TRIMIDOX

Product Name: TRIMIDOX
CAS No.: 95933-74-7
Chemical Name: TRIMIDOX
Synonyms: VF 233;TRIMIDOX;Trimidox Exclusive;MSLJYSGFUMYUDX-UHFFFAOYSA-N;N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE;Benzenecarboximidamide, N,3,4,5-tetrahydroxy-;4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one
CBNumber: CB32446894
Molecular Formula: C7H8N2O4
Formula Weight: 184.15
MOL File: 95933-74-7.mol

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TRIMIDOX Property

storage temp.: Store at -20°C
solubility: ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10009083
Product name: Trimidox
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 10009083
Product name: Trimidox
Purity: ≥98%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 10009083
Product name: Trimidox
Purity: ≥98%
Packaging: 50mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 10009083
Product name: Trimidox
Purity: ≥98%
Packaging: 100mg
Price: $834
Updated: 2024/03/01

TRC

Product number: T799013
Product name: Trimidox
Packaging: 10mg
Price: $145
Updated: 2021/12/16

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TRIMIDOX Chemical Properties,Usage,Production

Description

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ value of 35 μM.

Uses

Trimidox is a specific ribonucleotide reductase inhibitor.

Definition

ChEBI: Trimidox is a benzenetriol.

References

[1] szekeres t, fritzer m, strobl h, et al. synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia hl-60 cells[j]. blood, 1994, 84(12): 4316-4321.
[2] elledge s j, zhou z, allen j b. ribonucleotide reductase: regulation, regulation, regulation[j]. trends in biochemical sciences, 1992, 17(3): 119-123.

TRIMIDOX Preparation Products And Raw materials

Raw materials

Preparation Products

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TRIMIDOX Suppliers

CHINA 11 India 2 United States 3 Global 16

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Energy Chemical

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Shanghai Yifei Biotechnology Co. , Ltd.

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Shenzhen Xinbosheng Biological Technology Co., Ltd.

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Beijing Shengke Boyuan Biotechnology Co., Ltd.

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Shanghai Ziqi Biological Technology Co., Ltd.

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Morning Student Science and Technology (Guangzhou) Co., Ltd.

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Beijing Dongge Boye Biotechnology Co., Ltd.

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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95933-74-7, TRIMIDOXRelated Search:

TRIMIDOX N-HYDROXY-3,4,5-TRIMETHOXY-BENZAMIDINE 4,N-DIHYDROXY-BENZAMIDINE

TRIMIDOX

VF 233

Trimidox Exclusive

MSLJYSGFUMYUDX-UHFFFAOYSA-N

4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one

Benzenecarboximidamide, N,3,4,5-tetrahydroxy-

N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE

95933-74-7