2,4-DIFLUOROPYRIMIDINE

Synthesis

Product Name: 2,4-DIFLUOROPYRIMIDINE
CAS No.: 2802-61-1
Chemical Name: 2,4-DIFLUOROPYRIMIDINE
Synonyms: EOS-61621;NSC 331813;2,4-DIFLUOROPYRIMIDINE;2,4-DIFLUOROPYRIMMIDINE;Pyrimidine, 2,4-difluoro-;2,4-Difluoropyrimidine98%;2,4-Difluoropyrimidine 98%;Pyrimidine, 2,4-difluoro- (6CI,8CI,9CI);2,4-DIFLUOROPYRIMIDINE ISO 9001：2015 REACH
CBNumber: CB7263268
Molecular Formula: C4H2F2N2
Formula Weight: 116.07
MOL File: 2802-61-1.mol

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2,4-DIFLUOROPYRIMIDINE Property

Boiling point:: 118-120 °C
Density: 1.359 g/mL at 25 °C
refractive index: n20/D 1.432
Flash point:: 106 °F
pka: -2.52±0.20(Predicted)
form: liquid
color: Clear, colourless
CAS DataBase Reference: 2802-61-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 10-22-37/38-41
Safety Statements: 26-39
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 661082
Product name: 2,4-Difluoropyrimidine
Purity: 97%
Packaging: 500mg
Price: $161
Updated: 2023/06/20

Sigma-Aldrich

Product number: 661082
Product name: 2,4-Difluoropyrimidine
Purity: 97%
Packaging: 100mg
Price: $53.6
Updated: 2023/01/07

TRC

Product number: D448643
Product name: 2,4-Difluoropyrimidine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC1056
Product name: 2,4-Difluoropyrimidine
Purity: 98%
Packaging: 1g
Price: $67
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-3-X9
Product name: 2,4-Difluoropyrimidine
Purity: 98%
Packaging: 1g
Price: $108
Updated: 2021/12/16

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2,4-DIFLUOROPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

Crown ethers are able to enhance the performance of KF in two ways. Firstly, they complex the potassium cation making a better fluoride source and secondly they increase the solubility of KF in the solvent. KF with a catalytic amount of dicyclohexano-18-crown-6 in tetraglyme converted 2,4-dichloropyrimidine into 2,4-difluoropyrimidine.

Uses

2,4-Difluoropyrimidine can be used as a starting material to synthesize:

3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH₁) inhibitors.
N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 22, p. 149, 1985 DOI: 10.1002/jhet.5570220137

2,4-DIFLUOROPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DIFLUOROPYRIMIDINE Suppliers

China 57 Europe 1 Germany 2 Switzerland 1 The Netherlands 1 United Kingdom 6 United States 13 Global 81

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Wuhan Chemwish Technology Co., Ltd

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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Jinan Trio PharmaTech Co., Ltd.

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Shanghai Yolne Chemical Co., Ltd.

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Bide Pharmatech Ltd.

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Shanghai Jovan Biochemical Technology Co. Ltd.

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View Lastest Price from 2,4-DIFLUOROPYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4-DIFLUOROPYRIMIDINE 2802-61-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Dideu Industries Group Limited

Product: 2,4-DIFLUOROPYRIMIDINE 2802-61-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-03

Career Henan Chemical Co

Product: 2,4-DIFLUOROPYRIMIDINE 2802-61-1
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

2802-61-1, 2,4-DIFLUOROPYRIMIDINERelated Search:

5-chloro-2,4-difluoropyrimidine 2-ETHOXY-4,6-DIFLUOROPYRIMIDINE 2-MORPHOLINO-4,6-DIFLUOROPYRIMIDINE,98% 2,5-Difluoropyridine 3,5-Difluoropyridine 3,5-Difluoropyridine-2,6-diamine 5-BROMO-2,4-DIFLUOROPYRIMIDINE 4-AMINO-2,6-DIFLUOROPYRIMIDINE 5-Chloro-2,4,6-trifluoropyrimidine 2,4,6-TRIFLUOROPYRIMIDINE 2,4-DIFLUOROPYRIMIDINE 5-Chloro-2,3-difluoropyridine 2-AMINO-4,6-DIFLUOROPYRIMIDINE 4-Amino-3,5-dichloro-2,6-difluoropyridine 2,3-Difluoropyridine 2,6-Difluoropyridine-3-boronic acid 3,5-DICHLORO-2,6-DIFLUOROPYRIDINE 4-Pyrimidinamine,2,6-difluoro-N-methyl-

2,4-DIFLUOROPYRIMIDINE

NSC 331813

EOS-61621

Pyrimidine, 2,4-difluoro- (6CI,8CI,9CI)

2,4-Difluoropyrimidine 98%

2,4-Difluoropyrimidine98%

Pyrimidine, 2,4-difluoro-

2,4-DIFLUOROPYRIMIDINE ISO 9001：2015 REACH

2,4-DIFLUOROPYRIMMIDINE

2802-61-1

Pyrimidines

Heterocyclic Building Blocks

Building Blocks

PYRIMIDINE

Halides

Pyrazines, Pyrimidines & Pyridazines

Heterocyclic Compounds

Pyrazines, Pyrimidines & Pyridazines

Building Blocks

Heterocyclic Building Blocks

Pyrimidines