4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE

Product Name: 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE
CAS No.: 139512-70-2
Chemical Name: 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE
Synonyms: BUTTPARK 44\03-90;TIMTEC-BB SBB003959;4-chloro-5-fluoro-2-aMino-aniline;4-fluoro-5-chlorophenylenediamine;-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE;4-CHLORO-1,2-DIAMINO-5-FLUOROBENZENE;1-CHLORO-4,5-DIAMINO-2-FLUOROBENZENE;1,2-DIAMINO-4-CHLORO-5-FLUOROBENZENE;4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE;4-CHLORO-5-FLUOROBENZENE-1,2-DIAMINE
CBNumber: CB1382390
Molecular Formula: C6H6ClFN2
Formula Weight: 160.58
MOL File: 139512-70-2.mol

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4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Property

Melting point:: 110-112 °C
Boiling point:: 316.2±37.0 °C(Predicted)
Density: 1.457±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 3.16±0.10(Predicted)
Appearance: Brown to reddish brown Solid
CAS DataBase Reference: 139512-70-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-20/21/22-36-22
Safety Statements: 36/37/39-26
RIDADR: 2811
Hazard Note: Harmful/Irritant
HazardClass: IRRITANT
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2921599090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C349055
Product name: 4-Chloro-5-fluorobenzene-1,2-diamine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 004670
Product name: 1,2-Diamino-4-chloro-5-fluorobenzene
Purity: 97%
Packaging: 5g
Price: $54
Updated: 2021/12/16

Oakwood

Product number: 004628
Product name: 1,2-Diamino-4-chloro-5-fluorobenzene
Purity: 99%
Packaging: 5g
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 004670
Product name: 1,2-Diamino-4-chloro-5-fluorobenzene
Purity: 97%
Packaging: 1g
Price: $16
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3830-7-15
Product name: 1,2-Diamino-4-chloro-5-fluorobenzene
Purity: 98%
Packaging: 1g
Price: $25
Updated: 2021/12/16

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4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Chemical Properties,Usage,Production

Chemical Properties

grey to light brown powder

Biological Activity

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE has been shown to have a high frequency of human activity using a patch clamp technique on human erythrocytes and also inhibits bacterial growth by binding to DNA dependent RNA polymerase, thereby preventing transcription and replication.

Synthesis

104222-34-6

139512-70-2

The general procedure for the synthesis of 4-chloro-5-fluoro-o-phenylenediamine from 5-chloro-4-fluoro-2-nitroaniline was as follows: first, the reducing agent, hydrazine monocarbonate, was prepared by slow neutralization of 12.5 mL of hydrazine hydrate with 12.5 mL of 90% formic acid under ice-bath conditions. Subsequently, the compound 5-chloro-4-fluoro-2-nitroaniline (6 g, 0.03 mol) was dissolved in 20 mL of methanol and zinc powder (4 g, 0.06 mol) was added. The above solution was mixed with the prepared hydrazine monocarbonate solution and stirred at room temperature under nitrogen protection (Note: the reaction is exothermic and accompanied by gas production). The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was filtered and the filtrate concentrated. The residue was dissolved in dichloromethane and washed twice with saturated brine solution to remove excess of hydrazine monoformate. The organic layers were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to afford the target product 4-chloro-5-fluoro-o-phenylenediamine (89% yield, melting point 84-86 °C).

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 230 - 240

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Suppliers

Belgium 1 China 83 France 1 Germany 2 India 2 Switzerland 2 United Kingdom 10 United States 18 Global 119

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
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Energy Chemical

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Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
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Nanjing Chemlin Chemical Co., Ltd

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Email: info@chemlin.com.cn
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Shanghai Hanhong Scientific Co.,Ltd.

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Shandong Xiya Chemical Co., Ltd

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Hunan Hui Bai Shi Biotechnology Co., Ltd.

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Clearsynth Labs Limited

Tel: +91-22-26355700
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Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.

Tel: 0515-89701588 13770166955
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ProdList: 620
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View Lastest Price from 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE manufacturers

Career Henan Chemical Co

Product: -CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 139512-70-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 100kg
Release date: 2020-02-01

139512-70-2, 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINERelated Search:

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 4-Chloro-5-iodo-6-methylpyrimidin-2-amine 4-Chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-5-iodopyrimidine 4-Chloro-5-Bromopyrimidine Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) 4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 4-Chloro-5-azaindole-3-carbaldehyde 4-Chloro-5-methylpyrimidine 4-CHLORO-5-IODO-2-METHYL-PYRIMIDINE 4-CHLORO-5-FLUOROQUINAZOLINE 2,4-Dichloro-6-methoxyquinazoline o-Phenylenediamine

TIMTEC-BB SBB003959

1,2-DIAMINO-4-CHLORO-5-FLUOROBENZENE

1-CHLORO-4,5-DIAMINO-2-FLUOROBENZENE

4-CHLORO-1,2-DIAMINO-5-FLUOROBENZENE

4-CHLORO-5-FLUORO-1,2-PHENYLENEDIAMINE

4-CHLORO-5-FLUOROBENZENE-1,2-DIAMINE

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE

BUTTPARK 44\03-90

4-Chloro-1,2-diamino-5-fluorobenzene~1,2-Diamino-4-chloro-5-fluorobenzene

4-Chloro-1,2-diamino-5-fluorobenzene 98%

4-Chloro-1,2-diamino-5-fluorobenzene98%

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 99%

4-Chloro-5-fluoro-o-phenylenediamine,99%

4-Chloro-5-fluorobenzene-1,2-diamine 98%

4-Chloro-5-fluorophenylene-1,2-diamine, 5-Chloro-4-fluorophenylene-1,2-diamine, 1-Chloro-4,5-diamino-2-fluorobenzene

4-chloro-5-fluoro-2-aMino-aniline

1,2-BenzenediaMine, 4-chloro-5-fluoro-

1,2-DiaMino-4-chloro-5-fluorobenzene[4,5-diaMino-2-chlorofluorobenzene]

-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE

4-Chloro-5-fluoro-1,2-benzenediamine

4-fluoro-5-chlorophenylenediamine

139512-70-2

Fluorine series