ChemicalBook > CAS DataBase List > 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE

4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE

Product Name
4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE
CAS No.
1801-06-5
Chemical Name
4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE
Synonyms
Capecitabine Impurity 35;4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE;2-Methoxy-4-chloro-5-fluoropyrimidine;PyriMidine, 4-chloro-5-fluoro-2-Methoxy-;2-Chloro-5-fluoro-2-methoxypyrimidine 95%;4-Chloro-5-fluoro-2-methoxypyrimidine (Capecitabine Impurity)
CBNumber
CB32451074
Molecular Formula
C5H4ClFN2O
Formula Weight
162.55
MOL File
1801-06-5.mol
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4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE Property

Boiling point:
86-87 °C(Press: 21 Torr)
Density 
1.400±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO
pka
-1.34±0.29(Predicted)
form 
Oil
color 
Colourless
Stability:
Moisture Sensitive
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368948
Product name
4-Chloro-5-fluoro-2-methoxypyrimidine
Packaging
500mg
Price
$140
Updated
2021/12/16
TRC
Product number
C368948
Product name
4-Chloro-5-fluoro-2-methoxypyrimidine
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC201178
Product name
4-Chloro-5-fluoro-2-methoxypyrimidine
Purity
97%
Packaging
250mg
Price
$64
Updated
2021/12/16
AK Scientific
Product number
J96346
Product name
4-Chloro-5-fluoro-2-methoxypyrimidine
Packaging
5g
Price
$470
Updated
2021/12/16
Apolloscientific
Product number
PC201178
Product name
4-Chloro-5-fluoro-2-methoxypyrimidine
Purity
97%
Packaging
1g
Price
$158
Updated
2021/12/16
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4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

1480-96-2

1801-06-5

General procedure for the synthesis of 2-methoxy-4-chloro-5-fluoropyrimidine from 2-methoxy-5-fluorouracil: 14.4 g of 2-methoxy-5-fluorouracil (compound IV) was dissolved in 29 mL of toluene and 15.2 g of triethylamine was added as a base. The reaction mixture was heated to 50-80 °C and 18.4 g of trichlorophosphorus was slowly added dropwise. After the dropwise addition, the temperature was maintained and the reaction was continued with stirring for 5-7 hours. After completion of the reaction, the mixture was cooled to room temperature and quenched by addition of water. The organic and aqueous phases were separated and the organic phase was collected. The organic phase was concentrated under reduced pressure to remove the solvent to afford 15.4 g of 2-methoxy-4-chloro-5-fluoropyrimidine (Compound III, straw-colored liquid) in 95.0% molar yield and 95.8% HPLC purity.

References

[1] Patent: CN105272922, 2016, A. Location in patent: Paragraph 0035; 0036; 0037
[2] Patent: WO2006/72831, 2006, A1. Location in patent: Page/Page column 66

4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE manufacturers

Career Henan Chemical Co
Product
4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE 1801-06-5
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-09

1801-06-5, 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINERelated Search:

4-CHLORO-2-ETHOXY-5-FLUOROPYRIMIDINE Pyrimidine, 4-chloro-5-fluoro- (9CI) Pyrimidine, 4-chloro-2-methoxy- (9CI) 5-FLUORO-2-HYDROXYPYRIMIDINE 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE

  • 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE
  • PyriMidine, 4-chloro-5-fluoro-2-Methoxy-
  • 2-Methoxy-4-chloro-5-fluoropyrimidine
  • 4-Chloro-5-fluoro-2-methoxypyrimidine (Capecitabine Impurity)
  • Capecitabine Impurity 35
  • 2-Chloro-5-fluoro-2-methoxypyrimidine 95%
  • 1801-06-5