2(5H)-Furanone

Product Name: 2(5H)-Furanone
CAS No.: 497-23-4
Chemical Name: 2(5H)-Furanone
Synonyms: FURANONE;FURAN-2(5H)-ONE;Butenolide;γ-Crotonolactone;2-Furanone;4-Hydroxy-2-butenoic acid gamma-lactone;CARMELAN;2-Butenolide;2H-furan-5-one;Crotonolactone
CBNumber: CB3201475
Molecular Formula: C4H4O2
Formula Weight: 84.07
MOL File: 497-23-4.mol

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2(5H)-Furanone Property

Melting point:: 4-5 °C (lit.)
Boiling point:: 86-87 °C/12 mmHg (lit.)
Density: 1.185 g/mL at 25 °C (lit.)
refractive index: n20/D 1.469(lit.)
FEMA: 4138 | 4-HYDROXY-2-BUTENOIC ACID GAMMA-LACTONE
Flash point:: 214 °F
storage temp.: 2-8°C
solubility: Chloroform, Ethyl Acetate (Slightly)
form: Liquid
color: Clear colorless to pale yellow or amber
Odor: buttery
Odor Type: buttery
Water Solubility: Immiscible with water.
JECFA Number: 2000
BRN: 383585
Stability:: Moisture Sensitive
InChIKey: VIHAEDVKXSOUAT-UHFFFAOYSA-N
LogP: -0.600
CAS DataBase Reference: 497-23-4(CAS DataBase Reference)
NIST Chemistry Reference: 2(5H)-Furanone(497-23-4)
EPA Substance Registry System: 2(5H)-Furanone (497-23-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: LU3453000
F: 8-10
Hazard Note: Irritant
HS Code: 29322980
Hazardous Substances Data: 497-23-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 283754
Product name: 2(5H)-Furanone
Purity: 98%
Packaging: 1g
Price: $89.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 283754
Product name: 2(5H)-Furanone
Purity: 98%
Packaging: 5g
Price: $350
Updated: 2024/03/01

TCI Chemical

Product number: C1078
Product name: gamma-Crotonolactone
Purity: >93.0%(GC)
Packaging: 5mL
Price: $50
Updated: 2024/03/01

TCI Chemical

Product number: C1078
Product name: gamma-Crotonolactone
Purity: >93.0%(GC)
Packaging: 25mL
Price: $180
Updated: 2024/03/01

Alfa Aesar

Product number: L13142
Product name: 2(5H)-Furanone, 96%
Packaging: 1g
Price: $62.65
Updated: 2024/03/01

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2(5H)-Furanone Chemical Properties,Usage,Production

Chemical Properties

Colorless to pale brown-yellow clear liquid

Chemical Properties

2(5H)-Furanone is light brown liquid

Occurrence

Reported found in coffee

Uses

2(5H)-Furanone is employed in the preparation of 5-substituted 2(5H) furanones (gamma-butenolides) catalyzed by bifunctional aminothiourea and aminosquaramide organocatalysts through direct aldol reaction with aromatic aldehydes. Further, it is used in the synthesis of lignans by Michael addition reactions. In addition to this, it is used in three-component Michael-Aldol reactions with an aldehyde and thiolate or carbanion.

Uses

2(5H)-Furanone is a heterocyclic organic compound that is used widely in the synthetic preparation of pharmaceutical goods.

Uses

2(5H)-Furanone is a versatile reagent used in Michael addition reactions1 for synthesis of lignans.2 Also employed in three-component Michael-Aldol reactions with an aldehyde anda thiolate3 or carbanion.4

Definition

2(5H)-Furanone is a mycotoxin that contains an α,β-unsaturated lactone moiety.

General Description

Chiral urea compounds catalyzed hetero-Michael addition reaction of 2(5H)-furanone (γ-crotonolactone) to pyrrolidine. The quorum sensing inhibition activity by 2(5H)-furanone was studied using bioindicator strains.

Hazard

Extremely toxic.

Purification Methods

Fractionally distil the lactone under reduced pressure. IR: (CCl4) 1784 and 1742 cm-1, UV no max above 205nm ( 1160 cm-1 M-1) and 1HR: (CCl3) : 2.15 (pair of triplets 1H), 3.85 (pair of triplets 1H) and 5.03 (triplet 2H). [Price & Judge Org Synth Coll Vol V 255 1973, Smith & Jones Can J Chem 37 2007, 2092 1959, Beilstein 17/9 V 112.]

