N-Boc-(4-piperidin-4-yl)butyric acid
- Product Name
- N-Boc-(4-piperidin-4-yl)butyric acid
- CAS No.
- 142247-38-9
- Chemical Name
- N-Boc-(4-piperidin-4-yl)butyric acid
- Synonyms
- N-Boc-4-piperidinebutanoic Acid;1-Boc-4-piperidinebutanoic acid;N-BOC-piperidine-4-butanoic acid;1-N-BOC-4-Piperidinebutanoic acid;N-BOC-4-PIPERIDIN-4-YL-BUTYRIC ACID;1-BOC-4-(3-CARBOXY-PROPYL)-PIPERIDINE;4-(1-BOC-PIPERIDIN-4-YL)-BUTANOIC ACID;4-(1-BOC-PIPERIDINE-4-YL)-BUTANOIC ACID;4-(1-tert-butoxycarbonyl-4-piperidyl)butanoic acid;4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)butanoic acid
- CBNumber
- CB3242560
- Molecular Formula
- C14H25NO4
- Formula Weight
- 271.35
- MOL File
- 142247-38-9.mol
N-Boc-(4-piperidin-4-yl)butyric acid Property
- Boiling point:
- 399.7±15.0 °C(Predicted)
- Density
- 1.085±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- pka
- 4.82±0.10(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B661978
- Product name
- N-Boc-4-Piperidin-4-yl-butyricAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB49970
- Product name
- 4-(1-Boc-piperidin-4-yl)butanoic acid
- Packaging
- 2g
- Price
- $89.9
- Updated
- 2021/12/16
- Product number
- 6943AA
- Product name
- 4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)butanoicacid
- Packaging
- 5g
- Price
- $164
- Updated
- 2021/12/16
- Product number
- 042383
- Product name
- 4-(1-Boc-piperidine-4-yl)-butanoic acid
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FB49970
- Product name
- 4-(1-Boc-piperidin-4-yl)butanoic acid
- Packaging
- 5G
- Price
- $240.3
- Updated
- 2021/12/16
N-Boc-(4-piperidin-4-yl)butyric acid Chemical Properties,Usage,Production
Chemical Properties
White powder
Synthesis
42516-28-9
79099-07-3
142247-38-9
Step A: Synthesis of 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)butanoic acid 1. tetraethyl-4-phosphonic acid crotonate (7.2 g, 28.8 mmol) was dissolved in 50 mL of anhydrous toluene and cooled to 0°C under nitrogen protection. 2. Potassium hexamethyldisilaminate (48 mL, 28.8 mmol, 0.5 M solution in toluene) was added slowly via syringe and stirred for 30 minutes. 3. Solid 1-tert-butoxycarbonyl-4-piperidone was added and the reaction mixture was gradually warmed to room temperature with continued stirring for 16 hours. 4. Upon completion of the reaction, the mixture was diluted with 300 mL of ethyl acetate, washed sequentially with saturated sodium chloride solution and dried over anhydrous sodium sulfate. 5. The solvent was removed by pressure-relief concentration and purified by fast column chromatography (150 g silica, 4/1 hexane/ethyl acetate) to give 327 mg (5% yield) of product as a mixture of isomers. Step B: Synthesis of N-Boc-4-piperidine butyric acid 1. the isomeric mixture obtained above (327 mg, 1.1 mmol) was dissolved with 10% palladium carbon (200 mg, 0.22 mmol) in 10 mL of methanol. 2. The reaction mixture was stirred using a hydrogen balloon for 2 hours under a 1 atm hydrogen atmosphere. 3. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated. 4. The residue was dissolved in 8 mL of mixed 1/1 tetrahydrofuran/water solvent, lithium hydroxide (96 mg, 4.4 mmol) was added and stirred overnight. 5. 50 ml of ethyl acetate and 50 ml of 1 M hydrochloric acid were added to separate the organic and aqueous layers. 6. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 291 mg (98% yield) of N-Boc-4-piperidine butyric acid.
References
[1] Patent: US6399619, 2002, B1
N-Boc-(4-piperidin-4-yl)butyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Boc-(4-piperidin-4-yl)butyric acid manufacturers
- Product
- N-Boc-(4-piperidin-4-yl)butyric acid 142247-38-9
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24