ChemicalBook > CAS DataBase List > Glycochenodeoxycholic Acid

Glycochenodeoxycholic Acid

Product Name: Glycochenodeoxycholic Acid
CAS No.: 640-79-9
Chemical Name: Glycochenodeoxycholic Acid
Synonyms: GCDCA;Glycochenodeoxycholate;GCDC;Chenodeoxycholylglycine;Glycinodeoxycholic acid;glycochenodeoxycholic aci;Glycine chenodeoxycholate;GLYCOCHENODEOXYCHOLIC ACID;Glycoanthropodeoxycholic acid;Glycochenodeoxycholic-d4 Acid
CBNumber: CB32130584
Molecular Formula: C26H43NO5
Formula Weight: 449.62
MOL File: 640-79-9.mol

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Glycochenodeoxycholic Acid Property

Boiling point:: 655.6±40.0 °C(Predicted)
Density: 1.162±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 29 mg/mL (64.50 mM)
form: Solid
pka: 3.58±0.10(Predicted)
color: White to off-white
InChI: InChI=1/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19?,20?,21-,24?,25+,26-/s3
InChIKey: GHCZAUBVMUEKKP-VHGKAQQHNA-N
SMILES: C(O)(=O)CNC(=O)CC[C@@H](C)[C@@H]1[C@]2(CCC3[C@]4(C)[C@]([H])(C[C@@H](O)C3C2CC1)C[C@H](O)CC4)C |&1:9,11,12,16,18,21,28,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

IsoSciences

Product number: 13104UNL
Product name: GlycochenodeoxycholicAcidSodiumSalt
Purity: ≥98%
Packaging: 10mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-6319
Product name: Glycochenodeoxycholicacid
Purity: >98.0%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

IsoSciences

Product number: 13108
Product name: GlycochenodeoxycholicAcid-[d9]
Purity: ≥97%
Packaging: 10mg
Price: $424
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0297043
Product name: GLYCOCHENODEOXYCHOLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $495.26
Updated: 2021/12/16

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Glycochenodeoxycholic Acid Chemical Properties,Usage,Production

Uses

Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC)[1][2][3][4].

Definition

ChEBI: A bile acid glycine conjugate having 3alpha,7alpha-dihydroxy-5beta-cholan-24-oyl as the bile acid component.

IC 50

Microbial Metabolite; Human Endogenous Metabolite

References

[1] Lan W, et al. Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells[J]. Toxicol Lett. 2020 Oct 1;331:11-21. DOI:10.1016/j.toxlet.2020.05.017
[2] Wang A, et al. Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts[J]. J Clin Exp Hepatol. 2017 Dec;7(4):316-320. DOI:10.1016/j.jceh.2017.04.002
[3] Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27. DOI:10.1023/a:1007021710825
[4] Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells[J]. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555. DOI:10.18632/aging.103751

Glycochenodeoxycholic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Glycochenodeoxycholic Acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Glycochenodeoxycholic Acid 640-79-9
Price: US $120.00-1200.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 200tons
Release date: 2025-08-19

Anhuyan (Hainan) Biotechnology Co., LTD

Product: Glycochenodeoxycholic Acid 640-79-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99.99
Supply Ability: 1000000
Release date: 2025-06-05

Shaanxi Xianhe Biotech Co., Ltd

Product: Glycinodeoxycholic acid 640-79-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-21

640-79-9, Glycochenodeoxycholic AcidRelated Search:

Glycochenodeoxycholic Acid 3-Sulfate DisodiuM Salt Glycochenodeoxycholic Acid-3-O-β-glucuronide Disodium Salt (3a,5b,7a)-24-[(carboxymethyl)amino]-7-hydroxy-24-oxocholan-3-yl b-D-glucopyranosiduronic acid Glycine methyl ester hydrochloride Glycochenodeoxycholic acid sodium salt TAUROCHENODEOXYCHOLIC ACID SODIUM SALT

GCDC

Glycoanthropodeoxycholic acid

Glycochenodeoxycholate

2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid

GLYCOCHENODEOXYCHOLIC ACID

N-[(3a,5b,7a)-3,7-dihydroxy-24-oxocholan-24-yl]-Glycine

Glycochenodeoxycholic acid, >98%

Chenodeoxycholylglycine

2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanoic acid

Glycochenodeoxycholic-d4 Acid

glycochenodeoxycholic acid (GCDCA)

3alpha,7alpha-Dihydroxy-N-(carboxymethyl)-5beta-cholan-24-amide

Glycine, N-[(3a,5b,7a)-3,7-dihydroxy-24-oxocholan-24-yl]

glycochenodeoxycholic aci

GCDCA

Glycine chenodeoxycholate

Glycine, N-[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl]-

2-((R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)acetic acid

Glycochenodeoxycholic acid (Chenodeoxycholylglycine)

Glycochenodeoxycholic Acid MaxSpec Standard

Ursodeoxycholic acid impurity 24

Glycine goose deoxycholic acid

2H9]-Glycochenodeoxycholic Acid

Glycinodeoxycholic acid

((R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)glycine

Glycochenodeoxycholic Acid-[d9] in Methanol

Glycochenodeoxycholic Acid, 10 mM in DMSO

Ganaminochenodeoxycholic acid

640-79-9