5-FLUORO-6-METHOXY-3-PYRIDINECARBOXYLIC ACID
- Product Name
- 5-FLUORO-6-METHOXY-3-PYRIDINECARBOXYLIC ACID
- CAS No.
- 953780-42-2
- Chemical Name
- 5-FLUORO-6-METHOXY-3-PYRIDINECARBOXYLIC ACID
- Synonyms
- 5-fluoro-6-methoxynicotinic acid;3-Fluoro-2-methoxy-5-pyridinecarboxylic acid;5-FLUORO-6-METHOXY-3-PYRIDINECARBOXYLIC ACID;5-Fluoro-6-methoxypyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 5-fluoro-6-methoxy-
- CBNumber
- CB32455274
- Molecular Formula
- C7H6FNO3
- Formula Weight
- 171.13
- MOL File
- 953780-42-2.mol
5-FLUORO-6-METHOXY-3-PYRIDINECARBOXYLIC ACID Property
- Boiling point:
- 275.9±35.0 °C(Predicted)
- Density
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 3.40±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
N-Bromosuccinimide Price
- Product number
- F402545
- Product name
- 5-Fluoro-6-methoxynicotinicAcid
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- Z5403
- Product name
- 5-Fluoro-6-methoxynicotinicacid
- Packaging
- 250mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 126647
- Product name
- 5-Fluoro-6-methoxynicotinicacid
- Purity
- >95%
- Packaging
- 1g
- Price
- $810
- Updated
- 2021/12/16
- Product number
- HCH0361408
- Product name
- 5-FLUORO-6-METHOXYNICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.26
- Updated
- 2021/12/16
- Product number
- CM177630
- Product name
- 5-Fluoro-6-methoxynicotinicacid
- Purity
- 95%
- Packaging
- 10g
- Price
- $585
- Updated
- 2021/12/16
5-FLUORO-6-METHOXY-3-PYRIDINECARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
953780-40-0
953780-42-2
General procedure for the synthesis of 5-fluoro-6-methoxynicotinic acid from 5-fluoro-6-methoxynicotinic acid methyl ester: 5-fluoro-6-methoxynicotinic acid methyl ester (3.5 g, 18.9 mmol) and potassium hydroxide (4.2 g, 61.5 mmol) were dissolved in methanol (70 ml), and the reaction was stirred at room temperature for 5 hours. After completion of the reaction, methanol was removed by concentration under reduced pressure, the residue was dissolved in water and the aqueous solution was washed with ether. Subsequently, the aqueous phase was acidified to pH=1 with dilute hydrochloric acid and extracted with ether. The organic layers were combined, washed with saturated brine, dried with anhydrous sodium sulfate, and finally concentrated under reduced pressure to give 5-fluoro-6-methoxynicotinic acid (3.2 g, 98% yield) as a white solid.
References
[1] Patent: WO2007/120729, 2007, A2. Location in patent: Page/Page column 57
[2] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00667; 00674; 00675
5-FLUORO-6-METHOXY-3-PYRIDINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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