ChemicalBook > CAS DataBase List > 3-FLUORO-6-NITRO-O-XYLENE

3-FLUORO-6-NITRO-O-XYLENE

Product Name: 3-FLUORO-6-NITRO-O-XYLENE
CAS No.: 1736-87-4
Chemical Name: 3-FLUORO-6-NITRO-O-XYLENE
Synonyms: -FLUORO-6-NITRO-O-XYLENE;3-FLUORO-6-NITRO-O-XYLENE;2,3-Dimethyl-4-fluoronitrobenzene;4-fluoro-2,3-dimethyl nitrobenzene;3-FLUORO-6-NITRO-1,2-DIMETHYLBENZENE;1-FLUORO-2,3-DIMETHYL-4-NITROBENZENE;1,2-Dimethyl-3-fluoro-6-nitrobenzene;3-Fluoro-1,2-dimethyl-6-nitrobenzene;2,3-dimethyl-4-fluoro-1-nitro-benzene;Benzene,1-fluoro-2,3-diMethyl-4-nitro-
CBNumber: CB3204012
Molecular Formula: C8H8FNO2
Formula Weight: 169.15
MOL File: 1736-87-4.mol

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3-FLUORO-6-NITRO-O-XYLENE Property

Melting point:: 39-42℃
Boiling point:: 110°C/14mmHg(lit.)
Density: 1.225±0.06 g/cm3(Predicted)
Flash point:: >110°(230°F)
storage temp.: Sealed in dry,Room Temperature
form: powder to lump
color: White to Orange to Green

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 2909309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5187
Product name: 2,3-Dimethyl-4-fluoronitrobenzene
Purity: >98.0%(GC)
Packaging: 1g
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: D5187
Product name: 2,3-Dimethyl-4-fluoronitrobenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $141
Updated: 2025/07/31

TRC

Product number: F591463
Product name: 1-Fluoro-2,3-dimethyl-4-nitrobenzene
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F591463
Product name: 1-Fluoro-2,3-dimethyl-4-nitrobenzene
Packaging: 250mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-W003230
Product name: 3-Fluoro-1,2-dimethyl-6-nitrobenzene
Purity: >98.0%
Packaging: 5g
Price: $66
Updated: 2021/12/16

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3-FLUORO-6-NITRO-O-XYLENE Chemical Properties,Usage,Production

Uses

3-Fluoro-6-nitro-o-xylene is mainly used as an intermediate in organic synthesis, especially in the fields of pharmaceutical and pesticide chemistry.

Synthesis

443-82-3

1736-87-4

Example 16: Synthesis of 2-(2,3-dimethyl-4-nitrophenylamino)-2-methylpropan-1-ol 1. fuming nitric acid (1.4 g, 20.3 mmol) was cooled to 0 °C and slowly added to acetic anhydride (2.89 g, 28.4 mmol). 2. the above solution was added dropwise to a cooled (0 °C) solution of 3-fluoro-1,2-dimethylbenzene (1.0 g, 8.1 mmol) in acetic anhydride (4 ml) within 10 min. 3. The reaction mixture was stirred at 0 °C for 25 min and then slowly poured into ice water. 4. The aqueous phase was extracted with EtOAc (3×) and the organic phases were combined and washed sequentially with saturated aqueous solution of dilute NaHCO3 and brine. 5. The organic phase was dried over anhydrous Na2SO4, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (mobile phase: hexane) to obtain 2,3-dimethyl-4-fluoro-1-nitrobenzene 0.74 g (54% yield) as a yellow oil, which was crystallized after standing. 6. The above nitro compound (0.576 g, 3.4 mmol) was mixed with 2-amino-2-methylpropanol (0.61 g, 6.8 mmol) in a reaction tube, sealed and immersed in an oil bath at 160 °C for 5 days. 7. TLC monitoring (unfolding agent: hexane) showed raw material remaining. The reaction mixture was cooled and diluted with EtOAc. 8. Purification by fast silica gel column chromatography (dry on sample; eluent: hexane/EtOAc=6:4) recovered the feedstock 2,3-dimethyl-4-fluoro-1-nitrobenzene 0.34 g (59% recovery) and afforded the target product 2-(2,3-dimethyl-4-nitrophenylamino)-2-methylpropan-1-ol 0.20 g (61% yield based on recovered feedstock).

References

[1] Patent: WO2005/42464, 2005, A1. Location in patent: Page/Page column 38-39
[2] Journal of the Chemical Society, 1963, p. 5554 - 5556

3-FLUORO-6-NITRO-O-XYLENE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-FLUORO-6-NITRO-O-XYLENE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3-FLUORO-6-NITRO-O-XYLENE 1736-87-4
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-26

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Fluoro-6-nitro-o-xylene 1736-87-4
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 tons
Release date: 2020-01-10

Career Henan Chemical Co

Product: 3-FLUORO-6-NITRO-O-XYLENE 1736-87-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-12

1736-87-4, 3-FLUORO-6-NITRO-O-XYLENERelated Search:

ISOBUTANE Xylene 3-FLUORO-5-NITRO-O-XYLENE 3-FLUORO-4-NITRO-O-XYLENE 97% 3-FLUORO-4-NITRO-O-XYLENE 3-FLUORO-6-NITRO-O-XYLENE 3-AMINO-6-FLUORO-1,2-DIMETHYLBENZENE

1-FLUORO-2,3-DIMETHYL-4-NITROBENZENE

3-FLUORO-6-NITRO-1,2-DIMETHYLBENZENE

3-FLUORO-6-NITRO-O-XYLENE

2,3-Dimethyl-4-fluoronitrobenzene

3-Fluoro-6-nitro-o-xylene, 2,3-Dimethyl-1-fluoro-4-nitrobenzene

4-fluoro-2,3-dimethyl nitrobenzene

Benzene,1-fluoro-2,3-diMethyl-4-nitro-

3-Fluoro-1,2-diMethyl-6-nitrobenzene, 98%

3-FLUORO-6-NITRO-O-XYLENE3-FLUORO-6-NITRO-O-XYLENE

2,3-dimethyl-4-fluoro-1-nitro-benzene

3-Fluoro-1,2-dimethyl-6-nitrobenzene,98%

3-FLUORO-6-NITRO-O-XYLENE ISO 9001：2015 REACH

-FLUORO-6-NITRO-O-XYLENE

1,2-Dimethyl-3-fluoro-6-nitrobenzene

3-Fluoro-1,2-dimethyl-6-nitrobenzene

1736-87-4