ChemicalBook > CAS DataBase List > 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE

Product Name
4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE
CAS No.
139512-70-2
Chemical Name
4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE
Synonyms
BUTTPARK 44\03-90;TIMTEC-BB SBB003959;4-chloro-5-fluoro-2-aMino-aniline;4-fluoro-5-chlorophenylenediamine;-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE;4-CHLORO-1,2-DIAMINO-5-FLUOROBENZENE;1-CHLORO-4,5-DIAMINO-2-FLUOROBENZENE;1,2-DIAMINO-4-CHLORO-5-FLUOROBENZENE;4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE;4-CHLORO-5-FLUOROBENZENE-1,2-DIAMINE
CBNumber
CB1382390
Molecular Formula
C6H6ClFN2
Formula Weight
160.58
MOL File
139512-70-2.mol
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4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Property

Melting point:
110-112 °C
Boiling point:
316.2±37.0 °C(Predicted)
Density 
1.457±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
3.16±0.10(Predicted)
Appearance
Brown to reddish brown Solid
CAS DataBase Reference
139512-70-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-20/21/22-36-22
Safety Statements 
36/37/39-26
RIDADR 
2811
Hazard Note 
Harmful/Irritant
HazardClass 
IRRITANT
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2921599090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
C349055
Product name
4-Chloro-5-fluorobenzene-1,2-diamine
Packaging
250mg
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
004670
Product name
1,2-Diamino-4-chloro-5-fluorobenzene
Purity
97%
Packaging
1g
Price
$16
Updated
2021/12/16
SynQuest Laboratories
Product number
3830-7-15
Product name
1,2-Diamino-4-chloro-5-fluorobenzene
Purity
98%
Packaging
1g
Price
$25
Updated
2021/12/16
Matrix Scientific
Product number
004670
Product name
1,2-Diamino-4-chloro-5-fluorobenzene
Purity
97%
Packaging
5g
Price
$54
Updated
2021/12/16
Oakwood
Product number
004628
Product name
1,2-Diamino-4-chloro-5-fluorobenzene
Purity
99%
Packaging
5g
Price
$55
Updated
2021/12/16
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4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Chemical Properties,Usage,Production

Chemical Properties

grey to light brown powder

Biological Activity

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE has been shown to have a high frequency of human activity using a patch clamp technique on human erythrocytes and also inhibits bacterial growth by binding to DNA dependent RNA polymerase, thereby preventing transcription and replication.

Synthesis

104222-34-6

139512-70-2

The general procedure for the synthesis of 4-chloro-5-fluoro-o-phenylenediamine from 5-chloro-4-fluoro-2-nitroaniline was as follows: first, the reducing agent, hydrazine monocarbonate, was prepared by slow neutralization of 12.5 mL of hydrazine hydrate with 12.5 mL of 90% formic acid under ice-bath conditions. Subsequently, the compound 5-chloro-4-fluoro-2-nitroaniline (6 g, 0.03 mol) was dissolved in 20 mL of methanol and zinc powder (4 g, 0.06 mol) was added. The above solution was mixed with the prepared hydrazine monocarbonate solution and stirred at room temperature under nitrogen protection (Note: the reaction is exothermic and accompanied by gas production). The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was filtered and the filtrate concentrated. The residue was dissolved in dichloromethane and washed twice with saturated brine solution to remove excess of hydrazine monoformate. The organic layers were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to afford the target product 4-chloro-5-fluoro-o-phenylenediamine (89% yield, melting point 84-86 °C).

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 230 - 240

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Suppliers

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View Lastest Price from 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE manufacturers

Career Henan Chemical Co
Product
-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 139512-70-2
Price
US $1.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
100kg
Release date
2020-02-01

139512-70-2, 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINERelated Search:

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 4-Chloro-5-iodo-6-methylpyrimidin-2-amine 4-Chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-5-iodopyrimidine 4-Chloro-5-Bromopyrimidine Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) 4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 4-Chloro-5-azaindole-3-carbaldehyde 4-Chloro-5-methylpyrimidine 4-CHLORO-5-IODO-2-METHYL-PYRIMIDINE 4-CHLORO-5-FLUOROQUINAZOLINE 2,4-Dichloro-6-methoxyquinazoline o-Phenylenediamine

  • TIMTEC-BB SBB003959
  • 1,2-DIAMINO-4-CHLORO-5-FLUOROBENZENE
  • 1-CHLORO-4,5-DIAMINO-2-FLUOROBENZENE
  • 4-CHLORO-1,2-DIAMINO-5-FLUOROBENZENE
  • 4-CHLORO-5-FLUORO-1,2-PHENYLENEDIAMINE
  • 4-CHLORO-5-FLUOROBENZENE-1,2-DIAMINE
  • 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE
  • BUTTPARK 44\03-90
  • 4-Chloro-1,2-diamino-5-fluorobenzene~1,2-Diamino-4-chloro-5-fluorobenzene
  • 4-Chloro-1,2-diamino-5-fluorobenzene 98%
  • 4-Chloro-1,2-diamino-5-fluorobenzene98%
  • 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 99%
  • 4-Chloro-5-fluoro-o-phenylenediamine,99%
  • 4-Chloro-5-fluorobenzene-1,2-diamine 98%
  • 4-Chloro-5-fluorophenylene-1,2-diamine, 5-Chloro-4-fluorophenylene-1,2-diamine, 1-Chloro-4,5-diamino-2-fluorobenzene
  • 4-chloro-5-fluoro-2-aMino-aniline
  • 1,2-BenzenediaMine, 4-chloro-5-fluoro-
  • 1,2-DiaMino-4-chloro-5-fluorobenzene[4,5-diaMino-2-chlorofluorobenzene]
  • -CHLORO-5-FLUORO-O-PHENYLENEDIAMINE
  • 4-Chloro-5-fluoro-1,2-benzenediamine
  • 4-fluoro-5-chlorophenylenediamine
  • 139512-70-2
  • Fluorine series