ChemicalBook > CAS DataBase List > H-ALLO-THR-OME HCL

H-ALLO-THR-OME HCL

Product Name: H-ALLO-THR-OME HCL
CAS No.: 79617-27-9
Chemical Name: H-ALLO-THR-OME HCL
Synonyms: H-allo-Thr-OMe;AllO-Thr-Ome.Hcl;L-Allo-Thr-Ome.Hcl;H-ALLO-THR-OME HCL;ALLO-THREONINE-OME HCL;Methyl L-allothreoninate hydrochloride;methyl (2S,3S)-2-amino-3-hydroxybutanoate;L-ALLO-THREONINE METHYL ESTER HYDROCHLORIDE;methyl (2S,3S)-2-amino-3-hydroxybutanoate hydrochloride;(2S,3S)-Methyl 2-aMino-3-hydroxybutanoate hydrochloride
CBNumber: CB3207376
Molecular Formula: C5H12ClNO3
Formula Weight: 169.61
MOL File: 79617-27-9.mol

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H-ALLO-THR-OME HCL Property

Melting point:: 95-97 °C
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Very Slightly)
form: Solid
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Usbiological

Product number: 260680
Product name: L-allo-Threonine methyl ester hydrochloride
Packaging: 500mg
Price: $360
Updated: 2021/12/16

Chem-Impex

Product number: 05847
Product name: L-allo-Threoninemethylesterhydrochloride,98%(NMR)
Purity: 98%(NMR)
Packaging: 250MG
Price: $61.6
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA48641
Product name: L-allo-Threonine methyl ester hydrochloride
Packaging: 500mg
Price: $80
Updated: 2021/12/16

Chem-Impex

Product number: 05847
Product name: L-allo-Threoninemethylesterhydrochloride,98%(NMR)
Purity: 98%(NMR)
Packaging: 1G
Price: $106.4
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA48641
Product name: L-allo-Threonine methyl ester hydrochloride
Packaging: 1g
Price: $125
Updated: 2021/12/16

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H-ALLO-THR-OME HCL Chemical Properties,Usage,Production

Uses

L-allo-Threonine Methyl Ester Hydrochloride Hydrate, is used to prepare inhibitors of hepatitis A virus 3C cysteine proteinase.

Synthesis

67-56-1

28954-12-3

39994-75-7

General procedure for the synthesis of L-threonine methyl ester hydrochloride from methanol and (2S,3S)-2-amino-3-hydroxybutanoic acid: a mixture of (2S,3S)-2-amino-3-hydroxybutanoic acid (5.4 g, 24.6 mmol) and 6N HCl (60 mL) was refluxed for 5 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was extracted with ether (3 x 70 mL) to remove the benzoic acid. The aqueous phase was concentrated to dryness under reduced pressure and the residue was further dried under high vacuum overnight to give crude allo-L-threonine. Methanol (25 mL) was cooled to 0 °C and thionyl chloride (1.80 mL, 25.2 mmol) was added slowly and dropwise. Crude allo-L-threonine was added to the prepared HCl methanol solution and the reaction mixture was heated under reflux conditions for 1 hour. After completion of the reaction, the solvent was removed under vacuum and another batch of HCl methanol solution prepared by the same method was added and the reaction mixture was again heated under reflux for 1 hour. Finally, the solvent was removed in vacuum to give allo-L-threonine methyl ester hydrochloride (4.15 g, 98% overall yield in two steps) as a red solid. The product was identified by 1H NMR (300 MHz, CD3OD): δ 1.27 (d, J = 6.6 Hz, 3H), 4.03 (d, J = 3.3 Hz, 1H), 4.27-4.33 (m, 1H); 13C NMR (75 MHz, CD3OD): δ 17.13,58.17,65.11,167.62; MS ( ESI, positive): m/z 134 [M + H]+.

References

[1] Journal of Organic Chemistry, 2002, vol. 67, # 5, p. 1536 - 1547
[2] Helvetica Chimica Acta, 1957, vol. 40, p. 1531,1544
[3] Journal of Organic Chemistry, 1997, vol. 62, # 21, p. 7364 - 7375
[4] Journal of Organic Chemistry, 2003, vol. 68, # 26, p. 10046 - 10057
[5] Journal of the American Chemical Society, 2007, vol. 129, # 18, p. 6017 - 6021

H-ALLO-THR-OME HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from H-ALLO-THR-OME HCL manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: L-Allo-Thr-Ome.Hcl 79617-27-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-04-03

79617-27-9, H-ALLO-THR-OME HCLRelated Search:

L(+)-allo-Threonine L-allo-Threoninemethylester DL-THREONINE METHYL ESTER HYDROCHLORIDE L-Serine methyl ester hydrochloride H-ALLO-THR-OME HCL

ALLO-THREONINE-OME HCL

H-ALLO-THR-OME HCL

L-ALLO-THREONINE METHYL ESTER HYDROCHLORIDE

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(2S,3S)-Methyl 2-aMino-3-hydroxybutanoate hydrochloride

methyl (2S,3S)-2-amino-3-hydroxybutanoate hydrochloride

methyl (2S,3S)-2-amino-3-hydroxybutanoate

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L-Allo-Thr-Ome.Hcl

AllO-Thr-Ome.Hcl

79617-27-9