3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
- Product Name
- 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
- CAS No.
- 1135-23-5
- Chemical Name
- 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
- Synonyms
- 3-(4-HYDROXY-3-METHOXYPHENYL)PROPANOIC ACID;HYDROFERULIC ACID;Shorbic Acid;Dihydroconiferylic Acid;HYDROFERULIC ACID(RG);3-Methoxyphloretic Acid;Ferulic Acid Impurity 1;3-(4-HYDROXYMETHYL)PROPIONIC ACID;Dihydroferulic acid, 10 mM in DMSO;Pyridoxal 5'-phosphate hydrate(1:x)
- CBNumber
- CB7665965
- Molecular Formula
- C10H12O4
- Formula Weight
- 196.2
- MOL File
- 1135-23-5.mol
3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Property
- Melting point:
- 87-93 °C
- Boiling point:
- 120-130 °C(Press: 0.5 Torr)
- Density
- 1.259±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in dimethyl sulfoxide and methanol.
- pka
- 4.73±0.10(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- BRN
- 2110370
- InChI
- InChI=1S/C10H12O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2,4,6,11H,3,5H2,1H3,(H,12,13)
- InChIKey
- BOLQJTPHPSDZHR-UHFFFAOYSA-N
- SMILES
- C1(CCC(O)=O)=CC=C(O)C(OC)=C1
- LogP
- 0.810 (est)
- CAS DataBase Reference
- 1135-23-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 2
- HazardClass
- IRRITANT
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17803
- Product name
- 3-(4-Hydroxy-3-methoxyphenyl)propionic acid
- Purity
- ≥96.0% (T)
- Packaging
- 5g
- Price
- $219
- Updated
- 2025/07/31
- Product number
- H1180
- Product name
- 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- H1180
- Product name
- 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $199
- Updated
- 2025/07/31
- Product number
- D448900
- Product name
- DihydroFerulicAcid
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 057093
- Product name
- 3-(4-Hydroxy-3-methoxyphenyl)propionic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Chemical Properties,Usage,Production
Uses
3-(4-Hydroxy-3-methoxyphenyl)propionic acid (hydroferulic acid) was used to inhibit prostaglandin E(2) production.
Uses
A caffeine metabolite which showed high antioxidant activity. It is a very sensitive biomarker for the consumption of relatively small amount of coffee.
Definition
ChEBI: A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 3 has been replaced by a 4-hydroxy-3-methoxyphenyl group.
Synthesis
1135-24-6
1135-23-5
The general procedure for the synthesis of isopropyl phosphate (mono- and di-ester mixtures) from 3-methoxy-4-hydroxyphenylacrylic acid was as follows: to a stirred suspension of ferulic acid (25 g, 128.74 mmol) in methanol (200 ml) was added Pd/C catalyst (3.75 g). The reaction mixture was subjected to hydrogenation under hydrogen pressure of 1.2 MPa for 4 h at 50°C. Upon completion of the reaction, the mixture was cooled to room temperature, the catalyst was removed by filtration, and a white solid product (25 g, 99% yield) was obtained by concentration under reduced pressure. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and ESI-MS: 1H NMR δ 6.76 (d, J = 7.8 Hz, 1H), 6.62 (m, 2H), 3.79 (s, 3H), 2.81 (t, J = 7.7 Hz, 2H), 2.58 (t, J = 7.7 Hz, 2H); ESI-MS m /z: 195.1 [M-H]?
in vivo
Assessing the influence of an 11 weeks intervention with a resistant starch-enriched whole grain diet (HI-RS-WG, 25% RS) compared to a WG control diet (LOW-RS-WG, 6.9% RS) on serum profile of polyphenols (PPs) in 20 Zucker Diabetic Fatty rats. Five PPs were identified and quantified in serum samples of rats belonging to both intervention groups. HI-RS-WG rats had 2.6 folds higher serum concentrations of total PPs than LOW-RS-WG rats. An explorative data reduction approach, based on the Principal Component Analysis identified two principal components related to the gut microbiota fermentation and food intake, respectively. Results showed that the abundance of hippuric acid and Dihydroferulic acid in HI-RS-WG rats was explained by the stronger gut microbiota fermentation in those rats than in LOW-RS-WG rats[4].
References
[1] Advanced Synthesis and Catalysis, 2013, vol. 355, # 1, p. 81 - 86
[2] Tetrahedron Letters, 2010, vol. 51, # 44, p. 5753 - 5756
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 13, p. 4462 - 4466
[4] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 429 - 439
[5] Journal of the American Chemical Society, 2017, vol. 139, # 10, p. 3767 - 3773
3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID manufacturers
- Product
- 3-(4-Hydroxy-3-Methoxyphenyl)propionic acid 135-23-5
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50 tons
- Release date
- 2020-01-20
- Product
- 3-(4-Hydroxy-3-Methoxyphenyl)Propionic Acid 1135-23-5
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-05-25