4-(HYDROXYMETHYL)PHENYL PIVALATE
- Product Name
- 4-(HYDROXYMETHYL)PHENYL PIVALATE
- CAS No.
- 59012-91-8
- Chemical Name
- 4-(HYDROXYMETHYL)PHENYL PIVALATE
- Synonyms
- 4-(HydroxyMethyl)phenol pivalate;4-(HYDROXYMETHYL)PHENYL PIVALATE;Propanoic acid, 2,2-dimethyl-, 4-(hydroxymethyl)phenyl ester
- CBNumber
- CB32459737
- Molecular Formula
- C12H16O3
- Formula Weight
- 208.25
- MOL File
- 59012-91-8.mol
4-(HYDROXYMETHYL)PHENYL PIVALATE Property
- storage temp.
- Sealed in dry,Room Temperature
N-Bromosuccinimide Price
- Product number
- CHM0390055
- Product name
- 4-(HYDROXYMETHYL)PHENYL PIVALATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.4
- Updated
- 2021/12/16
- Product number
- 8773AB
- Product name
- 4-(Hydroxymethyl)phenylpivalate
- Packaging
- 100mg
- Price
- $273
- Updated
- 2021/12/16
- Product number
- 59012918
- Product name
- 4-(Hydroxymethyl)phenylpivalate
- Packaging
- 250mg
- Price
- $279.84
- Updated
- 2021/12/16
- Product number
- CD12057922
- Product name
- 4-(Hydroxymethyl)phenylpivalate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $653
- Updated
- 2021/12/16
- Product number
- 59012918
- Product name
- 4-(Hydroxymethyl)phenylpivalate
- Packaging
- 1g
- Price
- $693
- Updated
- 2021/12/16
4-(HYDROXYMETHYL)PHENYL PIVALATE Chemical Properties,Usage,Production
Synthesis
623-05-2
3282-30-2
59012-91-8
Procedure for the synthesis of 4-(hydroxymethyl)phenyl trimethyl acetate (Compound M1): to a stirred solution of 4-hydroxybenzyl alcohol (6.21 g, 50 mmol) in anhydrous THF (50 mL) was added triethylamine (10.43 mL, 75 mmol) under the protection of argon, followed by a slow dropwise addition of pivaloyl chloride (6.79 mL, 55 mmol) at room temperature. The reaction mixture was continued to be stirred at room temperature for 60 minutes. Upon completion of the reaction, the reaction was quenched by the addition of water (0.2 mL) and the mixture was allowed to stand overnight. Subsequently, the reaction mixture was diluted with EtOAc (~400 mL) and washed sequentially with saturated NaHCO3 solution (3 x 100 mL) and brine (100 mL). The organic phase was dried with Na2SO4, filtered and concentrated. The product was purified by rapid chromatography on a silica gel column (4 × 20 cm) (TLC conditions: Rf = 0.4, unfolding agent was ethyl acetate/hexane (4:6)), and ethyl acetate/hexane (4:6) was used as eluent. The fractions containing the pure product were combined, concentrated and dried under vacuum to give 7.75 g (74% yield) of the target compound in the form of a colorless oil.1H NMR (DMSO-d6): δ 7.35 (d, 2H, J = 8.6 Hz), 7.04 (d, 2H, J = 8.6 Hz), 5.22 (t, 1H), 4.50 (d, 2H), 1.31 (s, 9H).
References
[1] Journal of Organic Chemistry, 2005, vol. 70, # 23, p. 9470 - 9479
[2] Journal of Organic Chemistry, 2006, vol. 71, # 22, p. 8651 - 8654
[3] Chemical Communications, 2018, vol. 54, # 61, p. 8466 - 8469
[4] Patent: WO2015/153496, 2015, A1. Location in patent: Paragraph 00201
[5] Patent: WO2015/153510, 2015, A1. Location in patent: Paragraph 00201
4-(HYDROXYMETHYL)PHENYL PIVALATE Preparation Products And Raw materials
Raw materials
Preparation Products
4-(HYDROXYMETHYL)PHENYL PIVALATE Suppliers
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View Lastest Price from 4-(HYDROXYMETHYL)PHENYL PIVALATE manufacturers
- Product
- 4-(HYDROXYMETHYL)PHENYL PIVALATE 59012-91-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-09