ChemicalBook > CAS DataBase List > 1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE

Product Name
1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
CAS No.
866396-34-1
Chemical Name
1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
Synonyms
DPPI 1C HCL;DPPI 1C HYDROCHLORIDE;Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem;2,5-Pyrrolidinedicarbonitrile, 1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]acetyl]-, (2R,5S)-rel-;1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
CBNumber
CB32453447
Molecular Formula
C14H20N4O2
Formula Weight
276.33
MOL File
866396-34-1.mol
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1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Property

storage temp. 
Desiccate at RT
solubility 
Soluble in DMSO > 10 mM
form 
White solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
317641
Product name
Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem
Packaging
5mg
Price
$294
Updated
2023/01/07
Tocris
Product number
2783
Product name
DPPI1chydrochloride
Purity
≥98%(HPLC)
Packaging
1
Price
$116
Updated
2021/12/16
Tocris
Product number
2783
Product name
DPPI1chydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$248
Updated
2021/12/16
Usbiological
Product number
255195
Product name
DPPI 1c hydrochloride
Packaging
1mg
Price
$360
Updated
2021/12/16
ApexBio Technology
Product number
A4425
Product name
DPPI1chydrochloride
Packaging
10mg
Price
$380
Updated
2021/12/16
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1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Chemical Properties,Usage,Production

General Description

An orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 μM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.

Biological Activity

Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC 50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC 50 > 30 μ M). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Suppliers

China 13 United Kingdom 1 United States 6 Global 20
Tocris Bioscience
Tel
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Fax
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Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

866396-34-1, 1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDERelated Search:

(S)-Pyrrolidine-2-carbonitrile hydrochloride (S)-PYRROLIDINE-2-CARBONITRILE (R)-PYRROLIDINE-2-CARBONITRILE HYDROCHLORIDE 1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE

  • 1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
  • DPPI 1C HYDROCHLORIDE
  • DPPI 1C HCL
  • Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem
  • 2,5-Pyrrolidinedicarbonitrile, 1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]acetyl]-, (2R,5S)-rel-
  • 866396-34-1
  • C14H20N4O2HCl