2(5H)-Furanone Preparation Products And Raw materials

Raw materials

Preparation Products

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2(5H)-Furanone Suppliers

Americas 1 Belgium 2 Canada 1 China 185 Europe 3 Germany 9 India 11 Japan 2 Russia 1 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 6 United States 34 USA 1 Global 259

ChangZhou SIDU chemical Co., Ltd.

Tel: 0519-81291281 18015082300
Fax: 0519-81291281
Email: siduchem@hotmail.com
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Beijing Taiya Jie Technology Development Co., Ltd.

Tel: 021-33690831-8001 13552411790
Fax: 021-33690831
Email: postmaster@tyjchem.cn
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Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

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Country: China
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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

Tel: +49 3493/605464
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Email: sales@intatrade.de
Country: Germany
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Alfa Aesar

Tel: 400-6106006
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Email: saleschina@alfa-asia.com
Country: China
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TCI (Shanghai) Development Co., Ltd.

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Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
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Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
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Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
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View Lastest Price from 2(5H)-Furanone manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2(5H)-Furanone 497-23-4
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-23

Shaanxi Dideu Medichem Co. Ltd

Product: 2(5H)-Furanone 497-23-4
Price: US $30.00-20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 3000KG
Release date: 2024-07-23

JINING XINHE CHEMICAL CO., LTD

Product: 2(5H)-Furanone 497-23-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10ton
Release date: 2024-07-22

497-23-4, 2(5H)-FuranoneRelated Search:

Furan Furazolidone Benzofuran CYMARIN RUBRATOXIN B Citraconic anhydride DIGOXIN CIS-BUTENEDIOIC ANHYDRIDE Dichloromaleic anhydride 2,3-Dimethylmaleic anhydride DIGITOXIGENIN G-STROPHANTHIN Ascorbyl Palmitate Erythorbic Acid CIS-ACONITIC ANHYDRIDE 2,3-DIPHENYLMALEIC ANHYDRIDE 4-Methoxy-2,5-dimethyl-3(2H)-furanone Digitoxin

.alpha.,.beta.-Crotonolactone

γ-Crotonolactone, 2-Buten-1,4-olide

2,5-Dihydrofuranone

5-Oxo-2,5-dihydrofuran-3-yl ester

a,b-Crotonolactone

Crotonic acid, 4-hydroxy-

2,5-Dihydrofuran-2-one

2(5H)-Furanone,γ-Crotonolactone, 2-Buten-1,4-olide

2(5H)-Furanone 2-Oxo-2,5-dihydrofuran

2(5H)-FURANONE FOR SYNTHESIS 1 ML

2-Furanone

2(5H)-Furanone 98%

but-2-en-4-olide

2H-furan-5-one

.delta.,.alpha.,.beta.-Butenolide

.gamma.-Crotolactone

.gamma.-Hydroxycrotonicacidlactone

2(5H)-Furanone (.gamma.-crotonolactone)

AKOS BBS-00003279

FURAN-2(5H)-ONE

FURANONE

GAMMA-CROTONOLACTONE

CARMELAN

2-Buten-4-olide

2-Butenoic acid, 4-hydroxy-, gamma-lactone

2-Butenoic acid-gamma-lactone

2-Butenoicacid,4-hydroxy-,.gamma.-lactone

2-Butenoicacid.gamma.-lactone

2-butenoicacidgamma-lactone

2-Butenolide

2-Oxo-2,5-dihydrofuran(2-[5H]-furanone)

4-Hydroxy-2-butenoic acid gamma-lactone

4-Hydroxy-2-butenoic acid lactone

4-Hydroxy-2-butenoicacid.gamma.-lactone

4-hydroxy-2-butenoicacidgamma-lactone

4-Hydroxy-2-butenoicacidlactone

4-hydroxy-2-butenoicacigamma-lactone

4-hydroxy-crotonicacigamma-lactone

5H-Furan-2-one

alpha,beta-Crotonolactone

Butenolide

Crotonic acid, 4-hydroxy-, gamma-lactone

Crotonicacid,4-hydroxy-,.gamma.-lactone

Crotonolactone

delta,alpha,beta-Butenolide

gamma-Crotolactone

gamma-Hydroxycrotonic acid lactone

gamma-hydroxycrotonicacidlactone

Isocrotonolactone

2-BUTEN-1,4-OLIDE

2-OXO-2,5-DIHYDROFURAN

2(5H)-FURANONE

2,5-DIHYDRO-2-FURANONE

2(5H)-Furanone,98%

5-HYDROFURAN-2-ONE

2-Buten-1,4-olide~gamma-Crotonolactone

g-Crotonolactone

γ-Crotonolactone&gt