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TRIMIDOX

Product Name
TRIMIDOX
CAS No.
95933-74-7
Chemical Name
TRIMIDOX
Synonyms
VF 233;TRIMIDOX;Trimidox Exclusive;MSLJYSGFUMYUDX-UHFFFAOYSA-N;N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE;Benzenecarboximidamide, N,3,4,5-tetrahydroxy-;4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one
CBNumber
CB32446894
Molecular Formula
C7H8N2O4
Formula Weight
184.15
MOL File
95933-74-7.mol
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TRIMIDOX Property

storage temp. 
Store at -20°C
solubility 
≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form 
crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10009083
Product name
Trimidox
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
10009083
Product name
Trimidox
Purity
≥98%
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
10009083
Product name
Trimidox
Purity
≥98%
Packaging
50mg
Price
$477
Updated
2024/03/01
Cayman Chemical
Product number
10009083
Product name
Trimidox
Purity
≥98%
Packaging
100mg
Price
$834
Updated
2024/03/01
TRC
Product number
T799013
Product name
Trimidox
Packaging
10mg
Price
$145
Updated
2021/12/16
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TRIMIDOX Chemical Properties,Usage,Production

Description

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 μM.

Uses

Trimidox is a specific ribonucleotide reductase inhibitor.

Definition

ChEBI: Trimidox is a benzenetriol.

References

[1] szekeres t, fritzer m, strobl h, et al. synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia hl-60 cells[j]. blood, 1994, 84(12): 4316-4321.
[2] elledge s j, zhou z, allen j b. ribonucleotide reductase: regulation, regulation, regulation[j]. trends in biochemical sciences, 1992, 17(3): 119-123.

TRIMIDOX Preparation Products And Raw materials

Raw materials

Preparation Products

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TRIMIDOX Suppliers

ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8141
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
8740
Advantage
58

95933-74-7, TRIMIDOXRelated Search:


  • TRIMIDOX
  • VF 233
  • Trimidox Exclusive
  • MSLJYSGFUMYUDX-UHFFFAOYSA-N
  • 4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one
  • Benzenecarboximidamide, N,3,4,5-tetrahydroxy-
  • N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE
  • 95933-74-7