3-FLUORO-6-NITRO-O-XYLENE
- Product Name
- 3-FLUORO-6-NITRO-O-XYLENE
- CAS No.
- 1736-87-4
- Chemical Name
- 3-FLUORO-6-NITRO-O-XYLENE
- Synonyms
- -FLUORO-6-NITRO-O-XYLENE;3-FLUORO-6-NITRO-O-XYLENE;2,3-Dimethyl-4-fluoronitrobenzene;4-fluoro-2,3-dimethyl nitrobenzene;3-FLUORO-6-NITRO-1,2-DIMETHYLBENZENE;1-FLUORO-2,3-DIMETHYL-4-NITROBENZENE;1,2-Dimethyl-3-fluoro-6-nitrobenzene;3-Fluoro-1,2-dimethyl-6-nitrobenzene;2,3-dimethyl-4-fluoro-1-nitro-benzene;Benzene,1-fluoro-2,3-diMethyl-4-nitro-
- CBNumber
- CB3204012
- Molecular Formula
- C8H8FNO2
- Formula Weight
- 169.15
- MOL File
- 1736-87-4.mol
3-FLUORO-6-NITRO-O-XYLENE Property
- Melting point:
- 39-42℃
- Boiling point:
- 110°C/14mmHg(lit.)
- Density
- 1.225±0.06 g/cm3(Predicted)
- Flash point:
- >110°(230°F)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to lump
- color
- White to Orange to Green
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HazardClass
- 6.1
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D5187
- Product name
- 2,3-Dimethyl-4-fluoronitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- D5187
- Product name
- 2,3-Dimethyl-4-fluoronitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $141
- Updated
- 2025/07/31
- Product number
- F591463
- Product name
- 1-Fluoro-2,3-dimethyl-4-nitrobenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F591463
- Product name
- 1-Fluoro-2,3-dimethyl-4-nitrobenzene
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-W003230
- Product name
- 3-Fluoro-1,2-dimethyl-6-nitrobenzene
- Purity
- >98.0%
- Packaging
- 5g
- Price
- $66
- Updated
- 2021/12/16
3-FLUORO-6-NITRO-O-XYLENE Chemical Properties,Usage,Production
Uses
3-Fluoro-6-nitro-o-xylene is mainly used as an intermediate in organic synthesis, especially in the fields of pharmaceutical and pesticide chemistry.
Synthesis
443-82-3
1736-87-4
Example 16: Synthesis of 2-(2,3-dimethyl-4-nitrophenylamino)-2-methylpropan-1-ol 1. fuming nitric acid (1.4 g, 20.3 mmol) was cooled to 0 °C and slowly added to acetic anhydride (2.89 g, 28.4 mmol). 2. the above solution was added dropwise to a cooled (0 °C) solution of 3-fluoro-1,2-dimethylbenzene (1.0 g, 8.1 mmol) in acetic anhydride (4 ml) within 10 min. 3. The reaction mixture was stirred at 0 °C for 25 min and then slowly poured into ice water. 4. The aqueous phase was extracted with EtOAc (3×) and the organic phases were combined and washed sequentially with saturated aqueous solution of dilute NaHCO3 and brine. 5. The organic phase was dried over anhydrous Na2SO4, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (mobile phase: hexane) to obtain 2,3-dimethyl-4-fluoro-1-nitrobenzene 0.74 g (54% yield) as a yellow oil, which was crystallized after standing. 6. The above nitro compound (0.576 g, 3.4 mmol) was mixed with 2-amino-2-methylpropanol (0.61 g, 6.8 mmol) in a reaction tube, sealed and immersed in an oil bath at 160 °C for 5 days. 7. TLC monitoring (unfolding agent: hexane) showed raw material remaining. The reaction mixture was cooled and diluted with EtOAc. 8. Purification by fast silica gel column chromatography (dry on sample; eluent: hexane/EtOAc=6:4) recovered the feedstock 2,3-dimethyl-4-fluoro-1-nitrobenzene 0.34 g (59% recovery) and afforded the target product 2-(2,3-dimethyl-4-nitrophenylamino)-2-methylpropan-1-ol 0.20 g (61% yield based on recovered feedstock).
References
[1] Patent: WO2005/42464, 2005, A1. Location in patent: Page/Page column 38-39
[2] Journal of the Chemical Society, 1963, p. 5554 - 5556
3-FLUORO-6-NITRO-O-XYLENE Preparation Products And Raw materials
Raw materials
Preparation Products
3-FLUORO-6-NITRO-O-XYLENE Suppliers
- Tel
- --
- Fax
- --
- sales@riccichimica.com
- Country
- Italy
- ProdList
- 2146
- Advantage
- 46
View Lastest Price from 3-FLUORO-6-NITRO-O-XYLENE manufacturers
- Product
- 3-FLUORO-6-NITRO-O-XYLENE 1736-87-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 3-Fluoro-6-nitro-o-xylene 1736-87-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10
- Product
- 3-FLUORO-6-NITRO-O-XYLENE 1736-87-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12