ChemicalBook > CAS DataBase List > 3-BOC-AMINO-PYRROLIDIN-2-ONE

3-BOC-AMINO-PYRROLIDIN-2-ONE

Product Name
3-BOC-AMINO-PYRROLIDIN-2-ONE
CAS No.
99780-97-9
Chemical Name
3-BOC-AMINO-PYRROLIDIN-2-ONE
Synonyms
3-BOC-AMINO-PYRROLIDIN-2-ONE;tert-Butyl (2-oxopyrrolidin-3-yl);tert-butyl N-(2-oxopyrrolidin-3-yl)carbamate;Carbamic acid, N-(2-oxo-3-pyrrolidinyl)-, 1,1-dimethylethyl ester
CBNumber
CB32455108
Molecular Formula
C9H16N2O3
Formula Weight
200.23
MOL File
99780-97-9.mol
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3-BOC-AMINO-PYRROLIDIN-2-ONE Property

Boiling point:
394.0±31.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
11.05±0.20(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

AK Scientific
Product number
Z6019
Product name
3-Boc-amino-pyrrlidin-2-one
Packaging
1g
Price
$331
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0095957
Product name
3-BOC-AMINO-PYRROLIDIN-2-ONE
Purity
95.00%
Packaging
5MG
Price
$495.19
Updated
2021/12/16
Matrix Scientific
Product number
132798
Product name
tert-Butyl2-oxopyrrolidin-3-ylcarbamate
Purity
97%
Packaging
1g
Price
$933
Updated
2021/12/16
Matrix Scientific
Product number
132798
Product name
tert-Butyl2-oxopyrrolidin-3-ylcarbamate
Purity
97%
Packaging
5g
Price
$3214
Updated
2021/12/16
Chemenu
Product number
CM119024
Product name
3-(Boc-amino)pyrrolidin-2-one
Purity
97%
Packaging
10g
Price
$1543
Updated
2021/12/16
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3-BOC-AMINO-PYRROLIDIN-2-ONE Chemical Properties,Usage,Production

Synthesis

24424-99-5

2483-65-0

99780-97-9

To a mixed methanol and triethylamine solution (9:1, 130 mL, v/v) of 3-aminopyrrolidin-2-one (39) (2.8 g, 28 mmol), di-tert-butyl dicarbonate (6.7 g, 30.8 mmol) was added. The reaction mixture was stirred overnight at room temperature and then heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting solid was collected by filtration and washed with ether to afford 3-(Boc-amino)pyrrolidin-2-one in 97% yield.

References

[1] Patent: US2005/165065, 2005, A1. Location in patent: Page/Page column 24
[2] Patent: WO2017/75056, 2017, A1. Location in patent: Paragraph 0371
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 2, p. 251 - 260
[4] Patent: US6441017, 2002, B1

3-BOC-AMINO-PYRROLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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99780-97-9, 3-BOC-AMINO-PYRROLIDIN-2-ONERelated Search:

(S)-(3-N-BOC-AMINO-2-OXO-PYRROLIDIN-1-YL)-ACETIC ACID RARECHEM EM WB 0257 2-(3-(TERT-BUTOXYCARBONYLAMINO)-2-OXOPYRROLIDIN-1-YL)ACETICACID 3-BOC-AMINO-PYRROLIDIN-2-ONE (R)-3-(BOC-AMINO)-2-OXO-1-PYRROLIDINE-ACETIC ACID (S)-BOC-3-AMINO-2-PYRROLIDINONE

  • 3-BOC-AMINO-PYRROLIDIN-2-ONE
  • Carbamic acid, N-(2-oxo-3-pyrrolidinyl)-, 1,1-dimethylethyl ester
  • tert-Butyl (2-oxopyrrolidin-3-yl)
  • tert-butyl N-(2-oxopyrrolidin-3-yl)carbamate
  • 99780-97-9