TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE

Product Name: TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE
CAS No.: 152537-03-6
Chemical Name: TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE
Synonyms: 1-Boc-3-(hydroxyethyl)aze...;N-Boc-2-(azetidin-3-yl)ethanol;1-Boc-3-(hydroxyethyl)azetidine;1-Boc-3-(2-hydroxyethyl)azetidine;(2E)-3-(5-methyl-13-furyl)acrylic acid;tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxyl;TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE;3-(2-hydroxyethyl)-1-azetidinecarboxylic acid tert-butyl ester;tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate - [B0298];1-Azetidinecarboxylic acid, 3-(2-hydroxyethyl)-, 1,1-dimethy...
CBNumber: CB32454772
Molecular Formula: C10H19NO3
Formula Weight: 201.26
MOL File: 152537-03-6.mol

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TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE Property

Boiling point:: 287.4±13.0 °C(Predicted)
Density: 1.092±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 15.05±0.10(Predicted)
form: oil
color: Yellow
InChI: InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-8(7-11)4-5-12/h8,12H,4-7H2,1-3H3
InChIKey: PIEFOIGZJZFQQJ-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(CCO)C1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B810060
Product name: tert-Butyl3-(2-Hydroxyethyl)azetidine-1-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B810060
Product name: tert-Butyl3-(2-Hydroxyethyl)azetidine-1-carboxylate
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: Y7610
Product name: tert-Butyl3-(2-hydroxyethyl)azetidine-1-carboxylate
Packaging: 1g
Price: $211
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-PJ
Product name: 1-Boc-3-(hydroxyethyl)azetidine
Packaging: 250mg
Price: $125
Updated: 2021/12/16

Matrix Scientific

Product number: 068634
Product name: tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate
Purity: >95%
Packaging: 250mg
Price: $341
Updated: 2021/12/16

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TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

183062-96-6

152537-03-6

General procedure for the synthesis of tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate from N-Boc-3-azetidineacetic acid: 2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid (3.91 g) was dissolved in tetrahydrofuran (THF, 18.17 mL), and the solution was cooled to 0 °C. The solution was then purified by stirring. Under stirring, ethylborane (1 M solution of THF, 54.5 mL) was added slowly and dropwise. The reaction mixture was stirred at 0 °C for 1 hour. Subsequently, water was added slowly and dropwise to quench the unreacted borane. The reaction mixture was diluted with ethyl acetate (EtOAc, 150 mL) and washed with deionized water (100 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate as a clear oil in 100% yield. The product was confirmed by 1H NMR (CDCl3): δ 4.0 (t, 2H), 3.60 (m, 4H), 2.65 (m, 1H), 1.85 (m, 2H), 1.43 (s, 9H).

References

[1] Patent: WO2011/86125, 2011, A1. Location in patent: Page/Page column 61
[2] Patent: WO2010/141809, 2010, A1. Location in patent: Page/Page column 33
[3] Patent: WO2017/27684, 2017, A1. Location in patent: Paragraph 00148; 00254
[4] Patent: WO2018/140809, 2018, A1. Location in patent: Paragraph 00454

TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE Suppliers

China 72 India 1 United Kingdom 1 United States 6 Global 80

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

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Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Synthonix Inc

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Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Combi-Blocks Inc.

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Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

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Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Matrix Scientific

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Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

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View Lastest Price from TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE manufacturers

Honest Joy Holdings Limited

Product: tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate 152537-03-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-02-08

Career Henan Chemical Co

Product: TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE 152537-03-6
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-03-23

152537-03-6, TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATERelated Search:

N-Boc-3-azetidine acetic acid (S)-3-(AMINO-METHOXYCARBONYL-METHYL)-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HCL FMOC-S-AZETGLY(BOC)-OH (S)-3-(AMINO-CARBOXY-METHYL)-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-A-CBZ-(3-N-BOC-AZETIDINYL) GLYCINE TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE

TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE

1-Boc-3-(hydroxyethyl)azetidine

1-Boc-3-(hydroxyethyl)aze...

1-Azetidinecarboxylic acid, 3-(2-hydroxyethyl)-, 1,1-diMethylethyl ester

N-Boc-2-(azetidin-3-yl)ethanol

1-Boc-3-(2-hydroxyethyl)azetidine

3-(2-Hydroxy-ethyl)-azetidine-1-carboxylic acid tert-butyl ester

3-(2-hydroxyethyl)-1-azetidinecarboxylic acid tert-butyl ester

1-Azetidinecarboxylic acid, 3-(2-hydroxyethyl)-, 1,1-dimethy...

(2E)-3-(5-methyl-13-furyl)acrylic acid

tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxyl

tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate - [B0298]

152537-03-6