Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
Uses- Product Name
- Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
- CAS No.
- 695-85-2
- Chemical Name
- Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
- Synonyms
- 4-Chloro-5-methoxypyrimidine;Pyrimidine, 4-chloro-5-methoxy-;Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI);Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) ISO 9001：2015 REACH
- CBNumber
- CB71045162
- Molecular Formula
- C5H5ClN2O
- Formula Weight
- 144.56
- MOL File
- 695-85-2.mol
Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) Property
- Melting point:
- 63-64℃
- Boiling point:
- 221.9±20.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.17±0.16(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C5H5ClN2O/c1-9-4-2-7-3-8-5(4)6/h2-3H,1H3
- InChIKey
- CTMIYYREUVYVEL-UHFFFAOYSA-N
- SMILES
- C1=NC=C(OC)C(Cl)=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C373573
- Product name
- 4-chloro-5-methoxypyrimidine
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR929762
- Product name
- 4-Chloro-5-methoxypyrimidine
- Purity
- 95%
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR929762
- Product name
- 4-Chloro-5-methoxypyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- 089772
- Product name
- 4-Chloro-5-methoxypyrimidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $341
- Updated
- 2021/12/16
- Product number
- HCH0358908
- Product name
- 4-CHLORO-5-METHOXYPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.67
- Updated
- 2021/12/16
Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) Chemical Properties,Usage,Production
Uses
4-Chloro-5-methoxypyrimidine is a heterocyclic compound that can be used as an intermediate in organic synthesis.
Synthesis
695-87-4
695-85-2
The general procedure for the synthesis of 4-chloro-5-methoxypyrimidine from 4-hydroxy-5-methoxypyrimidine was as follows: 5-methoxypyrimidin-4-ol (57 g, 0.452 mol) was suspended in phosphorous triclosan (540 mL) and heated to reflux for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent dichloromethane/methanol = 10:1), and after confirming the completion of the reaction, most of the phosphorous trichloride was evaporated under reduced pressure. The residue was slowly poured into ice water (2 L) and the pH was adjusted with potassium carbonate (250 g) to about 7. Subsequently, the mixture was extracted with ethyl acetate/tert-butyl methyl ether (3:1, 4 x 250 mL). The organic phases were combined, washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4-chloro-5-methoxypyrimidine (3S g, 58% yield) as a yellow solid. Its 1H NMR (400 MHz, DMSO-d6) data were as follows: δ 8.63 (s, 1H), 8.32 (s, 1H), 4.02 (s, 3H).
References
[1] Journal of Organic Chemistry, 1997, vol. 62, # 26, p. 9192 - 9202
[2] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 80
[3] Organic Process Research and Development, 2015, vol. 19, # 6, p. 639 - 645
Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) manufacturers
- Product
- Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) 695-85-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13
- Product
- Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) 695-85-2
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10