ChemicalBook > CAS DataBase List > 2'-Deoxyguanosine

2'-Deoxyguanosine

Product Name: 2'-Deoxyguanosine
CAS No.: 961-07-9
Chemical Name: 2'-Deoxyguanosine
Synonyms: 2;DG;deoxyguanosine;2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one;2'-dG;-O-DMT;NSC 22837;D8415_SIGMA;Guanine, 9-(;Oprea1_013861
CBNumber: CB3209022
Molecular Formula: C10H13N5O4
Formula Weight: 267.24
MOL File: 961-07-9.mol

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2'-Deoxyguanosine Property

Melting point:: 300 °C
Boiling point:: 410.43°C (rough estimate)
Density: 1.3382 (rough estimate)
refractive index: -42 ° (C=0.2, 1mol/L NaOH)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: NH₄OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown
form: powder
pka: 9?+-.0.20(Predicted)
color: White to Off-white
PH: 2.37；9.33
optical activity: Consistent with structure
Water Solubility: Slightly soluble in water.
λmax: 255 (pH 1)
BRN: 39814
InChIKey: OROIAVZITJBGSM-OJFKHTATSA-N
CAS DataBase Reference: 961-07-9(CAS DataBase Reference)
NIST Chemistry Reference: Deoxyguanosine(961-07-9)
EPA Substance Registry System: Guanosine, 2'-deoxy- (961-07-9)

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Safety

Risk Statements: 20/21/22
Safety Statements: 24/25
WGK Germany: 3
RTECS: MF8760000
F: 10-23
TSCA: Yes
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D0052
Product name: 2'-Deoxyguanosine Hydrate
Purity: >98.0%(T)
Packaging: 1g
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: D0052
Product name: 2'-Deoxyguanosine Hydrate
Purity: >98.0%(T)
Packaging: 5g
Price: $150
Updated: 2025/07/31

Cayman Chemical

Product number: 9002864
Product name: 2''-Deoxyguanosine
Packaging: 5g
Price: $88
Updated: 2021/12/16

Cayman Chemical

Product number: 9002864
Product name: 2''-Deoxyguanosine
Packaging: 1g
Price: $35
Updated: 2021/12/16

TCI Chemical

Product number: D0052
Product name: 2'-Deoxyguanosine Hydrate
Purity: >98.0%(T)
Packaging: 25g
Price: $448
Updated: 2025/07/31

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2'-Deoxyguanosine Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

2'-Deoxyguanosine (Deoxyguanosine; dG) is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

Definition

ChEBI: 2'-deoxyguanosine is a purine 2'-deoxyribonucleoside having guanine as the nucleobase. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to a guanosine.

benefits

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is the most commonly used marker of DNA oxidation for the diagnosis of oxidative DNA damage and bipolar disorder (BD), as well as for the prevention of plaque formation and for the inhibition of vascular smooth muscle cell activation through Rac1 inactivation.

Biological Functions

2‘-Deoxyguanosine (2’dGuo) is a purine nucleoside metabolite that has been shown to inhibit proliferation-dependent antigen-specific suppressor T cell (Ts) function in mouse and human systems. 2'dGuo also inhibits mitogen-induced T cell proliferation. Low concentrations (40 gM) of 2'dGuo enhanced phytohemagglutinin- and amantadine A-induced T-cell transformation, possibly due to the inhibition of T-cell function leading to the promotion of T-cell growth factor production. T-cell responses were inhibited only when the concentration of 2'dGuo was toxic to lymphocytes.^[1]

IC 50

Human Endogenous Metabolite

Purification Methods

2'-Deoxyguanosine recrystallises from H2O as the monohydrate. [Brown &C5440 Lythgoe J Chem Soc 1990 1950, L

References

[1] A C HANGLOW; P M L. The effect of 2’deoxyguanosine on human lymphocyte responses. I. 2’deoxyguanosine enhances T lymphocyte responses.[J]. Clinical and experimental immunology, 1985, 59 3: 653-658.

