4-(1,3-THIAZOL-2-YL)BENZALDEHYDE

Uses

Product Name: 4-(1,3-THIAZOL-2-YL)BENZALDEHYDE
CAS No.: 198904-53-9
Chemical Name: 4-(1,3-THIAZOL-2-YL)BENZALDEHYDE
Synonyms: 4-(2-thiazolyl)benzaldehyde;4-THIAZOL-2-YL-BENZALDEHYDE;Benzaldehyde, 4-(2-thiazolyl)-;4-(1,3-THIAZOL-2-YL)BENZALDEHYDE;4-THIAZOL-2-YL-BENZALDEHYDE, 95+%;4-(5-Nitrothiazol-2-yl)benzaldehyde;2-(4-Formylphenyl)thiazole-5-carboxylic acid;2-(4-Formylphenyl)thiazole-4-carboxylic acid
CBNumber: CB3245879
Molecular Formula: C10H7NOS
Formula Weight: 189.23
MOL File: 198904-53-9.mol

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4-(1,3-THIAZOL-2-YL)BENZALDEHYDE Property

Boiling point:: 350.3±44.0 °C(Predicted)
Density: 1.269±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.69±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

TRC

Product number: T344698
Product name: 4-Thiazol-2-yl-benzaldehyde
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T344698
Product name: 4-Thiazol-2-yl-benzaldehyde
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: T344698
Product name: 4-Thiazol-2-yl-benzaldehyde
Packaging: 500mg
Price: $110
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003033
Product name: 4-THIAZOL-2-YL-BENZALDEHYDE
Purity: 95.00%
Packaging: 250MG
Price: $181.65
Updated: 2021/12/16

Matrix Scientific

Product number: 071870
Product name: 4-Thiazol-2-yl-benzaldehyde
Purity: 95+%
Packaging: 1g
Price: $185
Updated: 2021/12/16

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4-(1,3-THIAZOL-2-YL)BENZALDEHYDE Chemical Properties,Usage,Production

Uses

4-(1,3-Thiazol-2-yl)benzaldehyde is an organic intermediate that can be obtained by the Suzuki reaction of 2-bromothiazole with 4-carboxyphenylboronic acid, or by reacting 4-bromobenzaldehyde dimethyl acetal with 2-bromothiazole after preparing a Grignard reagent.

Synthesis

3034-53-5

87199-17-5

198904-53-9

The general procedure for the synthesis of 4-(1,3-thiazol-2-yl)benzaldehyde from 2-bromothiazole (0.9 mL, 10 mmol) and 4-formylbenzeneboronic acid (1.65 g, 11 mmol) was as follows:(1) Under argon protection, a 2-bromothiazole, 4-formylbenzeneboronic acid, sodium carbonate (2.65 g, 25 mmol), toluene (150 mL), ethanol (30 mL) and water (30 mL) mixture was stirred at room temperature for 30 minutes. (2) Tetrakis(triphenylphosphine)palladium(0) (0.58 mg, 0.5 mmol) was added to the reaction system and the reaction was heated under reflux conditions for 15 hours. (3) After completion of the reaction, the reaction mixture was cooled, poured into water and extracted with ethyl acetate. (4) The organic phases were combined, washed sequentially with water and brine, and then dried with anhydrous magnesium sulfate. (5) The organic phase was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography, and finally recrystallized with a mixed solvent of ethyl acetate/hexane to obtain the target product 4-(2-thiazolyl)benzaldehyde (1.4 g, 74% yield). The product was analyzed by elemental analysis (C10H7NOS) and showed the following: melting point 91.5-92.5 °C; calculated values: C, 63.47; H, 3.73; N, 7.40; measured values: C, 63.67; H, 3.60; N, 7.31. 1H-NMR (CDCl3) δ: 7.46 (1H, d, J = 3.2 Hz), 7.95-7.99 ( 3H, m).

References

[1] Patent: EP1123918, 2001, A1
[2] Patent: US2003/220272, 2003, A1
[3] Patent: US2013/217663, 2013, A1. Location in patent: Paragraph 0240

4-(1,3-THIAZOL-2-YL)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(1,3-THIAZOL-2-YL)BENZALDEHYDE Suppliers

Belgium 1 China 62 India 1 United Kingdom 5 United States 10 Global 79

J & K SCIENTIFIC LTD.

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Cool Pharm, Ltd

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198904-53-9, 4-(1,3-THIAZOL-2-YL)BENZALDEHYDERelated Search:

3-THIAZOL-2-YL-BENZALDEHYDE,3-(1,3-THIAZOL-2-YL)BENZALDEHYDE 2-THIAZOL-2-YL-BENZALDEHYDE, 95+%,2-(1,3-Thiazol-2-yl)benzaldehyde,2-THIAZOL-2-YL-BENZALDEHYDE 4-[4-(TERT-BUTYL)-1,3-THIAZOL-2-YL]BENZALDEHYDE,4-(4-(TERT-BUTYL)THIAZOL-2-YL)BENZALDEHYDE METHYL 4-[4-(4-FLUOROPHENYL)-1,3-THIAZOL-2-YL]BENZENECARBOXYLATE 4-(2-METHYL-1,3-THIAZOL-4-YL)BENZALDEHYDE 3-(2-Methyl-1,3-thiazol-4yl)benzaldehyde 97+%,3-(2-METHYL-1,3-THIAZOL-4YL)BENZALDEHYDE,3-(2-METHYL-THIAZOL-4-YL)-BENZALDEHYDE N-(2,4-DIFLUOROPHENYL)-4-(4-PHENYL-1,3-THIAZOL-2-YL)BENZENECARBOXAMIDE N-PHENYL-4-(4-PHENYL-1,3-THIAZOL-2-YL)BENZENECARBOXAMIDE 4-[4-(2,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENECARBOXAMIDE N-METHYL-4-(4-PHENYL-1,3-THIAZOL-2-YL)BENZENECARBOXAMIDE 4-(4-PHENYL-1,3-THIAZOL-2-YL)BENZENECARBOXYLIC ACID 4-[4-(2,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]BENZENECARBOXYLIC ACID N-(3,4-DICHLOROPHENYL)-4-(4-PHENYL-1,3-THIAZOL-2-YL)BENZENECARBOXAMIDE 4-[4-(2,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]-N-(2,4-DIFLUOROPHENYL)BENZENECARBOXAMIDE N-(4-CHLOROPHENYL)-4-(4-PHENYL-1,3-THIAZOL-2-YL)BENZENECARBOXAMIDE METHYL 4-(4-PHENYL-1,3-THIAZOL-2-YL)BENZENECARBOXYLATE METHYL 4-[4-(2,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]BENZENECARBOXYLATE 4-[4-(4-FLUOROPHENYL)-1,3-THIAZOL-2-YL]BENZENECARBOXYLIC ACID

4-(2-thiazolyl)benzaldehyde

4-(1,3-THIAZOL-2-YL)BENZALDEHYDE

4-THIAZOL-2-YL-BENZALDEHYDE

2-(4-Formylphenyl)thiazole-4-carboxylic acid

2-(4-Formylphenyl)thiazole-5-carboxylic acid

4-(5-Nitrothiazol-2-yl)benzaldehyde

4-THIAZOL-2-YL-BENZALDEHYDE, 95+%

Benzaldehyde, 4-(2-thiazolyl)-

198904-53-9

Aldehydes

Phenyls & Phenyl-Het