1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE

Product Name: 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE
CAS No.: 158985-25-2
Chemical Name: 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE
Synonyms: 1-Boc-4-(4-Hydroxy-P;4-(4-Boc-1-piperazinyl)phenol;N-Boc-4-(4-hydroxyphenyl)piperazine;1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE;4-(4-Hydroxyphenyl)piperazine, N1-Boc protected;tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate;4-(4-hydroxyphenyl)-1-piperazinecarboxylic acid tert-butyl ester;1-(4-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(4-HYDROXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperazinecarboxylic acid, 4-(4-hydroxyphenyl)-, 1,1-dimethylethyl ester
CBNumber: CB9260054
Molecular Formula: C15H22N2O3
Formula Weight: 278.35
MOL File: 158985-25-2.mol

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1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE Property

Boiling point:: 436.0±40.0 °C(Predicted)
Density: 1.167±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.18±0.30(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C15H22N2O3/c1-15(2,3)20-14(19)17-10-8-16(9-11-17)12-4-6-13(18)7-5-12/h4-7,18H,8-11H2,1-3H3
InChIKey: YEHWSWXESXPBOS-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(O)C=C2)CC1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AstaTech

Product number: 56642
Product name: N-BOC-4-(4-HYDROXYPHENYL)PIPERAZINE
Purity: 97%
Packaging: 1G
Price: $30
Updated: 2026/04/30

AstaTech

Product number: 56642
Product name: N-BOC-4-(4-HYDROXYPHENYL)PIPERAZINE
Purity: 97%
Packaging: 5G
Price: $78
Updated: 2026/04/30

AstaTech

Product number: 56642
Product name: N-BOC-4-(4-HYDROXYPHENYL)PIPERAZINE
Purity: 97%
Packaging: 25G
Price: $230
Updated: 2026/04/30

TRC

Product number: B810273
Product name: tert-Butyl4-(4-Hydroxyphenyl)piperazine-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B810273
Product name: tert-Butyl4-(4-Hydroxyphenyl)piperazine-1-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

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1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE Chemical Properties,Usage,Production

Synthesis

56621-48-8

24424-99-5

158985-25-2

To a solution of 4-(1-piperazinyl)phenol (2.0 g, 11.22 mmol) in water (56 mL) was added sodium hydroxide (673 mg, 16.83 mmol) followed by di-tert-butyl dicarbonate (2.7 g, 12.34 mmol). The reaction mixture was stirred at room temperature overnight. On the next day, the reaction mixture was filtered and tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate was collected as a brown solid (3.1 g, 99% yield), which was washed with water (50 mL) and used for the next reaction without further purification.1H NMR (300 MHz, DMSO-d6): δ 6.79 (AA'BB', 2H, JAB = 9.1 Hz. JAA' = 2.4 Hz), 6.66 (AA'BB', 2H, JAB = 9.1 Hz, JBB' = 2.4 Hz), 3.43 (dd, 4H, J = 5.3,4.9 Hz), 2.88 (dd, 4H, J = 5.2,5.1 Hz), 1.41 (s, 9H); 13C NMR (75.5 MHz, DMSO-d6 ): δ153.8,151.4,144.0,118.5,115.4,78.8,50.3,28.0.

References

[1] Patent: WO2008/83056, 2008, A2. Location in patent: Page/Page column 51
[2] European Journal of Organic Chemistry, 2009, # 25, p. 4290 - 4299
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 5, p. 1035 - 1049
[4] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 2, p. 215 - 220
[5] Patent: WO2017/93491, 2017, A1. Location in patent: Page/Page column 3; 12

1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE Suppliers

China 50 India 2 United Kingdom 2 United States 14 Global 68

Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd

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parabiochem

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View Lastest Price from 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE manufacturers

Career Henan Chemical Co

Product: 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE 158985-25-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-14

158985-25-2, 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINERelated Search:

1-BOC-4-(2-HYDROXY-PHENYL)-PIPERAZINE 1-BOC-4-(3-HYDROXY-PHENYL)-PIPERAZINE TERT-BUTYL 4-(4-METHOXY-2,3-DIMETHYLPHENYL)PIPERAZINE-1-CARBOXYLATE CIVENTICHEM CV-4046 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE TERT-BUTYL 4-(4-HYDROXY-2,3-DIMETHYLPHENYL)PIPERAZINE-1-CARBOXYLATE 1-Piperidinecarboxylic acid, 4-(6-chloro-2-pyridinyl)-, 1,1-dimethylethyl ester tert-butyl 4-(6-aMinopyridin-3-yl)piperidine-1-carboxylate 4-(4-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Piperazinecarboxylic acid, 4-(4-piperidinylmethyl)-, 1,1-dimethylethyl ester tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

4-(4-HYDROXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-(4-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE

4-(4-Hydroxyphenyl)piperazine, N1-Boc protected

4-(4-hydroxyphenyl)-1-piperazinecarboxylic acid tert-butyl ester

N-Boc-4-(4-hydroxyphenyl)piperazine

tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate

1-Boc-4-(4-Hydroxy-P

1-Piperazinecarboxylic acid, 4-(4-hydroxyphenyl)-, 1,1-dimethylethyl ester

4-(4-Boc-1-piperazinyl)phenol

158985-25-2

pharmacetical