3,5-Dibromo-2-chloropyrazine
- Product Name
- 3,5-Dibromo-2-chloropyrazine
- CAS No.
- 1082843-70-6
- Chemical Name
- 3,5-Dibromo-2-chloropyrazine
- Synonyms
- 2-Chloro-3,5-dibroMopyrazine;3,5-Dibromo-2-chloropyrazine;2-chlorine-3,5-dibromopyrazine;Pyrazine, 3,5-dibromo-2-chloro-;3,5-Dibromo-2-chloropyrazine ISO 9001：2015 REACH
- CBNumber
- CB32471575
- Molecular Formula
- C4HBr2ClN2
- Formula Weight
- 272.33
- MOL File
- 1082843-70-6.mol
3,5-Dibromo-2-chloropyrazine Property
- Boiling point:
- 261℃
- Density
- 2.265
- Flash point:
- 112℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -6.65±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D425230
- Product name
- 3,5-Dibromo-2-chloropyrazine
- Packaging
- 250mg
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- HCH0104175
- Product name
- 3,5-DIBROMO-2-CHLOROPYRAZINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1871.1
- Updated
- 2021/12/16
- Product number
- HCH0104175
- Product name
- 3,5-DIBROMO-2-CHLOROPYRAZINE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- OR926025
- Product name
- 3,5-Dibromo-2-chloropyrazine
- Purity
- >98%
- Packaging
- 10g
- Price
- $756
- Updated
- 2021/12/16
- Product number
- 3H32-D-4W
- Product name
- 3,5-Dibromo-2-chloropyrazine
- Purity
- 98.0%
- Packaging
- 10g
- Price
- $1210
- Updated
- 2021/12/16
3,5-Dibromo-2-chloropyrazine Chemical Properties,Usage,Production
Uses
An intermediate used for the 1) preparation of a number of salts of fused pyrazine derivative for treatment of degenerative and inflammatory diseases, 2) preparation of a number of pyridine and pyrazine derivatives as protein kinase modulators for the treatment of CDK9-mediated diseases.
Uses
3,5-Dibromo-2-chloropyrazine is an intermediate used for the 1) preparation of a number of salts of fused pyrazine derivative for treatment of degenerative and inflammatory diseases, 2) preparation of a number of pyridine and pyrazi ne derivatives as protein kinase modulators for the treatment of CDK9-mediated diseases.
Synthesis
24241-18-7
1082843-70-6
General procedure for the synthesis of 3,5-dibromo-2-chloropyrazine from 2-amino-3,5-dibromopyrazine: titanium(IV) chloride (174 g, 926 mmol) was added to a solution of 2-amino-3,5-dibromopyrazine (234 g, 932 mmol) in dichloromethane (DCM, 700 mL), followed by slow addition of tert-butyl nitrite (572 g, 5.55 mol). The reaction mixture was stirred at room temperature for 2 h and then the reaction was quenched with water (500 mL). The reaction mixture was extracted with dichloromethane (3 × 500 mL). The organic layers were combined and concentrated under reduced pressure. Purification of the residue by rapid column chromatography on silica gel (eluent: ethyl acetate/petroleum ether, 1:50 v/v) afforded 3,5-dibromo-2-chloropyrazine (90d) as a colorless oil (210 g, 83% yield). Mass spectrum (LCMS, ESI positive ion mode): calculated value C4HBr2ClN2 [M+H]+: 272.8, measured value: 272.6.
References
[1] Patent: US2014/364414, 2014, A1. Location in patent: Paragraph 0945; 0952-0953
[2] Patent: US2009/286798, 2009, A1. Location in patent: Page/Page column 26-27
[3] Patent: US2011/118269, 2011, A1. Location in patent: Page/Page column 14
[4] Patent: WO2014/1377, 2014, A1. Location in patent: Page/Page column 153; 154
3,5-Dibromo-2-chloropyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-Dibromo-2-chloropyrazine Suppliers
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 8485655694
- sales@alchempharmtech.com
- Country
- United States
- ProdList
- 63687
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@Alfa-Chemistry.com
- Country
- United States
- ProdList
- 6814
- Advantage
- 0
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
- Tel
- --
- Fax
- --
- info@synquestlabs.com
- Country
- United States
- ProdList
- 6871
- Advantage
- 62
- Tel
- --
- Fax
- --
- sales@frontiersci.com
- Country
- United States
- ProdList
- 6222
- Advantage
- 86
- Tel
- --
- Fax
- --
- sales@matrixscientific.com
- Country
- United States
- ProdList
- 6632
- Advantage
- 80
View Lastest Price from 3,5-Dibromo-2-chloropyrazine manufacturers
- Product
- 3,5-Dibromo-2-chloropyrazine 1082843-70-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
- Product
- 3,5-Dibromo-2-chloropyrazine 1082843-70-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-20