2'-Deoxyguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2'-Deoxyguanosine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.

Product: 2'-Deoxyguanosine 961-07-9
Price: US $10.00-99.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-10-10

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 2'-Deoxyguanosine 961-07-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-08-27

WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)

Product: 2'-Deoxyguanosine monohydrate(2'-dG) 961-07-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%HPLC
Supply Ability: 1000T
Release date: 2025-08-19

961-07-9, 2'-DeoxyguanosineRelated Search:

Deoxycholic acid MELIBIOSE Guanosine Guanine Acyclovir Chloral hydrate Guanosine 5'-monophosphate disodium salt 5'-Guanylic acid DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* Guanylic acid sodium salt 2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA),2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA) 2’-deoxyguanosine5’-phosphat 2’-deoxyguanosine5’-(tetrahydrogentriphosphate N2-ISOBUTYRYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE,N2-ISOBUTYRYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE [5',5''-2H2]2'-DEOXYGUANOSINE MONOHYDRATE 3'-deoxyguanosine monohydrate hydrate hydrazine hydrate

DEOXYGUANOSINE-2'

GUANINE DESOXYRIBOSIDE

2'-DEOXY-D-GUANOSINE

A-2'-DEOXYGUANOSINE

9-(2'-DEOXY-BETA-D-RIBOFURANOSYL)GUANINE

O6-Methyl-2&rsquo

2(acute)-Deoxyguanosine

2-amino-9-(4-hydroxy-5-methylol-tetrahydrofuran-2-yl)-3H-purin-6-one

2-amino-9-[4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3H-purin-6-one

2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

9H-Purin-6-ol, 2-amino-9-(2-deoxy-9-beta-D-ribofuranosyl)-

deoxyephedrinearenol2’-deoxyguanosine

deoxyguanosine

Desoxyguanosine

Guanine deoxy nucleoside

Guanine deoxyriboside

Guanine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-

2-DEOXYGUANOSINE extrapure

9-(2-Deoxy-β-D-ribofuranosyl)guanine, Guanine-2μ-deoxyriboside

Norway saltpeter-15N2

2'-Deoxyguanosine ,98%

2'-Deoxyguanosine mo

2'-DEOXYGUANOSINE:H2O

2’-deoxy-guanosin

Deoxyguanosine Monohydrat

2-aMino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one hydrate

2'-Deoxyguanosine Monohydrate SynonyMs 9-(2-Deoxy-beta-D-ribofuranosyl)guanine hydrate

2-AMino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one

2'-Deoxyguanosine Hydrate, 98.0%(T)

-deoxy-N2-DMF-5&rsquo

-O-DMT

8-Allyloxy-N2-(dimethylaminomethylidene)-2&rsquo

-deoxy Guanosine-13C2,D, Major

O6-(2-Hydroxy-1-methylethyl)-2&rsquo

7-Ethyl-2&rsquo

N2-Methyl-2&rsquo

O6-(2-Hydroxypropyl)-2&rsquo

8-Aza-7-deaza-2&rsquo

2'-Desoxyguanosin

7-Methyl-7-deaza-2&rsquo

N1-Methyl-2&rsquo

8-Oxo-N2-isobutyryl-2&rsquo

8-(4-Amino-phenyl)-2&rsquo

9-(2-Deoxy-β-D-ribofuranosyl)guanine

Guanine-2'-deoxyriboside

2'-DEOXYGUANOSINE CELL CULTURE TESTED

DeoxyguanosineMonohydrate,Isolated

2'-Deoxyguanosine hydrate, 99+%

9-(2-deoxy-á-d-ribofuranosyl)guanine hydrate

guanine-2'-deoxyriboside hydrate

2-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

guaninedeoxyriboside

Guanosine, 2'-deoxy-

NSC 22837

9-(2-Deoxy-beta-D-ribofuranosyl)guanine hydrate

Guanine-2'-deoxyriboside monohydrate