2,4-DICHLORO-5-FLUOROQUINAZOLINE
- Product Name
- 2,4-DICHLORO-5-FLUOROQUINAZOLINE
- CAS No.
- 87611-00-5
- Chemical Name
- 2,4-DICHLORO-5-FLUOROQUINAZOLINE
- Synonyms
- 4-dichloro-5-fluoroquinazoline;2,4-DICHLORO-5-FLUOROQUINAZOLINE;Quinazoline, 2,4-dichloro-5-fluoro-
- CBNumber
- CB32464689
- Molecular Formula
- C8H3Cl2FN2
- Formula Weight
- 217.03
- MOL File
- 87611-00-5.mol
2,4-DICHLORO-5-FLUOROQUINAZOLINE Property
- Boiling point:
- 277.3±22.0 °C(Predicted)
- Density
- 1.571±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.91±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C8H3Cl2FN2/c9-7-6-4(11)2-1-3-5(6)12-8(10)13-7/h1-3H
- InChIKey
- AXMYGHKVWFFYCR-UHFFFAOYSA-N
- SMILES
- N1=C2C(C(F)=CC=C2)=C(Cl)N=C1Cl
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 118763
- Product name
- 2,4-Dichloro-5-fluoroquinazoline
- Purity
- >97%
- Packaging
- 1g
- Price
- $348
- Updated
- 2021/12/16
- Product number
- 118763
- Product name
- 2,4-Dichloro-5-fluoroquinazoline
- Purity
- >97%
- Packaging
- 500mg
- Price
- $258
- Updated
- 2021/12/16
- Product number
- 3902AC
- Product name
- 2,4-Dichloro-5-fluoroquinazoline
- Packaging
- 10g
- Price
- $992
- Updated
- 2021/12/16
- Product number
- HCH0316442
- Product name
- 2,4-DICHLORO-5-FLUOROQUINAZOLINE
- Purity
- 98.00%
- Packaging
- 1G
- Price
- $1443.75
- Updated
- 2021/12/16
- Product number
- A105726
- Product name
- 2,4-Dichloro-5-fluoroquinazoline
- Purity
- 97%
- Packaging
- 25g
- Price
- $1453
- Updated
- 2021/12/16
2,4-DICHLORO-5-FLUOROQUINAZOLINE Chemical Properties,Usage,Production
Synthesis
192570-33-5
87611-00-5
5-Fluoroquinazoline-2,4(1H,3H)-dione (B-1, 2.6 g, 14.43 mmol) was used as starting material and suspended in 29 mL of toluene and heated to 50 °C. Subsequently, phosphoryl chloride (9.88 mL, 108.25 mmol) was slowly added dropwise, followed by DBU (4.31 mL, 28.87 mmol). The reaction mixture was stirred vigorously at 120 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by slow dropwise addition to ice water. The aqueous layer was extracted with ethyl acetate, the organic phase was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with toluene as eluent to give 2,4-dichloro-5-fluoroquinazoline (B-2, 3.41 g, 80.8% yield) as white powder. The product could be used directly in the subsequent reaction without further purification.
References
[1] Patent: WO2017/109722, 2017, A1. Location in patent: Paragraph 0449
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2297 - 2300
2,4-DICHLORO-5-FLUOROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DICHLORO-5-FLUOROQUINAZOLINE manufacturers
- Product
- 2,4-DICHLORO-5-FLUOROQUINAZOLINE 87611-00-5
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg; 10kg; 25kg
- Release date
- 2020-01-07