ChemicalBook > CAS DataBase List > N-Boc-(4-piperidin-4-yl)butyric acid

N-Boc-(4-piperidin-4-yl)butyric acid

Product Name: N-Boc-(4-piperidin-4-yl)butyric acid
CAS No.: 142247-38-9
Chemical Name: N-Boc-(4-piperidin-4-yl)butyric acid
Synonyms: N-Boc-4-piperidinebutanoic Acid;1-Boc-4-piperidinebutanoic acid;N-BOC-piperidine-4-butanoic acid;1-N-BOC-4-Piperidinebutanoic acid;N-BOC-4-PIPERIDIN-4-YL-BUTYRIC ACID;1-BOC-4-(3-CARBOXY-PROPYL)-PIPERIDINE;4-(1-BOC-PIPERIDIN-4-YL)-BUTANOIC ACID;4-(1-BOC-PIPERIDINE-4-YL)-BUTANOIC ACID;4-(1-tert-butoxycarbonyl-4-piperidyl)butanoic acid;4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)butanoic acid
CBNumber: CB3242560
Molecular Formula: C14H25NO4
Formula Weight: 271.35
MOL File: 142247-38-9.mol

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N-Boc-(4-piperidin-4-yl)butyric acid Property

Boiling point:: 399.7±15.0 °C(Predicted)
Density: 1.085±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 4.82±0.10(Predicted)
form: solid
Appearance: White to off-white Solid

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Safety

HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: B661978
Product name: N-Boc-4-Piperidin-4-yl-butyricAcid
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB49970
Product name: 4-(1-Boc-piperidin-4-yl)butanoic acid
Packaging: 2g
Price: $89.9
Updated: 2021/12/16

AK Scientific

Product number: 6943AA
Product name: 4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)butanoicacid
Packaging: 5g
Price: $164
Updated: 2021/12/16

Matrix Scientific

Product number: 042383
Product name: 4-(1-Boc-piperidine-4-yl)-butanoic acid
Packaging: 1g
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB49970
Product name: 4-(1-Boc-piperidin-4-yl)butanoic acid
Packaging: 5G
Price: $240.3
Updated: 2021/12/16

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N-Boc-(4-piperidin-4-yl)butyric acid Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

42516-28-9

79099-07-3

142247-38-9

Step A: Synthesis of 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)butanoic acid 1. tetraethyl-4-phosphonic acid crotonate (7.2 g, 28.8 mmol) was dissolved in 50 mL of anhydrous toluene and cooled to 0°C under nitrogen protection. 2. Potassium hexamethyldisilaminate (48 mL, 28.8 mmol, 0.5 M solution in toluene) was added slowly via syringe and stirred for 30 minutes. 3. Solid 1-tert-butoxycarbonyl-4-piperidone was added and the reaction mixture was gradually warmed to room temperature with continued stirring for 16 hours. 4. Upon completion of the reaction, the mixture was diluted with 300 mL of ethyl acetate, washed sequentially with saturated sodium chloride solution and dried over anhydrous sodium sulfate. 5. The solvent was removed by pressure-relief concentration and purified by fast column chromatography (150 g silica, 4/1 hexane/ethyl acetate) to give 327 mg (5% yield) of product as a mixture of isomers. Step B: Synthesis of N-Boc-4-piperidine butyric acid 1. the isomeric mixture obtained above (327 mg, 1.1 mmol) was dissolved with 10% palladium carbon (200 mg, 0.22 mmol) in 10 mL of methanol. 2. The reaction mixture was stirred using a hydrogen balloon for 2 hours under a 1 atm hydrogen atmosphere. 3. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated. 4. The residue was dissolved in 8 mL of mixed 1/1 tetrahydrofuran/water solvent, lithium hydroxide (96 mg, 4.4 mmol) was added and stirred overnight. 5. 50 ml of ethyl acetate and 50 ml of 1 M hydrochloric acid were added to separate the organic and aqueous layers. 6. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 291 mg (98% yield) of N-Boc-4-piperidine butyric acid.

References

[1] Patent: US6399619, 2002, B1

N-Boc-(4-piperidin-4-yl)butyric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Boc-(4-piperidin-4-yl)butyric acid manufacturers

Career Henan Chemical Co

Product: N-Boc-(4-piperidin-4-yl)butyric acid 142247-38-9
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

142247-38-9, N-Boc-(4-piperidin-4-yl)butyric acidRelated Search:

4-Aminobutyric acid Haloperidol Butyric Acid Indole-3-butyric acid Hydrocortisone-17-butyrate Diphenoxylate (R)-1-BOC-4-(3-CBZ-AMINO-3-METHOXYCARBONYL-PROPYL)PIPERIDINE 3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECANE-9-CARBOXYLIC ACID TERT-BUTYL 4-(3-(ETHOXYCARBONYL)-2-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE N-Boc-(4-piperidin-4-yl)butyric acid α-Carbonyl phenybutyric acid 3-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)CYCLOHEXANECARBOXYLIC ACID (SR)-N-ALPHA-N'-BIS-(T-BUTYLOXYCARBONYL)-4-PIPERIDINYL-3-AMINO-BUTANOIC ACID, RACEMIC BOC-L-HOMO[ALA-4-PIP(N-BOC)] 3-TERT-BUTYL 9-ETHYL 3-AZASPIRO[5.5]UNDECANE-3,9-DICARBOXYLATE 4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-ACETIC ACID (S)-A-FMOC-G-BOC-4-HOMO-PIPERIDYLALANINE FMOC-D, L-HOMO[ALA-4-PIP(N-BOC)]

N-BOC-4-PIPERIDIN-4-YL-BUTYRIC ACID

4-Piperidinebutanoic acid, 1-[(1,1-diMethylethoxy)carbonyl]-

1-BOC-4-(3-CARBOXY-PROPYL)-PIPERIDINE

4-(1-BOC-PIPERIDIN-4-YL)-BUTANOIC ACID

4-(3-CARBOXY-PROPYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(1-BOC-PIPERIDINE-4-YL)-BUTANOIC ACID

1-Boc-4-piperidinebutanoic acid

N-Boc-4-piperidinebutanoic Acid

4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)butanoic acid

N-BOC-piperidine-4-butanoic acid

4-(1-tert-butoxycarbonyl-4-piperidyl)butanoic acid

1-[(1,1-Dimethylethoxy)carbonyl]-4-piperidinebutanoic acid

4-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]butanoic acid

1-N-BOC-4-Piperidinebutanoic acid

142247-38-9