3-(3-METHOXYPHENYL)PROPIONIC ACID
- Product Name
- 3-(3-METHOXYPHENYL)PROPIONIC ACID
- CAS No.
- 10516-71-9
- Chemical Name
- 3-(3-METHOXYPHENYL)PROPIONIC ACID
- Synonyms
- 3-(3-METHOXYPHENYL)PROPANOIC ACID;3-Methoxybenzenepropanoic acid;3-METHOXYHYDROCINNAMIC ACID;KML-79;KML-111;M-METHOXYHYDROCINNAMIC ACID;3-Methoxybenzenepropionic acid;3-(3-Methoxphenyl)propionicacid;3-Methoxy-β-phenylpropionic acid;3-(M-METHOXYPHENYL)PROPIONIC ACID
- CBNumber
- CB3246306
- Molecular Formula
- C10H12O3
- Formula Weight
- 180.2
- MOL File
- 10516-71-9.mol
3-(3-METHOXYPHENYL)PROPIONIC ACID Property
- Melting point:
- 43-45 °C (lit.)
- Boiling point:
- 318.1±17.0 °C(Predicted)
- Density
- 1.144±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO
- pka
- pK1:4.654 (25°C)
- form
- Solid
- color
- White to light yellow
- Water Solubility
- Soluble in water.
- BRN
- 1874422
- InChI
- InChI=1S/C10H12O3/c1-13-9-4-2-3-8(7-9)5-6-10(11)12/h2-4,7H,5-6H2,1H3,(H,11,12)
- InChIKey
- BJJQJLOZWBZEGA-UHFFFAOYSA-N
- SMILES
- C1(CCC(O)=O)=CC=CC(OC)=C1
- CAS DataBase Reference
- 10516-71-9(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 349763
- Product name
- 3-(3-Methoxyphenyl)propionic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $29.33
- Updated
- 2025/07/31
- Product number
- 349763
- Product name
- 3-(3-Methoxyphenyl)propionic acid
- Purity
- 99%
- Packaging
- 25g
- Price
- $139.3
- Updated
- 2025/07/31
- Product number
- M329433
- Product name
- 3-(3-Methoxyphenyl)propionic acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- M329433
- Product name
- 3-(3-Methoxyphenyl)propionic acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- F254
- Product name
- 3-(3-Methoxyphenyl)propionic acid
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
3-(3-METHOXYPHENYL)PROPIONIC ACID Chemical Properties,Usage,Production
Chemical Properties
Brown, low melting solid
Uses
3-(3-Methoxyphenyl)propionic acid is used as pharmaceutical intermediates.
Definition
ChEBI: 3-Methoxybenzenepropanoic acid is a member of methoxybenzenes.
General Description
3-(3-Methoxyphenyl)propionic acid can be prepared by the catalytic (palladium on charcoal) reduction of its corresponding unsaturated acid with H2.
Synthesis
6099-04-3
10516-71-9
3-Methoxycinnamic acid (8) (3.56 g, 19.98 mmol) was dissolved in methanol (100 mL) and 10% Pd/C catalyst (0.44 g) was added. The mixture was stirred in a hydrogen (balloon) atmosphere for 12 h at room temperature. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth (Celite) and the diatomaceous earth was washed with ethyl acetate (3 x 30 mL). The filtrates were combined and the ethyl acetate and methanol were removed by evaporation under reduced pressure to give 3-(3-methoxyphenyl)propionic acid (10) (3.59 g, 19.7 mmol, quantitative yield). The product was characterized by 1H NMR (CDCl3, 600 MHz) and 13C NMR (CDCl3, 150 MHz) with the following data: 1H NMR δ 11.93 (1H, s), 7.27 (1H, t, J = 7.5 Hz), 6.88 (2H, m), 6.83 (1H, d, J = 8 Hz), 3.79 (3H, s), 3.79 (3H, s) 2.99 (2H, t, J = 7 Hz), 2.73 (2H, t, J = 7 Hz); 13C NMR δ 179.2, 159.9, 142.0, 129.6, 120.7, 114.2, 111.6, 54.9, 35.5, 30.6.
References
[1] MedChemComm, 2016, vol. 7, # 12, p. 2418 - 2427
[2] Patent: US2018/2355, 2018, A1. Location in patent: Paragraph 0094
[3] Journal of Organic Chemistry, 1992, vol. 57, # 4, p. 1262 - 1271
[4] Journal of Organic Chemistry, 1996, vol. 61, # 26, p. 9146 - 9155
[5] Tetrahedron Asymmetry, 2014, vol. 25, # 6-7, p. 578 - 582
3-(3-METHOXYPHENYL)PROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(3-METHOXYPHENYL)PROPIONIC ACID manufacturers
- Product
- 3-(3-METHOXYPHENYL)PROPIONIC ACID 10516-71-9
- Price
- US $31.00-1.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-10
- Product
- 3-(3-METHOXYPHENYL)PROPIONIC ACID 10516-71-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 3-(3-METHOXYPHENYL)PROPIONIC ACID 10516-71-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09