2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine

Product Name: 2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine
CAS No.: 543712-81-8
Chemical Name: 2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine
Synonyms: 102239;oro-N-(5-methyL;2,5-dichloro-N-(5-Methyl-1H-pyrazol-3-yl)pyriMidin-4-aMine;2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine;4-Pyrimidinamine, 2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)-
CBNumber: CB32470806
Molecular Formula: C8H7Cl2N5
Formula Weight: 244.08
MOL File: 543712-81-8.mol

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2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: D438650
Product name: 2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D438650
Product name: 2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine
Packaging: 50mg
Price: $90
Updated: 2021/12/16

TRC

Product number: D438650
Product name: 2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine
Packaging: 100mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD38499
Product name: 2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine
Packaging: 50mg
Price: $74.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD38499
Product name: 2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine
Packaging: 100mg
Price: $119
Updated: 2021/12/16

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2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine Chemical Properties,Usage,Production

Synthesis

31230-17-8

5750-76-5

543712-81-8

The general procedure for the synthesis of 2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-aminopyrimidine from 3-amino-5-methyl-1H-pyrazole and 2,4,5-trichloropyrimidine was as follows: to a solution of 5-methyl-1H-pyrazol-3-amine (4.00 g, 41.2 mmol) in anhydrous ethanol (100 mL) was added triethylamine (12.51 g (123.6 mmol) and 2,4,5-trichloropyrimidine (7.56 g, 41.2 mmol). The reaction mixture was stirred at room temperature for 16 h and subsequently concentrated under vacuum. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate, v/v = 1/1) to afford the target compound 2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-aminopyrimidine as a light yellow solid (9.00 g, 89.5% yield). Mass spectrum (ESI, positive ion mode) m/z: 244.1 [M + H]+; NMR hydrogen spectrum (600 MHz, DMSO-d6) δ (ppm): 12.32 (broad single peak, 1H), 9.70 (single peak, 1H), 8.33 (single peak, 1H), 6.28 (single peak, 1H), 2.25 (single peak, 3H).

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 1, p. 262 - 276
[2] Organic Process Research and Development, 2013, vol. 17, # 9, p. 1123 - 1130
[3] Patent: WO2015/94803, 2015, A1. Location in patent: Paragraph 323
[4] Patent: CN104672250, 2017, B. Location in patent: Paragraph 0762; 0763; 0764; 0765
[5] Patent: EP2754659, 2014, A1. Location in patent: Paragraph 0061-0063

2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine Suppliers

China 25 India 1 United Kingdom 1 United States 4 Global 31

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543712-81-8, 2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamineRelated Search:

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543712-81-8