4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 343306-50-3
- Chemical Name
- 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 1-Boc-4-(3-ForMyl-4-hydroxyphenyl)piperazine;tert-Butyl 4-(3-forMyl-4-hydroxyphenyl)piperazine-1-carboxylate;4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperazinecarboxylic acid, 4-(3-formyl-4-hydroxyphenyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB32452798
- Molecular Formula
- C16H22N2O4
- Formula Weight
- 306.36
- MOL File
- 343306-50-3.mol
4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 463.4±45.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 10.42±0.35(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 9787DA
- Product name
- Tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate
- Packaging
- 250mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- CHM0380626
- Product name
- 1-BOC-4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.3
- Updated
- 2021/12/16
- Product number
- CM125004
- Product name
- tert-butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $832
- Updated
- 2021/12/16
- Product number
- A254583
- Product name
- tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $857
- Updated
- 2021/12/16
- Product number
- CD11139817
- Product name
- tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $881
- Updated
- 2021/12/16
4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
1761-61-1
57260-71-6
343306-50-3
General procedure: 5-bromo-2-hydroxybenzaldehyde (1000 g, 4.97 mol, 1 eq.) and tert-butyl 1-piperazinecarboxylate (1065.4 g, 5.72 mol, 1.1 eq.) were added to a reactor protected by nitrogen and palladium acetate (11.0 g, 0.049 mol, 0.01 eq.) and tri-tert-butylphosphine (10.0 g, 0.049 mol, 0.01 equiv) to a solution of toluene (0.3 L). Sodium tert-butoxide (1052.4 g, 10.9 mol, 2.2 eq.) was subsequently added. The reaction mixture was stirred at 42 °C for 22 h to form a reddish brown slurry. Upon completion of the reaction, a mixture of distilled water (8 L) and glacial acetic acid (800 mL) was added (pH adjusted to 5-6) and stirred for 10 min. The organic phase was separated and washed twice with distilled water (2 x 8L). The organic phase was dried by adding sodium sulfate (2.5 kg), stirred for 30 min and filtered. The dark orange organic phase was weighed (9.65 kg) and an aliquot (100 g) was concentrated under vacuum to give a dark orange oil. The oily substance was purified by column chromatography (silica gel, height: 30 cm, diameter: 4 cm, eluent: methyl tert-butyl ether/heptane 1:1) to afford the target compound tert-butyl 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate as yellow crystals (8.9 g). The total yield was 56% based on an aliquot. Mass spectrum (ES+): 307 (M+H).
References
[1] Patent: EP2110374, 2009, A1. Location in patent: Page/Page column 30
[2] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 18, p. 4843 - 4852
4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers
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