6-bromopyrido[2,3-d]pyrimidin-2-amine
- Product Name
- 6-bromopyrido[2,3-d]pyrimidin-2-amine
- CAS No.
- 882670-89-5
- Chemical Name
- 6-bromopyrido[2,3-d]pyrimidin-2-amine
- Synonyms
- 6-bromopyrido[2,3-d]pyrimidin-2-amine;2-Amino-6-bromopyrido[2,3-d]pyrimidine;Pyrido[2,3-d]pyrimidin-2-amine, 6-bromo-;6-Bromo-pyrido[2,3-d]pyrimidin-2-ylamine
- CBNumber
- CB32123850
- Molecular Formula
- C7H5BrN4
- Formula Weight
- 225.05
- MOL File
- 882670-89-5.mol
6-bromopyrido[2,3-d]pyrimidin-2-amine Property
- Boiling point:
- 422.1±48.0 °C(Predicted)
- Density
- 1.849±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.46±0.30(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B292700
- Product name
- 6-Bromo-pyrido[2,3-d]pyrimidin-2-ylamine
- Packaging
- 100mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- HCH0367863
- Product name
- 6-BROMOPYRIDO[2,3-D]PYRIMIDIN-2-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.11
- Updated
- 2021/12/16
- Product number
- 2015DP
- Product name
- 6-Bromopyrido[2,3-d]pyrimidin-2-amine
- Packaging
- 1g
- Price
- $863
- Updated
- 2021/12/16
- Product number
- A144291
- Product name
- 6-Bromopyrido[2,3-d]pyrimidin-2-amine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 882670895
- Product name
- 6-Bromopyrido[2,3-d]pyrimidin-2-amine
- Packaging
- 100mg
- Price
- $158.1
- Updated
- 2021/12/16
6-bromopyrido[2,3-d]pyrimidin-2-amine Chemical Properties,Usage,Production
Synthesis
875781-15-0
50-01-1
882670-89-5
6-Bromopyrido[2,3-d]pyrimidin-2-amine was synthesized as follows: 5-bromo-2-fluoro-3-formylpyridine (3.0 g, 14.78 mmol), guanidine hydrochloride (1.69 g, 17.74 mmol) and triethylamine (4.48 g, 44.35 mmol) were dissolved in 1-methyl-2-pyrrolidinone (15 mL). The reaction mixture was stirred in a microwave reactor at 180 °C for 15 min. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with deionized water (200 mL) followed by extraction with ethyl acetate (2 x 300 mL). The organic phases were combined, washed sequentially with deionized water (3 × 50 mL) and saturated saline (3 × 50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent ratio of ethyl acetate:petroleum ether=3:1, and the final product was 6-bromopyrido[2,3-d]pyrimidin-2-amine (2.0 g, 60% yield) as yellow solid. Mass spectrometry (electrospray positive ion mode) analysis results: C7H5BrN4 theoretical value [M] is 224,226, measured value [M + H] is 225,227.
References
[1] Patent: WO2014/11900, 2014, A2. Location in patent: Page/Page column 44; 45
6-bromopyrido[2,3-d]pyrimidin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
6-bromopyrido[2,3-d]pyrimidin-2-amine Suppliers
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