Synthesis
ChemicalBook > CAS DataBase List > 2,4-DIFLUOROPYRIMIDINE

2,4-DIFLUOROPYRIMIDINE

Synthesis
Product Name
2,4-DIFLUOROPYRIMIDINE
CAS No.
2802-61-1
Chemical Name
2,4-DIFLUOROPYRIMIDINE
Synonyms
EOS-61621;NSC 331813;2,4-DIFLUOROPYRIMIDINE;2,4-DIFLUOROPYRIMMIDINE;Pyrimidine, 2,4-difluoro-;2,4-Difluoropyrimidine98%;2,4-Difluoropyrimidine 98%;2,4-Difluoropyrimidine;Pyrimidine, 2,4-difluoro- (6CI,8CI,9CI);2,4-DIFLUOROPYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB7263268
Molecular Formula
C4H2F2N2
Formula Weight
116.07
MOL File
2802-61-1.mol
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2,4-DIFLUOROPYRIMIDINE Property

Boiling point:
118-120 °C
Density 
1.359 g/mL at 25 °C
refractive index 
n20/D 1.432
Flash point:
106 °F
pka
-2.52±0.20(Predicted)
form 
liquid
color 
Clear, colourless
CAS DataBase Reference
2802-61-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
10-22-37/38-41
Safety Statements 
26-39
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
3
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
661082
Product name
2,4-Difluoropyrimidine
Purity
97%
Packaging
500mg
Price
$161
Updated
2023/06/20
Sigma-Aldrich
Product number
661082
Product name
2,4-Difluoropyrimidine
Purity
97%
Packaging
100mg
Price
$53.6
Updated
2023/01/07
TRC
Product number
D448643
Product name
2,4-Difluoropyrimidine
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
018269
Product name
2,4-Difluoropyrimidine
Purity
95%
Packaging
1g
Price
$52
Updated
2021/12/16
Apolloscientific
Product number
PC1056
Product name
2,4-Difluoropyrimidine
Purity
98%
Packaging
1g
Price
$67
Updated
2021/12/16
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2,4-DIFLUOROPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

Crown ethers are able to enhance the performance of KF in two ways. Firstly, they complex the potassium cation making a better fluoride source and secondly they increase the solubility of KF in the solvent. KF with a catalytic amount of dicyclohexano-18-crown-6 in tetraglyme converted 2,4-dichloropyrimidine into 2,4-difluoropyrimidine.

Uses

2,4-Difluoropyrimidine can be used as a starting material to synthesize:

  • 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH1) inhibitors.
  • N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 22, p. 149, 1985 DOI: 10.1002/jhet.5570220137

2,4-DIFLUOROPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-DIFLUOROPYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,4-DIFLUOROPYRIMIDINE 2802-61-1
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Career Henan Chemical Co
Product
2,4-DIFLUOROPYRIMIDINE 2802-61-1
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

2802-61-1, 2,4-DIFLUOROPYRIMIDINERelated Search:

5-chloro-2,4-difluoropyrimidine 2-ETHOXY-4,6-DIFLUOROPYRIMIDINE 2-MORPHOLINO-4,6-DIFLUOROPYRIMIDINE,98% 2,5-Difluoropyridine 3,5-Difluoropyridine 3,5-Difluoropyridine-2,6-diamine 5-BROMO-2,4-DIFLUOROPYRIMIDINE 4-AMINO-2,6-DIFLUOROPYRIMIDINE 5-Chloro-2,4,6-trifluoropyrimidine 2,4,6-TRIFLUOROPYRIMIDINE 2,4-DIFLUOROPYRIMIDINE 5-Chloro-2,3-difluoropyridine 2-AMINO-4,6-DIFLUOROPYRIMIDINE 4-Amino-3,5-dichloro-2,6-difluoropyridine 2,3-Difluoropyridine 2,6-Difluoropyridine-3-boronic acid 3,5-DICHLORO-2,6-DIFLUOROPYRIDINE 4-Pyrimidinamine,2,6-difluoro-N-methyl-

  • 2,4-DIFLUOROPYRIMIDINE
  • NSC 331813
  • EOS-61621
  • Pyrimidine, 2,4-difluoro- (6CI,8CI,9CI)
  • 2,4-Difluoropyrimidine 98%
  • 2,4-Difluoropyrimidine98%
  • Pyrimidine, 2,4-difluoro-
  • 2,4-DIFLUOROPYRIMIDINE ISO 9001：2015 REACH
  • 2,4-DIFLUOROPYRIMMIDINE
  • 2,4-<WBR>Difluoropyrimidine
  • 2802-61-1
  • Pyrimidines
  • Heterocyclic Building Blocks
  • Building Blocks
  • PYRIMIDINE
  • Halides
  • Pyrazines, Pyrimidines & Pyridazines
  • Heterocyclic Compounds
  • Pyrazines, Pyrimidines & Pyridazines
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines