3,5-Dibromo-2-chloropyrazine

Product Name: 3,5-Dibromo-2-chloropyrazine
CAS No.: 1082843-70-6
Chemical Name: 3,5-Dibromo-2-chloropyrazine
Synonyms: 2-Chloro-3,5-dibroMopyrazine;3,5-Dibromo-2-chloropyrazine;2-chlorine-3,5-dibromopyrazine;Pyrazine, 3,5-dibromo-2-chloro-;3,5-Dibromo-2-chloropyrazine ISO 9001：2015 REACH
CBNumber: CB32471575
Molecular Formula: C4HBr2ClN2
Formula Weight: 272.33
MOL File: 1082843-70-6.mol

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3,5-Dibromo-2-chloropyrazine Property

Boiling point:: 261℃
Density: 2.265
Flash point:: 112℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -6.65±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D425230
Product name: 3,5-Dibromo-2-chloropyrazine
Packaging: 250mg
Price: $1230
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0104175
Product name: 3,5-DIBROMO-2-CHLOROPYRAZINE
Purity: 95.00%
Packaging: 250MG
Price: $1871.1
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0104175
Product name: 3,5-DIBROMO-2-CHLOROPYRAZINE
Purity: 95.00%
Packaging: 25MG
Price: $739.2
Updated: 2021/12/16

Apolloscientific

Product number: OR926025
Product name: 3,5-Dibromo-2-chloropyrazine
Purity: >98%
Packaging: 10g
Price: $756
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-D-4W
Product name: 3,5-Dibromo-2-chloropyrazine
Purity: 98.0%
Packaging: 10g
Price: $1210
Updated: 2021/12/16

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3,5-Dibromo-2-chloropyrazine Chemical Properties,Usage,Production

Uses

An intermediate used for the 1) preparation of a number of salts of fused pyrazine derivative for treatment of degenerative and inflammatory diseases, 2) preparation of a number of pyridine and pyrazine derivatives as protein kinase modulators for the treatment of CDK9-mediated diseases.

Uses

3,5-Dibromo-2-chloropyrazine is an intermediate used for the 1) preparation of a number of salts of fused pyrazine derivative for treatment of degenerative and inflammatory diseases, 2) preparation of a number of pyridine and pyrazi ne derivatives as protein kinase modulators for the treatment of CDK9-mediated diseases.

Synthesis

24241-18-7

1082843-70-6

General procedure for the synthesis of 3,5-dibromo-2-chloropyrazine from 2-amino-3,5-dibromopyrazine: titanium(IV) chloride (174 g, 926 mmol) was added to a solution of 2-amino-3,5-dibromopyrazine (234 g, 932 mmol) in dichloromethane (DCM, 700 mL), followed by slow addition of tert-butyl nitrite (572 g, 5.55 mol). The reaction mixture was stirred at room temperature for 2 h and then the reaction was quenched with water (500 mL). The reaction mixture was extracted with dichloromethane (3 × 500 mL). The organic layers were combined and concentrated under reduced pressure. Purification of the residue by rapid column chromatography on silica gel (eluent: ethyl acetate/petroleum ether, 1:50 v/v) afforded 3,5-dibromo-2-chloropyrazine (90d) as a colorless oil (210 g, 83% yield). Mass spectrum (LCMS, ESI positive ion mode): calculated value C4HBr2ClN2 [M+H]+: 272.8, measured value: 272.6.

References

[1] Patent: US2014/364414, 2014, A1. Location in patent: Paragraph 0945; 0952-0953
[2] Patent: US2009/286798, 2009, A1. Location in patent: Page/Page column 26-27
[3] Patent: US2011/118269, 2011, A1. Location in patent: Page/Page column 14
[4] Patent: WO2014/1377, 2014, A1. Location in patent: Page/Page column 153; 154

3,5-Dibromo-2-chloropyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Dibromo-2-chloropyrazine Suppliers

Canada 1 China 78 Germany 1 India 2 United States 8 Global 90

Shanghai YuYuan Pharmaceutical Co., Ltd.

Tel: 13052276172
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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PharmaBlock Sciences (Nanjing),Inc.

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Pure Chemistry Scientific Inc.

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Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
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ZEROSCHEM.CO.,LTD.

Tel: 10-61256048 13810278579
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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Country: China
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Chemsky（shanghai）International Co.,Ltd.

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Tongchuang Pharma(Suzhou). Co., Ltd.

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ProdList: 993
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View Lastest Price from 3,5-Dibromo-2-chloropyrazine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3,5-Dibromo-2-chloropyrazine 1082843-70-6
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-29

Career Henan Chemical Co

Product: 3,5-Dibromo-2-chloropyrazine 1082843-70-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-20

1082843-70-6, 3,5-Dibromo-2-chloropyrazineRelated Search:

3,5-Dibromo-2-chloropyrazine

2-Chloro-3,5-dibroMopyrazine

Pyrazine, 3,5-dibromo-2-chloro-

3,5-Dibromo-2-chloropyrazine ISO 9001：2015 REACH

2-chlorine-3,5-dibromopyrazine

1082843-70-6

C4HBr2ClN2

Aromatics

Heterocycles

Intermediates