate 129488-10-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-25
Career Henan Chemical Co
Product
1-BOC-5-AMINO-INDAZOLE 129488-10-4
Price
US $1.00/KG
Min. Order
1KG
Purity
97-99%
Supply Ability
1000KGS
Release date
2019-12-18

129488-10-4, 1-BOC-5-AMINO-INDAZOLERelated Search:

1-BOC-5-AMINO-INDAZOLE 1-BOC-6-AMINO-INDAZOLE N-(1)-BOC-5-NITRO-INDAZOLE tert-Butyl 1H-pyrazole-1-carboxylate 3-IODO-5-NITRO-1H-INDAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 5-CYANOAMINO-INDAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-METHYL-1H-INDAZOL-5-AMINE

  • 1-BOC-5-AMINO-INDAZOLE
  • 5-AMINO-INDAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 5-AMINO-1H-INDAZOLE-1-CARBOXYLIC ACID, 1,1 DIMETHYL ETHYL ESTER
  • 1-Boc-5-Amino-1H-Indazole
  • tert-butyl 5-amino-1H-indazole-1-carboxylate
  • N-(1)-BOC-5-AMINO-INDAZOLE
  • 1H-Indazol-5-amine, N1-BOC protected, tert-Butyl 5-amino-1H-indazole-1-carboxylate,5-Amino-1-(tert-butoxycarbonyl)-1H-indazole
  • 1H-Indazole-1-carboxylicacid,5-aMino-,1,1-diMethylethylester
  • tert-butyl 5-aMino-1H-indazol-1-carboxylate
  • 5-Amino-1H-indazole, N1-BOC protected
  • N-Boc-5-AMino-Indazole
  • 5-Amino-N-Boc-1H-Indazole
  • 5-Amino-1H-indazol-1-carboxylic acid tert-butyl ester
  • tert-Butyl 5-aminoindazole-1-carboxylate
  • 5-Amino-indazole-1-carboxylicacidtert-butyleste
  • 1H-Indazole-1-carboxylicacid
  • 1,1-Dimethylethyl 5-amino-1H-indazole-1-carboxylate
  • Besudil impurity 16
  • Impurity 21 of Besudil Mesylate
  • Belumosudil Impurity 18
  • 129488-10-4
  • Building Blocks
  • Indazole