4-Chloro-5-iodopyrimidine
- Product Name
- 4-Chloro-5-iodopyrimidine
- CAS No.
- 63558-65-6
- Chemical Name
- 4-Chloro-5-iodopyrimidine
- Synonyms
- 4-Chloro-5-iodopyrimidine;5-Iodo-4-Chloropyrimidine;Pyrimidine, 4-chloro-5-iodo-;4-Chloro-5-iodopyriMidine, 95+%;4-Chloro-5-iodo-pyriMidine 97%;4-HYDROXYBENZENSULFONIC ACID SODIUM;4-Chloro-5-iodopyrimidine ISO 9001：2015 REACH
- CBNumber
- CB8875529
- Molecular Formula
- C4H2ClIN2
- Formula Weight
- 240.43
- MOL File
- 63558-65-6.mol
4-Chloro-5-iodopyrimidine Property
- Melting point:
- 63-65 °C
- Boiling point:
- 275.0±20.0 °C(Predicted)
- Density
- 2.187±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- -1.35±0.16(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381318
- Product name
- 4-Chloro-5-iodopyrimidine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC12052
- Product name
- 4-Chloro-5-iodopyrimidine
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 072265
- Product name
- 4-Chloro-5-iodopyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- FC12052
- Product name
- 4-Chloro-5-iodopyrimidine
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 3H32-M-09
- Product name
- 4-Chloro-5-iodopyrimidine
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
4-Chloro-5-iodopyrimidine Chemical Properties,Usage,Production
Synthesis
4349-07-9
63558-65-6
The general procedure for the synthesis of 4-chloro-5-iodopyrimidine from 4-hydroxy-5-iodopyrimidine was as follows: 12.7 mL (144.6 mmol) of oxalyl chloride was added slowly and dropwise to a stirred solution containing 7.7 mL (99 mmol) of N,N-dimethylformamide (DMF) and 150 mL of ethylene dichloride at 0°C to control the escape of drastic gas. After the gas release stopped, 10.0 g of 4-hydroxy-5-iodopyrimidine was added and the reaction mixture was heated to reflux for 3 hours. After completion of the reaction, it was cooled to room temperature and the reaction solution was partitioned between water and dichloromethane. The organic layer was separated, dried over anhydrous magnesium sulfate (MgSO?) and concentrated under reduced pressure to remove the solvent to give 9.6 g (88% yield) of the target product 4-chloro-5-iodopyrimidine. The product was confirmed by 1H-NMR (300 MHz, CDCl?): δ 8.89 (s, 1H) and 8.98 (s, 1H); electrospray ionization mass spectrometry (ESIMS) showed [M + H]+ m/z 241.1.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 9, p. 2419 - 2422
[2] Patent: WO2005/16914, 2005, A1. Location in patent: Page/Page column 44
[3] Patent: WO2014/60432, 2014, A1. Location in patent: Page/Page column 139; 140
[4] Chemical & Pharmaceutical Bulletin, 1986, vol. 34, # 7, p. 2719 - 2724
[5] Patent: US2002/52375, 2002, A1
4-Chloro-5-iodopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-5-iodopyrimidine manufacturers
- Product
- 4-Chloro-5-iodopyrimidine 63558-65-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- 4-Chloro-5-iodopyrimidine 63558-65-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 4-Chloro-5-iodopyrimidine 63558-65-6
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04