ChemicalBook > CAS DataBase List > 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE

1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE

Product Name
1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE
CAS No.
158985-25-2
Chemical Name
1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE
Synonyms
1-Boc-4-(4-Hydroxy-P;4-(4-Boc-1-piperazinyl)phenol;N-Boc-4-(4-hydroxyphenyl)piperazine;1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE;4-(4-Hydroxyphenyl)piperazine, N1-Boc protected;tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate;4-(4-hydroxyphenyl)-1-piperazinecarboxylic acid tert-butyl ester;1-(4-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(4-HYDROXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperazinecarboxylic acid, 4-(4-hydroxyphenyl)-, 1,1-dimethylethyl ester
CBNumber
CB9260054
Molecular Formula
C15H22N2O3
Formula Weight
278.35
MOL File
158985-25-2.mol
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1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE Property

Boiling point:
436.0±40.0 °C(Predicted)
Density 
1.167±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.18±0.30(Predicted)
Appearance
Light brown to brown Solid
InChI
InChI=1S/C15H22N2O3/c1-15(2,3)20-14(19)17-10-8-16(9-11-17)12-4-6-13(18)7-5-12/h4-7,18H,8-11H2,1-3H3
InChIKey
YEHWSWXESXPBOS-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(O)C=C2)CC1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B810273
Product name
tert-Butyl4-(4-Hydroxyphenyl)piperazine-1-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
B810273
Product name
tert-Butyl4-(4-Hydroxyphenyl)piperazine-1-carboxylate
Packaging
50mg
Price
$60
Updated
2021/12/16
Chem-Impex
Product number
17899
Product name
1-Boc-4-(4-hydroxyphenyl)piperazine,98%(HPLC)
Purity
98%(HPLC)
Packaging
1G
Price
$75.38
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB51151
Product name
1-Boc-4-(4-hydroxyphenyl)piperazine
Packaging
1g
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB51151
Product name
1-Boc-4-(4-hydroxyphenyl)piperazine
Packaging
2g
Price
$84
Updated
2021/12/16
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1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE Chemical Properties,Usage,Production

Synthesis

56621-48-8

24424-99-5

158985-25-2

To a solution of 4-(1-piperazinyl)phenol (2.0 g, 11.22 mmol) in water (56 mL) was added sodium hydroxide (673 mg, 16.83 mmol) followed by di-tert-butyl dicarbonate (2.7 g, 12.34 mmol). The reaction mixture was stirred at room temperature overnight. On the next day, the reaction mixture was filtered and tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate was collected as a brown solid (3.1 g, 99% yield), which was washed with water (50 mL) and used for the next reaction without further purification.1H NMR (300 MHz, DMSO-d6): δ 6.79 (AA'BB', 2H, JAB = 9.1 Hz. JAA' = 2.4 Hz), 6.66 (AA'BB', 2H, JAB = 9.1 Hz, JBB' = 2.4 Hz), 3.43 (dd, 4H, J = 5.3,4.9 Hz), 2.88 (dd, 4H, J = 5.2,5.1 Hz), 1.41 (s, 9H); 13C NMR (75.5 MHz, DMSO-d6 ): δ153.8,151.4,144.0,118.5,115.4,78.8,50.3,28.0.

References

[1] Patent: WO2008/83056, 2008, A2. Location in patent: Page/Page column 51
[2] European Journal of Organic Chemistry, 2009, # 25, p. 4290 - 4299
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 5, p. 1035 - 1049
[4] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 2, p. 215 - 220
[5] Patent: WO2017/93491, 2017, A1. Location in patent: Page/Page column 3; 12

1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE manufacturers

Career Henan Chemical Co
Product
1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE 158985-25-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-14

158985-25-2, 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINERelated Search:

1-BOC-4-(2-HYDROXY-PHENYL)-PIPERAZINE 1-BOC-4-(3-HYDROXY-PHENYL)-PIPERAZINE TERT-BUTYL 4-(4-METHOXY-2,3-DIMETHYLPHENYL)PIPERAZINE-1-CARBOXYLATE CIVENTICHEM CV-4046 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE TERT-BUTYL 4-(4-HYDROXY-2,3-DIMETHYLPHENYL)PIPERAZINE-1-CARBOXYLATE 1-Piperidinecarboxylic acid, 4-(6-chloro-2-pyridinyl)-, 1,1-dimethylethyl ester tert-butyl 4-(6-aMinopyridin-3-yl)piperidine-1-carboxylate 4-(4-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Piperazinecarboxylic acid, 4-(4-piperidinylmethyl)-, 1,1-dimethylethyl ester tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

  • 4-(4-HYDROXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 1-(4-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE
  • 4-(4-Hydroxyphenyl)piperazine, N1-Boc protected
  • 4-(4-hydroxyphenyl)-1-piperazinecarboxylic acid tert-butyl ester
  • N-Boc-4-(4-hydroxyphenyl)piperazine
  • tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate
  • 1-Boc-4-(4-Hydroxy-P
  • 1-Piperazinecarboxylic acid, 4-(4-hydroxyphenyl)-, 1,1-dimethylethyl ester
  • 4-(4-Boc-1-piperazinyl)phenol
  • 158985-25-2
  • pharmacetical