ChemicalBook > CAS DataBase List > 1-N-Cbz-belta-Proline

1-N-Cbz-belta-Proline

Product Name: 1-N-Cbz-belta-Proline
CAS No.: 188527-21-1
Chemical Name: 1-N-Cbz-belta-Proline
Synonyms: C67154;1-N-CBZ-BETA-PROLINE;1-N-CBZ-BELTA-PROLINE;3-CARBOXY-1-CBZ-PYRROLIDINE;1-Cbz-pyrrolidine-3-carbo...;1-(Benzyloxycarbonyl)pyrrolidi;N-Cbz-3-pyrrolidinecarboxylicacid;1-Cbz-3-pyrrolidinecarboxylic acid;1-Cbz-pyrrolidine-3-carboxylic acid;N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
CBNumber: CB3244726
Molecular Formula: C13H15NO4
Formula Weight: 249.26
MOL File: 188527-21-1.mol

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1-N-Cbz-belta-Proline Property

Boiling point:: 432.3±45.0 °C(Predicted)
Density: 1.309±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 4.46±0.20(Predicted)
form: Solid
Appearance: White to off-white Solid
CAS DataBase Reference: 188527-21-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B287195
Product name: 1-(Benzyloxycarbonyl)pyrrolidine-3-carboxylicAcid
Packaging: 100mg
Price: $50
Updated: 2021/12/16

TRC

Product number: B287195
Product name: 1-(Benzyloxycarbonyl)pyrrolidine-3-carboxylicAcid
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142975
Product name: 1-((Benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid
Packaging: 1g
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-WH
Product name: 1-[(Benzyloxy)carbonyl]pyrrolidine-3-carboxylic acid
Purity: 97.0%
Packaging: 250mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: W4063
Product name: 1-N-CBZ-PYRROLIDINE-3-CARBOXYLICACID
Packaging: 1g
Price: $88
Updated: 2021/12/16

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1-N-Cbz-belta-Proline Chemical Properties,Usage,Production

Uses

1-?(Benzyloxycarbonyl)?pyrrolidine-?3-?carboxylic Acid is a reagent used in the synthesis of cyclin-dependent kinase 4-inhibitors (CDK4) for cancer treatments. Also used towards the discovery of a potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer pased upon benzimidazole carboxamide moieties.

Synthesis

188847-00-9

188527-21-1

To a 250 mL multi-necked round-bottomed flask was added 8.1 g (30.8 mmol) of 1-benzyl 3-methylpyrrolidine-1,3-dicarboxylate and 80 mL of tetrahydrofuran, and 80 mL of an aqueous solution of lithium hydroxide of 3.9 g (92.4 mmol) was added slowly dropwise.The reaction mixture was stirred for 1 hr at 0 °C, followed by stirring at room temperature overnight. Upon completion of the reaction, the mixture was washed with ether and the pH of the mixture was adjusted to 5-6 with 0.5 M hydrochloric acid. the mixture was extracted three times with 30 mL of ethyl acetate, and the organic phases were combined. The organic phase was dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give 7.3 g of 1-Cbz-3-pyrrolidinecarboxylic acid as a yellow oil in 95% yield.

References

[1] Patent: CN104817549, 2017, B. Location in patent: Paragraph 0044-0046

1-N-Cbz-belta-Proline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-N-Cbz-belta-Proline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID 188527-21-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

188527-21-1, 1-N-Cbz-belta-ProlineRelated Search:

1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID (S)-N-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID 3-Pyrrolidinecarboxylic acid (R )-1-Cbz-pyrrolidine-3-carboxylic acid,(R)-1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID 1-N-CBZ-4-HYDROXY-BETA-PROLINE TRANS-4-N-BOC-AMINO-1-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER TRANS-4-AMINO-1-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID 3-Boc-amino-1-Cbz-pyrrolidine-3-carboxylic acid (S)-1-Cbz-pyrrolidine-3-carboxylic acid 1-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER R-1-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER 1-Cbz-3-pyrrolidine carboxylic Acid Methyl Ester 4-(3-CHLORO-PHENYL)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 4-PHENYL-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 4-(4-METHOXY-PHENYL)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 4-(2-CHLORO-PHENYL)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 4-(4-CHLORO-PHENYL)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER

1-N-CBZ-BETA-PROLINE

1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID

3-CARBOXY-1-CBZ-PYRROLIDINE

PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER

N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID

1-Cbz-3-pyrrolidinecarboxylic acid

1-Cbz-pyrrolidine-3-carboxylic acid

C67154

1-(benzyloxycarbonyl)pyrrolidine-3-carboxylic acid

1-Cbz-pyrrolidine-3-carbo...

1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester

N-Cbz-DL-3-Pyrrolidinecarboxylic acid

1-(Benzyloxycarbonyl)pyrrolidine-3-carboxylicacid,97%

1-phenylmethoxycarbonylpyrrolidine-3-carboxylic acid

1-(Benzyloxycarbonyl)pyrrolidi

1-(Phenylmethyl) 1,3-pyrrolidinedicarboxylate

N-Cbz-3-pyrrolidinecarboxylicacid

1-N-CBZ-BELTA-PROLINE

1-N-Cbz-pyrrolidine-3-carboxylic acid, CAS 188527-21-1

1-(Benzyl) 1,3-pyrrolidinedicarboxylate

188527-21-1

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