4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE
- Product Name
- 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE
- CAS No.
- 1801-06-5
- Chemical Name
- 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE
- Synonyms
- Capecitabine Impurity 35;4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE;2-Methoxy-4-chloro-5-fluoropyrimidine;PyriMidine, 4-chloro-5-fluoro-2-Methoxy-;2-Chloro-5-fluoro-2-methoxypyrimidine 95%;4-Chloro-5-fluoro-2-methoxypyrimidine (Capecitabine Impurity)
- CBNumber
- CB32451074
- Molecular Formula
- C5H4ClFN2O
- Formula Weight
- 162.55
- MOL File
- 1801-06-5.mol
4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE Property
- Boiling point:
- 86-87 °C(Press: 21 Torr)
- Density
- 1.400±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO
- pka
- -1.34±0.29(Predicted)
- form
- Oil
- color
- Colourless
- Stability:
- Moisture Sensitive
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C368948
- Product name
- 4-Chloro-5-fluoro-2-methoxypyrimidine
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- C368948
- Product name
- 4-Chloro-5-fluoro-2-methoxypyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC201178
- Product name
- 4-Chloro-5-fluoro-2-methoxypyrimidine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $64
- Updated
- 2021/12/16
- Product number
- J96346
- Product name
- 4-Chloro-5-fluoro-2-methoxypyrimidine
- Packaging
- 5g
- Price
- $470
- Updated
- 2021/12/16
- Product number
- PC201178
- Product name
- 4-Chloro-5-fluoro-2-methoxypyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $158
- Updated
- 2021/12/16
4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE Chemical Properties,Usage,Production
Synthesis
1480-96-2
1801-06-5
General procedure for the synthesis of 2-methoxy-4-chloro-5-fluoropyrimidine from 2-methoxy-5-fluorouracil: 14.4 g of 2-methoxy-5-fluorouracil (compound IV) was dissolved in 29 mL of toluene and 15.2 g of triethylamine was added as a base. The reaction mixture was heated to 50-80 °C and 18.4 g of trichlorophosphorus was slowly added dropwise. After the dropwise addition, the temperature was maintained and the reaction was continued with stirring for 5-7 hours. After completion of the reaction, the mixture was cooled to room temperature and quenched by addition of water. The organic and aqueous phases were separated and the organic phase was collected. The organic phase was concentrated under reduced pressure to remove the solvent to afford 15.4 g of 2-methoxy-4-chloro-5-fluoropyrimidine (Compound III, straw-colored liquid) in 95.0% molar yield and 95.8% HPLC purity.
References
[1] Patent: CN105272922, 2016, A. Location in patent: Paragraph 0035; 0036; 0037
[2] Patent: WO2006/72831, 2006, A1. Location in patent: Page/Page column 66
4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE manufacturers
- Product
- 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE 1801-06-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-09