5-Hydroxythionaphthene

Product Name: 5-Hydroxythionaphthene
CAS No.: 19301-35-0
Chemical Name: 5-Hydroxythionaphthene
Synonyms: 1-benzothiophen-5-ol;Benzo[b]thiophen-5-ol;Benzo[b]thiophene-5-ol;5-Hydroxythionaphthene
CBNumber: CB32186394
Molecular Formula: C8H6OS
Formula Weight: 150.2
MOL File: 19301-35-0.mol

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5-Hydroxythionaphthene Property

Melting point:: 103-104 °C
Boiling point:: 301.6±15.0 °C(Predicted)
Density: 1.347±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 9.43±0.40(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 3560CT
Product name: Benzo[b]thiophen-5-ol
Packaging: 100mg
Price: $155
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0391814
Product name: BENZO[B]THIOPHEN-5-OL
Purity: 95.00%
Packaging: 5MG
Price: $502.33
Updated: 2021/12/16

Matrix Scientific

Product number: 145105
Product name: Benzo[b]thiophen-5-ol
Purity: 95%
Packaging: 1g
Price: $1471
Updated: 2021/12/16

Matrix Scientific

Product number: 145105
Product name: Benzo[b]thiophen-5-ol
Purity: 95%
Packaging: 5g
Price: $4413
Updated: 2021/12/16

Chemenu

Product number: CM156720
Product name: Benzo[b]thiophen-5-ol
Purity: 95%+
Packaging: 1g
Price: $832
Updated: 2021/12/16

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5-Hydroxythionaphthene Chemical Properties,Usage,Production

Synthesis

20532-30-3

19301-35-0

Under nitrogen protection, 5-methoxybenzo[b]thiophene (Example 20a, 1.5 g, 9.14 mmol, 1.0 eq.) was dissolved in dichloromethane (20 mL) and cooled to -10 °C. Boron tribromide (1M in DCM, 36.6mL, 36.6mmol, 4.0 equiv) was added slowly and dropwise. The reaction was kept at this temperature and stirred for 30 minutes and then slowly warmed to room temperature to continue the reaction for 1 hour. After completion of the reaction, the reaction was quenched with methanol at -5 °C. Extraction was carried out with dichloromethane (50 mL) and water, the organic layer was washed with saturated aqueous sodium bisulfite, dried over anhydrous sodium sulfate and concentrated. The residue was purified by fast column chromatography (petroleum ether: ethyl acetate = 4:1) to afford the target product benzo[b]thiophen-5-ol (Example 20b, 1 g, 73% yield, yellow solid). Mass spectrometry analysis showed [M + 1] + = 151.0.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 8, p. 2948 - 2950
[2] Patent: WO2017/218960, 2017, A1. Location in patent: Paragraph 00463; 00466
[3] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 5, p. 1025 - 1030
[4] Journal of the American Chemical Society, 2013, vol. 135, # 20, p. 7450 - 7453
[5] Patent: US2010/279983, 2010, A1. Location in patent: Page/Page column 24

5-Hydroxythionaphthene Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Hydroxythionaphthene Suppliers

China 32 India 1 United States 3 Global 36

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19301-35-0