tert-butyl 3-aminopropanoate
- Product Name
- tert-butyl 3-aminopropanoate
- CAS No.
- 15231-41-1
- Chemical Name
- tert-butyl 3-aminopropanoate
- Synonyms
- Boc-C2-NH2;H-Beta-Ala-Otbu;tert-Butyl b-alaninate;6-Azetidinecarboxylicacid;b-Alanine tert-butyl ester;tert-butyl 3-aminopropanoate;β-Alanine,1,1-dimethylethylester;(5-phenylmethoxyoxan-5-yl)acetate;β-Alanine, 1,1-dimethylethyl ester;b-Alanine, 1,1-diMethylethyl ester
- CBNumber
- CB32134799
- Molecular Formula
- C7H15NO2
- Formula Weight
- 145.2
- MOL File
- 15231-41-1.mol
tert-butyl 3-aminopropanoate Property
- Boiling point:
- 192 ºC
- Density
- 0.959
- Flash point:
- 64 ºC
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 8.67±0.10(Predicted)
- form
- liquid
- color
- Colourless
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- B6504
- Product name
- tert-Butyl 3-Aminopropanoate
- Packaging
- 200MG
- Price
- $100
- Updated
- 2025/07/31
- Product number
- B6504
- Product name
- tert-Butyl 3-Aminopropanoate
- Packaging
- 1G
- Price
- $300
- Updated
- 2025/07/31
- Product number
- B699358
- Product name
- tert-Butyl3-Aminopropanoate
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 467116
- Product name
- tert-Butyl 3-Aminopropanoate
- Packaging
- 100mg
- Price
- $355
- Updated
- 2021/12/16
- Product number
- 208957
- Product name
- tert-Butyl 3-aminopropanoate
- Packaging
- 100mg
- Price
- $40
- Updated
- 2021/12/16
tert-butyl 3-aminopropanoate Chemical Properties,Usage,Production
Uses
tert-Butyl 3-Aminopropanoate is an intermediate useful in the synthesis of rac-3-Oxo Atorvastatin Sodium Salt (O847150), which is a byproduct impurity of Atorvastatin Calcium (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
Synthesis
1116-98-9
15231-41-1
The general procedure for the synthesis of tert-butyl 3-aminopropionate from tert-butyl cyanoacetate is as follows: 200 g of tert-butyl cyanoacetate was added to the reactor, followed by the addition of 1 kg of 2% methanol-ammonia aqueous solution and 20 g of Ruannei nickel. The reaction kettle was sealed and replaced three times with nitrogen and then three times with hydrogen. The hydrogen pressure was adjusted to 5 MPa, heated to 55 °C, and the reaction was carried out under stirring for 6 h, during which the hydrogen was continuously replenished. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to about 200 g and diluted with ethyl acetate. After cooling, the pH was adjusted to 3 with ethyl acetate-hydrogen chloride solution, the reaction system was concentrated again and the precipitated solid was dried to give 198 g of the target product tert-butyl 3-aminopropionate.
IC 50
Alkyl/ether
References
[1] Patent: CN105367435, 2016, A. Location in patent: Paragraph 0022; 0023
tert-butyl 3-aminopropanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-butyl 3-aminopropanoate manufacturers
- Product
- tert-butyl 3-aminopropanoate 15231-41-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- tert-butyl 3-aminopropanoate 15231-41-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30