4-CHLORO-5-FLUOROQUINAZOLINE

Product Name: 4-CHLORO-5-FLUOROQUINAZOLINE
CAS No.: 16499-60-8
Chemical Name: 4-CHLORO-5-FLUOROQUINAZOLINE
Synonyms: 4-CHLORO-5-FLUOROQUINAZOLINE;Quinazoline, 4-chloro-5-fluoro-;4-chloro-5-fluoroquinazoline - [C83484]
CBNumber: CB0839327
Molecular Formula: C8H4ClFN2
Formula Weight: 182.58
MOL File: 16499-60-8.mol

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4-CHLORO-5-FLUOROQUINAZOLINE Property

Boiling point:: 284.9±20.0 °C(Predicted)
Density: 1.447±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.35±0.30(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C374560
Product name: 4-chloro-5-fluoroquinazoline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 143234
Product name: 4-Chloro-5-fluoroquinazoline
Purity: 97%
Packaging: 1g
Price: $751
Updated: 2021/12/16

AK Scientific

Product number: 8378AA
Product name: 4-Chloro-5-Fluoroquinazoline
Packaging: 5g
Price: $826
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0053887
Product name: 4-CHLORO-5-FLUOROQUINAZOLINE
Purity: 95.00%
Packaging: 1G
Price: $925.31
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0053887
Product name: 4-CHLORO-5-FLUOROQUINAZOLINE
Purity: 95.00%
Packaging: 2.5G
Price: $1363.65
Updated: 2021/12/16

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4-CHLORO-5-FLUOROQUINAZOLINE Chemical Properties,Usage,Production

Synthesis

436-72-6

16499-60-8

The general procedure for the synthesis of 4-chloro-5-fluoroquinazoline from 5-fluoroquinazolin-4(1H)-one was as follows: a DCM ( 197 mg) of HATU (197 mg), diisopropylethylamine (90 μL), acetic acid (22 μL), and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(methylamino)ethoxy]quinazolin-4-amine (150 mg) ( 20 mL) solution was stirred for 2 hours. After completion of the reaction, the reaction solution was washed with water, then with brine and finally concentrated in vacuum. The residue was purified by column chromatography using DCM-5% methanol as eluent to give the title compound as a white solid (114 mg, 69% yield).NMR spectrum (DMSO-d6) δ 1.95 (s, 3H), 3.00 (s, 3H), 3.89 (t, 2H), 4.48 (m, 2H), 5.29 (s, 2H), 7.18 ( d, 1H), 7.24 (d, 1H), 7.35 (m, 2H), 7.59 (m, 2H), 7.72 (dd, 1H), 7.85 (dt, 1H), 7.96 (d, 1H), 8.46 (s, 1H), 8.58 (m, 1H), 9.70 (bs, 1H); mass spectrum m/z 478 [M+H]+.

References

[1] Patent: WO2005/51923, 2005, A1. Location in patent: Page/Page column 158-159
[2] Patent: WO2004/93880, 2004, A1. Location in patent: Page/Page column 83
[3] Patent: WO2005/26152, 2005, A1. Location in patent: Page/Page column 118
[4] Patent: WO2006/92573, 2006, A1. Location in patent: Page/Page column 64
[5] Patent: WO2007/34144, 2007, A1. Location in patent: Page/Page column 75

4-CHLORO-5-FLUOROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-5-FLUOROQUINAZOLINE Suppliers

China 63 India 1 United States 4 Global 68

Shanghai Hanhong Scientific Co.,Ltd.

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Bide Pharmatech Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Suzhou JingTong Pharmaceutical Co., Ltd.

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16499-60-8, 4-CHLORO-5-FLUOROQUINAZOLINERelated Search:

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4-CHLORO-5-FLUOROQUINAZOLINE

Quinazoline, 4-chloro-5-fluoro-

4-chloro-5-fluoroquinazoline - [C83484]

16499-60-8